Serum leptin concentrations in children with mild‐to‐moderate protein‐energy malnutrition

Büyükgebiz, Benal; Öztürk, Yeşim; Yılmaz, Şebnem; Arslan, Nur

doi:10.1046/j.1442-200x.2003.01787.x

Cited by 14 publications

(18 citation statements)

References 22 publications

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“…3,4,14 Palacio et al 15 identified low levels of serum leptin in malnourished children compared with normal children, and thought that this increase was the result of the suppressed secretion of leptin because of the diminished subcutaneous adipose tissue resulting from decreased energy intake. This mechanism may also be accurate for children with classical CD before GFD, because whatever the mechanism is, outcome is the same: diminished subcutaneous adipose tissue.…”

Section: Discussionmentioning

confidence: 97%

“…1 It has been reported that serum leptin concentrations in children with protein energy malnutrition and malnourished patients with chronic disease, short bowel syndrome, and anorexia nervosa are lower than in healthy subjects. 3,4 Celiac disease (CD) is a gluten-sensitive intestinal enteropathy with multifactorial etiology. It is characterized by malabsorption of nutrients by the small intestine after the ingestion of wheat gluten or related proteins from rye, oat, and barley; characteristic villous atrophy of the small intestinal mucosa, clinical and histologic recovery after a gluten-free diet (GFD), and clinical relapse after the reintroduction of gluten.…”

mentioning

confidence: 99%

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Serum Leptin Levels in Childhood Celiac Disease

Ertekin¹,

Orbak²,

Selimoğlu³

et al. 2006

Journal of Clinical Gastroenterology

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Serum Leptin Levels in Childhood Celiac Disease

Ertekin¹,

Orbak²,

Selimoğlu³

et al. 2006

Journal of Clinical Gastroenterology

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“…Utilizing either the RIA or ELISA method of detection influenced the concentration of leptin in the non-fasted or Arslanian et al, 26 Argente et al, 25 Buyukgebiz et al, 28 Charmandari et al, 27 Coutant et al, 22 Moore et al, 23 Roemmich et al states. Specifically, the non-fasted state gave a higher mean and a wider SD (P , 0.0001).…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of leptin reference ranges in the healthy paediatric prepubertal population

et al. 2009

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Objective: The initial discovery of leptin (1994) has given rise to a substantial number of published studies. This study aimed at identifying the published data on the reference ranges of total, free and bound leptin concentration in the healthy prepubertal population. Methods: A search was conducted on original English language studies published from 1994 to 2005 in the following databases: PubMed (n ¼ 58), EMBASE (n ¼ 4), Biological Abstracts (n ¼ 2) and Science Finder Scholar (n ¼ 66). A cited reference search was completed in Science Citation Index on studies with a leptin range. A meta-analysis was completed on included studies containing a dataset and a sample size for a leptin concentration range and/or mean+standard deviation for a healthy prepubertal population. Preanalytical and analytical variations were examined. Preanalytical variables included aspects such as fasting state and gender, while analytical variation comprised the type of leptin assay methodology. Results: Twelve studies met the inclusion criteria. One study examined free leptin; 11 studies examined total concentration. No studies reported leptin reference ranges established by Clinical and Laboratory Standards Institute (CLSI) criteria, although four studies reported specific study leptin ranges. The methodology of enzyme-linked immunosorbent assay demonstrated a wider leptin range than radio immunoassay (0.56 -36.35 vs. 1.01 -12.21 ng/mL). Males had a significantly lower mean leptin concentration than females (P ¼ 0.0006); obese children had a higher concentration than non-obese (P ¼ 0.0001). Conclusion:No studies have established CLSI-based leptin reference ranges in prepubertal healthy children and there is a wide variation in the published leptin concentrations. These differences suggest that caution should be used in the interpretation and comparison between studies.

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“…Serum leptin level increases with an increased amount of total body fat store and decreases in the inadequate protein-energy stage (Havel 2000;Buyukgebiz et al 2003;Dencker et al 2006). Clinically, leptin has been utilized as a parameter in children with protein-energy malnutrition (Buyukgebiz et al 2003). It is also work in concert with other mediators in controlling body inflammatory responses or bone remodeling process (Honsawek et al 2008;Lubbeke et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Leptin, a hormone regulated by the ob gene and secreted by adipocytes, controls satiety and energy expenditure through a negative feedback mechanism at the hypothalamus (Sorensen et al 1996). Serum leptin level increases with an increased amount of total body fat store and decreases in the inadequate protein-energy stage (Havel 2000;Buyukgebiz et al 2003;Dencker et al 2006). Clinically, leptin has been utilized as a parameter in children with protein-energy malnutrition (Buyukgebiz et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Serum Leptin as a Nutritional Biomarker in Children with Cerebral Palsy

Amarase

Weerasopone

Osateerakun

et al. 2016

Tohoku J. Exp. Med.

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Adequate nutrition is crucial for children with cerebral palsy (CCP). However, conventional nutritional assessments may be inadequate for defining undernourished CCP. Leptin, an adipocyte hormone controlling energy expenditure, could be a useful marker. Objectives of this cross-sectional analytic study were to explore correlations between serum leptin level and nutritional status, anthropometric measurements, and biochemical parameters in 86 CCP (aged 9 ± 2 years). Subscapular (SST) and triceps (TST) skinfold thicknesses, weight, and calculated height were obtained. Body mass index and weight-forheight (WH) Z-scores were calculated. Complete blood count and serum levels of leptin and albumin were collected. CCP were classified as undernourished if their WHZ was < −2 according to the World Health Organization criteria. Correlations between anthropometric measurements, biochemical data, and serum leptin levels were evaluated. From 86 CCP, 11 (12%) children were undernourished, and SST, hemoglobin, and hematocrit were significantly lower. Serum leptin levels of nourished and undernourished CCP were 5.4 ± 6.2 and 2.9 ± 1.6 ng/mL (p < 0.001), while the reported value from normal children was 4.9 ng/mL. Serum leptin levels demonstrated a significant correlation with SST and TST (r = 0.83 and 0.72; p < 0.001). Serum leptin was the only marker significantly correlated with WHZ (r = 0.45, p < 0.001) while adjusting for covariates. A serum leptin level of 2.2 ng/mL was the optimal cutoff point for defining adequate nutritional status (WHZ ≥ −2). The measurement of serum leptin should be included in a care scheme of CCP especially during surgical evaluation.

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Serum leptin concentrations in children with mild‐to‐moderate protein‐energy malnutrition

Cited by 14 publications

References 22 publications

Serum Leptin Levels in Childhood Celiac Disease

Serum Leptin Levels in Childhood Celiac Disease

A meta-analysis of leptin reference ranges in the healthy paediatric prepubertal population

Serum Leptin as a Nutritional Biomarker in Children with Cerebral Palsy

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