Serum leptin and weight loss in severely obese patients undergoing biliopancreatic diversion

Adami, Gian Franco; Cordera, Renzo; Campostano, Adelia; Bressani, A; Cella, Franca; Scopinaro, Nicola

doi:10.1038/sj.ijo.0800665

Cited by 17 publications

(12 citation statements)

References 5 publications

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“…The observations presented in this report further extend information on the effect of anti‐obesity surgery on the above‐mentioned parameters. In some respects, our results are in accordance with earlier findings (20, 21, 22, 23, 24). It is interesting to note that serum glucose concentration and insulin resistance in banded vertical gastroplasty patients reached the values observed in lean patients.…”

Section: Discussionsupporting

confidence: 94%

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BMI Is the Main Determinant of the Circulating Leptin in Women after Vertical Banded Gastroplasty

Zabrocka¹,

Raczyńska²,

Goyke³

et al. 2004

Obesity Research

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ZABROCKA,LIOLA, SYLWIA RACZYNSKA, ELZBIETA GOYKE, ZBIGNIEW SLEDZINSKI, AND JULIAN SWIERCZYNSKI. BMI is the main determinant of the circulating leptin in women after vertical banded gastroplasty. Obes Res. 2004;12:505-512. Objective: To assess the main determinant of serum leptin concentration changes in morbidly obese patients treated by banded vertical gastroplasty. Research Methods and Procedures: Serum leptin and insulin concentrations, insulin resistance, BMI, body weight, and body fat mass in 18 obese women and 8 obese men treated by vertical banded gastroplasty were studied. Lean women and men subjects were used as controls. Results: Before surgery, serum leptin and insulin concentrations and insulin resistance index were significantly higher in morbidly obese patients than in control subjects. BMI, body fat mass, and serum triacylglycerol concentrations were also significantly higher in obese than in lean subjects. All of these parameters gradually decreased during 50 weeks after surgery. Univariate regression analysis displayed significant correlations between the following: serum leptin concentration and BMI (and body fat mass), serum leptin concentration and serum insulin concentration, and serum leptin concentration and insulin resistance index. Multivariate regression analysis indicated that only BMI was independently correlated with the decrease in serum leptin concentration. Discussion: Obtained data suggest the following: 1) vertical banded gastroplasty causes reduction of body weight, serum leptin and insulin concentration, insulin resistance, and serum triacylglycerol concentration; and 2) BMI is the main determinant of the circulating leptin concentration in morbidly obese women after anti-obesity surgery.

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Section: Discussionsupporting

confidence: 94%

“…Plasma leptin concentration changes have also been reported in surgically induced weight loss (after gastric bypass operation) (20, 21, 22, 23, 24). Guldstrand et al (20) have suggested that the reduction in insulin concentration is a key factor responsible for serum leptin reduction after vertical banded gastroplasty (20).…”

Section: Introductionmentioning

confidence: 78%

BMI Is the Main Determinant of the Circulating Leptin in Women after Vertical Banded Gastroplasty

Zabrocka¹,

Raczyńska²,

Goyke³

et al. 2004

Obesity Research

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“…In a group of severely obese patients also receiving a biliopancreatic diversion, a normalization of serum leptin concentrations was observed despite food consumption being similar or greater than pre-operatively 16 . In this patient, the decrease in serum leptin concentrations paralleled that of BMI.…”

Section: Discussionmentioning

confidence: 86%

Serum Leptin Concentrations in Children with Prader-Willi Syndrome and Non-Syndromal Obesity

Bueno¹,

Moreno²,

Pineda³

et al. 2000

Journal of Pediatric Endocrinology and Metabolism

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There is limited information on the underlying physiological mechanisms promoting obesity in patients with Prader-Willi syndrome (PWS). The aim of this study was to investigate whether body fat regulation in children with PWS is similar to that in children with non-syndromal obesity and non-obese children. We studied three groups: 1) 72 non-obese children and adolescents; 2) 68 children with non-syndromal obesity; and 3) 11 patients with PWS. Height and weight were measured and body mass index (BMI) and BMI SDS were calculated. Fasting serum leptin concentrations were determined. Median leptin serum concentrations were similar in PWS patients and children with non-syndromal obesity. Median leptin serum concentrations were higher in these two groups than in the non-obese group. Log leptin serum concentrations and BMI SDS showed significant correlations in the three groups of patients; correlation coefficients were 0.525, 0.285 and 0.854, respectively. In conclusion, median leptin serum concentrations are similar in PWS patients and children with non-syndromal obesity. The relationship between log serum leptin concentrations and BMI SDS was different in the three groups of patients studied.

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“…This finding is in agreement with previous results obtained in patients with obesity of extreme degree. 21 However, although in severely obese patients serum leptin concentration appears to be strongly associated with eating pattern, the weakly significant positive relationship between leptin and BF mass suggests that adipose tissue still has a Several studies have demonstrated that the tendency to disinhibition and the susceptibility to hunger, as evaluated by the EI, as well as the EDI bulimia score, are higher in BED than in non-BED patients. 22 -24 Furthermore, weight fluctuation due to reducing diet is more frequent in BED patients than in the non-BED individuals.…”

Section: Discussionmentioning

confidence: 99%

Serum leptin concentration in obese patients with binge eating disorder

Adami

Campostano²,

Cella

et al. 2002

Int J Obes

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BACKGROUND:In steady-state conditions serum leptin concentration is directly related to body fat stores, but is also affected by changes in energy balance. This cross-sectional study investigated the serum leptin concentrations of severely obese patients with binge eating disorder (BED), in whom body fat was greater than normal and, because of eating pattern, rapid and repeated changes in energy balances took place. METHODS: A group of BED obese patients was compared to a group of obese patients with a regular eating pattern with the same body weight, body composition and resting energy expenditure. Serum leptin was measured and the eating attitudes were evaluated by Eating Inventory and Eating Disorder Inventory. RESULTS: In these patients serum leptin concentrations were only weakly correlated to body mass. Furthermore, in BED obese patients serum leptin concentration was higher than in their non bingeing counterparts. CONCLUSIONS: In obese patients both body fat size and eating behavior influence serum leptin concentration, but BED patients binge eating is not triggered by a low leptin value.

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Serum leptin and weight loss in severely obese patients undergoing biliopancreatic diversion

Cited by 17 publications

References 5 publications

BMI Is the Main Determinant of the Circulating Leptin in Women after Vertical Banded Gastroplasty

BMI Is the Main Determinant of the Circulating Leptin in Women after Vertical Banded Gastroplasty

Serum Leptin Concentrations in Children with Prader-Willi Syndrome and Non-Syndromal Obesity

Serum leptin concentration in obese patients with binge eating disorder

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