Serum lactic dehydrogenase as a prognostic tool for non-Hodgkin lymphomas

Ferraris, AM; Giuntini, Patrizia; Gaetani, Gian Franco

doi:10.1182/blood.v54.4.928.bloodjournal544928

Cited by 51 publications

(19 citation statements)

References 4 publications

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“…Serum LDH levels also have momentous significance in cancer diagnosis due to tissue destruction caused by tumor growth . In general, serum LDH is usually elevated in hematopoietic malignancies such as Hodgkin's lymphoma (HL) and non‐Hodgkin's lymphoma (NHL) . Colgan et al found that surgical removal of the primary tumor resulted in a dramatic decrease in serum LDH levels within first week after surgery.…”

Section: Ldha As a Biomarker And Therpeutic Target For Cancermentioning

confidence: 99%

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

et al. 2018

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Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research. First, we gave an introduction of structure, location, and basic function of LDHA. Following, we discussed the transcription and activation mode of LDHA. Further, we focused on the function of LDHA in cancer bio‐characteristics. Later, we discussed the clinical practice of LDHA in cancer prevention and treatment. What we discussed gives a precise insight into LDHA especially in cancer research, which will contribute to exploring cancer pathogenesis and its handling measures.

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Section: Ldha As a Biomarker And Therpeutic Target For Cancermentioning

confidence: 99%

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

et al. 2018

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“…As a general consideration, high levels of LDH are mostly found in heart, liver, erythrocytes, skeletal muscles and kidneys. Although high levels of LDH are known to be associated with poor prognosis in both children and adults with lymphoma [9,10,11], its significance in patients who had undergone alloHSCT still remains unclear. The analysis of pretransplant serum LDH is considerably easy and unexpensive method so, this might be used to show patients with high risk prior to the transplantation.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Pretransplant Serum Lactate Dehydrogenase (LDH) Levels for Survival in Patients who have undergone Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT)

Şıvgın¹,

Ozenmis²,

Kaynar³

2012

J Stem Cell Res Ther

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Objectives and aim: Our objective was to investigate the association of pre-transplant Lactate Dehydrogenase (LDH) levels with complications and survival following allogeneic Hematopoietic Stem Cell transplantation (alloHSCT). Materials and methods: We retrospectively analyzed data of 156 patients who had undergone alloHSCT from 2004 to 2010 in Dedeman Stem Cell Transplantation Hospital, Kayseri, Turkey. Pretransplant serum lactate dehydrogenase (LDH), alkaline phosphatase (ALP), creatinin and fibrinogen levels drawn within 7 days prior to transplantation were analyzed with data of transplant procedures. Results: 63 (40.3%) of the patients were female, while 93 (59.7%) were male. The median age was 26 years (min-max:13-57). The median pretransplant serum levels of; LDH was 202U/L (min-max: 71-1202), alkaline phosphatase 83.0 U/L (min-max: 21-379), creatinin 0.70mg/dL (min-max: 0.30-2.40), and fibrinogen 293mg/dL (minmax: 7.0-566.0); respectively. Univariate and multivariate analysis showed that high pre-transplant LDH levels (≥ 246ng /mL) were significantly correlated with decreased disease-free survival (DFS) rates (p=0.037). A higher risk of death was observed in high LDH group both in univariate and multivariate analysis (hazard ratio=2.27, CI: 1.06-3.57 and hazard ratio=1.94, CI: 1.06-3.57; respectively). In univariate analysis; although there was a correlation between high serum LDH levels and decreased rates of OS, this was not statistically significant (hazard ratio=1.31, CI: 0.80-2.13, p=0.286). There was no statistically significant difference among groups for the parameters ALP, creatinin, CD 34 + cell count, age, gender and diagnosis (p > 0.05). Conclusion: Pre-transplant increased serum LDH levels may be associated with poor survival in patients who have undergone allogeneic hematopoietic stem cell transplantation.

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“…Determination of serum LDH levels is a well‐known diagnostic tool in human oncology 4–10 and, occasionally, measurement of LDH levels failed to show specificity in human cancer patients. For instance, high LDH levels in melanoma patients do not necessarily indicate a more advanced disease, thereby possibly leading to false‐positive results if not cautiously interpreted during initial staging work‐up 34 …”

Section: Discussionmentioning

confidence: 99%

“…Additionally, LDH is one of the most common enzymes used in cancer patients for prognostic purposes, as its increase reflects tumour burden and treatment response. Indeed, LDH is considered as an important prognostic marker in lymphoma, 4,5 leukaemia, 6,7 germ cell tumours 8 and melanoma, 9,10 among others. Interestingly, serum measurement of LDH also helps in differentiating cancer from benign neoplasia, including uterine leiomyosarcoma from leiomyoma 11 and ovarian carcinoma from benign epithelial ovarian tumours 12…”

Section: Introductionmentioning

confidence: 99%

Serum lactate dehydrogenase activity in canine malignancies

Marconato

Crispino

Finotello

et al. 2009

Vet Comparative Oncology

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LDH is commonly used in human cancer patients for prognostic purposes. Aim of this study was to determine the magnitude of serum LDH elevation in dogs with cancer compared to healthy dogs and dogs with non-neoplastic disease, and to verify whether it may support the diagnosis of specific malignancies. 128 healthy dogs, 211 diseased dogs and 188 cancer dogs were enrolled. Dogs with cancer had significantly higher LDH than diseased (P<0.001) and healthy dogs (P<0.001), but large overlap was found.Dogs with lymphoma showed significantly higher LDH compared to dogs with carcinoma (P<0.001) or mast cell tumor (MCT; P<0.05) but not compared to other malignancies. When considering lymphoma and MCT, LDH levels were not different between early and advanced clinical stages. Measuring LDH levels may not be useful as a screening tool for cancer detection. More studies are needed to define its role in specific tumors.

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Serum lactic dehydrogenase as a prognostic tool for non-Hodgkin lymphomas

Cited by 51 publications

References 4 publications

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

Predictive Value of Pretransplant Serum Lactate Dehydrogenase (LDH) Levels for Survival in Patients who have undergone Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT)

Serum lactate dehydrogenase activity in canine malignancies

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