Serum lactate in liver resection with intermittent Pringle maneuver: the “square‐root‐ shape

Abstract

Lactatemia during liver resection depends on the duration of PM, bleeding and the duration of the operation. Normal liver may expose the patient to the risk of hyperlactatemia.

Lactate, lactate clearance and outcome after cardiac arrest: A post‐hoc analysis of the TTM‐Trial

“…For example, both referred studies consisted of patients presenting with predominantly non‐shockable rhythms and one of them included in‐hospital cardiac arrest patients, which may have confounded the results. The 12‐hour lactate level after OHCA is theoretically interesting as it can be viewed as a composite of both production and clearance of lactate, thus adding the influence of post‐arrest factors like hemodynamic status, seizures, and liver function . The 12‐hour lactate level in this study was an independent predictor of outcome.…”

Serum Lactate in Liver Resection Surgery. A Mini-Review

“…The peculiar significant difference in lactate clearance associated with different duration of PM (i.e. longer or shorter than 76 minutes) was observed after the first two postoperative hours [27]. Furthermore, to date, the correlation between the length of the operation and postoperative sLac has not been clearly investigated.…”

Perioperative Management of Complex Hepatectomy for Colorectal Liver Metastases: The Alliance between the Surgeon and the Anesthetist

“…In a previous report, we found a peculiar trend of early postoperative serum lactate concentration. Whatever the PM duration (more or less than 76 min), the postoperative clearance of serum lactate exhibited a particular curve shape that we named the “square root” shape as it draws a line which reminds us of the mathematical sign of the square root ( Figure 2 ) [ 46 ].…”

“…cLac , serum lactate clearance; cPT, cumulative Pringle maneuver time. Reprinted with permission from reference [ 46 ].…”

“…This is even more essential if we consider that all general anesthesia techniques in the absence of surgical stimulation reduce the hepatic blood flow by about 30% [43]. root" shape as it draws a line which reminds us of the mathematical sign of the square root (Figure 2) [46]. In any case, perioperative management of lactic acidosis, especially when associated with severe acidemia, is an inseparable part of anesthesia, postoperative and critical care management since it presents a variety of challenges.…”