Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies

Gómez-Bañuelos, Eduardo; Navarro-Hernández, Rosa Elena; Corona-Meraz, Fernanda-Isadora; Madrigal-Ruiz, Perla M.; Martín-Márquez, Beatriz Teresita; Pizano-Martínez, Óscar; Aguilar-Arreola, J; Perez-Cruz, Paul Jacob; Macias-Reyes, Hector; González-López, Laura; Gámez-Nava, Jorge I.; Salazar-Páramo, Mario; Mercado, Mónica Vázquez-Del

doi:10.1186/s13075-015-0850-8

Cited by 16 publications

(8 citation statements)

References 47 publications

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“…Most of previous studies reported only leptin levels and other leptin parameters. This study reported leptin, leptin receptor, and leptin–leptin receptor ratio as the leptin parameter; the correlation of leptin and leptin receptor in this study was similar to that in a previous report by Gómez-Bañuelos et al 23 and Popruk et al 24 ; both studies reported negative correlation of leptin and leptin receptor.…”

Section: Discussionsupporting

confidence: 91%

Association of Body Dysmorphic Disorder with Leptin Levels in Patients with Normal Weight Undergoing Liposuction: A Matched Case Study

Pruksapong

Chamnanchanunt

Thanachartwet

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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Background:Liposuction is the most common aesthetic surgical procedure performed globally. Some of the patients with normal weight who seek liposuction may suffer from body dysmorphic disorder (BDD). Leptin, which is mainly produced by adipose tissue, may be associated with this condition. The aim of this study was to determine the prevalence of BDD and leptin levels in patients with normal weight seeking liposuction.Methods:Thirty-two nonobese women who sought liposuction were matched with 32 healthy volunteers by age and body mass index. Blood biochemistry, leptin levels, and BDD-Yale–Brown Obsessive-Compulsive Scale (BDD-YBOCS) questionnaires were evaluated and compared between the groups.Results:Patients who underwent liposuction had significantly higher median (interquartile range) of total BDD-YBOCS scores than healthy volunteers [25 (22–27) versus 12 (8–20); P < 0.001]. Overall, 28 (87.5%) patients had total BDD-YBOCS scores of >20, whereas 10 (31.5%) volunteers had scores of >20. Patients with total BDD-YBOCS scores of >20 had significantly lower levels of serum leptin [12.43 (7.15–16.98) ng/ml versus 15.57 (9.59–22.28) ng/ml; P = 0.043].Conclusions:Patients who underwent liposuction had a significantly higher total score of BDD-YBOCS than healthy volunteers matched by sex, age, and body mass index. Subjects with higher BDD-YBOCS scores had significantly lower serum leptin levels.

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Section: Discussionsupporting

confidence: 91%

Association of Body Dysmorphic Disorder with Leptin Levels in Patients with Normal Weight Undergoing Liposuction: A Matched Case Study

Pruksapong

Chamnanchanunt

Thanachartwet

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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“…Similar studies have also been conducted among various autoimmune diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA) . A recent study showed that serum leptin level and serum leptin/leptin receptor ratio imbalance were positively correlated with anticyclic citrullinated peptide antibodies in RA and might act as a predictor for disease activity . Therefore, LEP and LEPR gene polymorphisms might affect its expression and activity, and thereby involved in SLE pathogenesis.…”

Section: Discussionmentioning

confidence: 66%

Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population

Zhang

Leng

et al. 2017

J Cellular Molecular Medi

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To explore the association of LEP and leptin receptor (LEPR) gene single‐nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese population. Four LEP SNPs (rs11761556, rs12706832, rs2071045 and rs2167270) and nine LEPR SNPs (rs10749754, rs1137100, rs1137101, rs13306519, rs8179183, rs1805096, rs3790434, rs3806318 and rs7518632) were genotyped in a cohort of 633 patients with SLE and 559 healthy controls. Genotyping of SNPs was performed with improved multiple ligase detection reaction (iMLDR). No significant differences were detected for the distribution of allele and genotype frequencies of all 13 SNPs between patients with SLE and controls. The genotype effects of recessive, dominant and additive models were also analysed, but no significant evidence for association was detected. However, further analysis in patients with SLE showed that the TT genotype and T allele frequencies of the LEP rs2071045 polymorphism were nominally significantly higher in patients with pericarditis (P = 0.012, P = 0.011, respectively). In LEPR, the GA/AA genotype and A allele frequencies of the rs1137100 polymorphism were both nominally associated with photosensitivity in patients with SLE (P = 0.043, P = 0.018, respectively). Moreover, the genotype and allele distribution of rs3806318 were also nominally associated with photosensitivity in patients with SLE (P = 0.013, P = 0.008, respectively). No significant differences in serum leptin levels were observed in patients with SLE with different genotypes. In summary, LEP and LEPR SNPs are not associated with genetic susceptibility to SLE, but may contribute to some specific clinical phenotype of this disease; further studies are necessary to elucidate the exact role of LEP and LEPR genes in the pathogenesis of SLE.

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“…In patients with SSc, fat mass distribution may be different to that in controls. In particular, patients with SSc display lower subcutaneous adipose tissue accumulation than controls despite having similar BMI, as was also observed in RA patients [65]. This is attributed to skin fibrosis, and attrition of dermal white adipose tissue (dWAT) has been reported to correlate with reduced levels of circulating adiponectin in SSc patients [66].…”

Section: Discussionmentioning

confidence: 81%

Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis

Michalska-Jakubus

Sawicka

Potembska

et al. 2019

pdia

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A b s t r a c tIntroduction: Leptin and adiponectin have recently received the attention of researchers as attractive biomarkers in systemic sclerosis (SSc) because of their role in the inflammatory process, vascular function and fibrosis. We hypothesized that leptin and adiponectin may be associated with disease activity and severity in patients with SSc. Aim: To compare serum leptin, adiponectin and leptin/adiponectin levels in patients with SSc and healthy controls and to evaluate their possible relationship with frequently used laboratory markers and clinical findings. Material and methods: The study included 48 Caucasian female patients with SSc and 38 healthy controls. Serum concentrations of leptin and adiponectin were measured in patients and controls using commercially available ELISA Kits (Quantikine ELISA Kit R&D Systems, Minneapolis, MN, USA). The results were assessed by the Mann-Whitney U-test and Spearman's correlation test. Results: Leptin and adiponectin levels correlated with body mas index SSc patients (r = 0.495, p = 0.000398 and r = -0.306; p = 0.0342) in contrast to healthy controls (p = 0.070 and p = 0.256, respectively), and, in SSc patients only, a strong negative correlation was observed between leptin and adiponectin serum levels (r = -0.314; p = 0.0312). Diffuse form of the disease (dcSSc) was associated with significantly lower serum adiponectin levels (8638.62 ±10382.62). Active disease was associated with significantly lower leptin concentration (13700.49 ±18293.32) and there was a significant negative correlation between leptin serum level and activity index score (r = -0.342; p = 0.0185). Conclusions:The results of our study indicate that leptin levels might correlate with disease activity and subtype in SSc patients.

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Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies

Cited by 16 publications

References 47 publications

Association of Body Dysmorphic Disorder with Leptin Levels in Patients with Normal Weight Undergoing Liposuction: A Matched Case Study

Association of Body Dysmorphic Disorder with Leptin Levels in Patients with Normal Weight Undergoing Liposuction: A Matched Case Study

Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population

Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis

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