Serum leptin, atherogenic lipids and glucose levels in patients with skin tags

Abstract

Aim:To investigate the relationship between serum leptin, atherogenic lipid and glucose levels in patients with skin tags and healthy controls.Materials and Methods:A total of 58 patients, with at least three skin tags, aged 24 to 85 years, and 31 healthy controls aged 30 to 70 years, were examined in the present study. The subjects in all the groups were selected with statistically similar Body Mass Index (BMI). Fasting concentrations of plasma glucose, serum lipids including triglyceride, total cholesterol, and high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL), HbA1c, and leptin were measured by enzyme-linked immunosorbent assay (ELISA). In addition, serum LDL level was calculated using Friedewald's formula.Results:There was no significant difference in age, sex, BMI, HbA1c, triglyceride, HDL and leptin levels between the groups. Skin tags group showed significantly higher levels of total cholesterol and LDL, when compared with the healthy controls groups (P < 0.01). In addition, regression analysis showed that leptin level was positively correlated to serum triglyceride level (r = 0.265, P = 0.044).Conclusion:Total cholesterol and LDL serum levels should be controlled in patients with skin tags. On the other hand, glucose, leptin and HbA1c serum levels may not be as important as is being considered in recent times.

Plasma levels of leptin and ghrelin and their correlation with BMI, and circulating lipids and glucose in obese Tunisian women

“…These results are consistent with those of Sanlier [11] and other authors [13][14][15][16][17][18][19][20]. The correlation was consistent with that found by Ibrahim et al [21] and Ezam et al [22].…”

Assessment of Various Biochemical Parameters and BMI in Patients with Skin Tags

“…A relationship between STs and diabetes mellitus has also been reported in a study conducted by Bahgat and Safory [23]. In a study conducted by Gorpelioglu et al, there was no difference for BMI and HbA1c levels [24].…”

“…Other studies have reported significant association of Leptin levels with STs [5,25,26]. But a recent Indian study did not find a significant association between Leptin levels and STs [24]. Association of BMI with ST was found in some studies [24,27].…”

“…But a recent Indian study did not find a significant association between Leptin levels and STs [24]. Association of BMI with ST was found in some studies [24,27]. Another study did not find any association [20].…”

Molluskum Pendulum ile Karbonhidrat Metabolizması Bozukluğu Arasındaki İlişkinin Araştırılması

“…Bu da bize molluskum pendulum lezyonlarının varlığının yanı sıra fazla sayıda olmasının da glukoz toleransında bozulma için uyarıcı olması gerektiğini göstermektedir. Molluskum pendulum lezyonları olan hastaların karbonhidrat metabolizması ile ilişkili bir diğer parametre olan serum lipit düzeyleri açısından da değerlendirildiği ve aterogenik lipit profilinde bozulma olduğu ve bu hastalarda ateroskleroz ve kardiyovasküler hastalık riskinin arttığını belirten çalışmalar mevcuttur [20][21][22] . Çalışmamızda total kolesterol, trigliserid, HDL, LDL ve VLDL düzeyleri hasta grubu ve kontrol grubunda anlamlı farklılık göstermedi ancak molluskum pendulum sayısı ile total kolesterol ve trigliserid değerleri arasında doğru orantılı bir ilişki saptandı.…”