Serum Lactate Dehydrogenase Level in Patients with Nasopharyngeal Carcinoma

Liaw, Chuang-Chi; Wang, Cheng‐Hsu; Huang, Jian-Jia; Kiu, Mee-Chou; Chen, Jen‐Shi; Chang, Hsien-Khun

doi:10.3109/02841869709109224

Cited by 40 publications

(27 citation statements)

References 14 publications

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“…High LDH5 expression was linked with tumor infiltration into adjacent structures (T4), suggesting that LDH5 promotes local invasive abilities compatible with the known induction of stromalytic proteins under acidic conditions [19,20]. A significant association of high LDH5 with death from distant metastasis also stresses the importance of the enzyme in the metastatic process, confirming the close link of high serum LDH with metastasis shown in previous studies [23,25]. …”

Section: Discussionsupporting

confidence: 67%

“…Singh et al [22] reported a study on HNC patients, in which high LDH serum levels were linked with poor histological differentiation and metastasis. The increased incidence of metastatic disease in nasopharyngeal cancer patients with high serum LDH levels has also been confirmed in subsequent studies [23,24,25]. High LDH serum levels are also an important factor predicting locoregional control of nasopharyngeal cancer following conformal radiotherapy [26].…”

Section: Discussionmentioning

confidence: 61%

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Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy

et al. 2009

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Objectives: We assessed the expression and the prognostic role of lactate dehydrogenase 5 (LDH5, the major LDH isoenzyme involved in anaerobic glycolysis) in patients with squamous cell head and neck cancer (SCHNC). Methods: LDH5 was assessed immunohistochemically in whole tissue sections from 141 patients with SCHNC. Of these, 102 were subjected to surgery with (90 patients) or without (12 patients) postoperative radiotherapy (group A), while 39 patients were treated with radical radiotherapy (group B). Results: Mixed nuclear/cytoplasmic LDH5 expression was detected in 72.5% of group A and 61.5% of group B patients. This was significantly related to T4-stage (p = 0.04) and hypoxia-inducible factor-1α (HIF-1α) expression (p = 0.002). In group A, high LDH5 was linked with poorer distant metastasis-free survival (p = 0.01) and disease-specific overall survival (OS; p = 0.009). In multivariate analysis, LDH5 (p = 0.002) and HIF-1α (p = 0.01) were independently linked with distant metastasis. LDH5 was also linked with death events (p = 0.005). In group B, high LDH5 expression was significantly associated with poorer local relapse-free survival (p = 0.009) and OS (p = 0.01). In multivariate analysis, only T stage was a significant predictor of death events (p = 0.04). Conclusions: LDH5 is highly expressed in SCHNC and is linked with local relapse, survival and distant metastasis, suggesting that LDH5 is a marker of radioresistance and a target for therapeutic interventions.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 61%

Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy

et al. 2009

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“…Cases with normal serum LDH before treatment had a better chance of survival than those with elevated levels. [16] Similarly, even we observed increased levels of serum LDH in patients with OSCC and the levels correlated positively with the clinical stage of the disease. In the current study, estimation of serum LDH was performed only at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 75%

Estimation of serum lactate dehydrogenase level in patients with oral premalignant lesions/conditions and oral squamous cell carcinoma: A clinicopathological study

2015

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“…Elevated levels of LDH also demonstrated as a negative prognostic factor, which may be associated with large tumor burden, tumor extension and high risk of metastasis [18]–[20]. Serum LDH levels twice normal levels are rarely seen in loco-regional disease but are commonly observed in NPC patients with liver metastasis or multiple organ metastases.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of 234 Nasopharyngeal Carcinoma Patients with Distant Metastasis at Initial Diagnosis: Therapeutic Approaches and Prognostic Factors

et al. 2014

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PurposeThe purpose of this retrospective study was to identify the independent prognostic factors and optimize the treatment for nasopharyngeal carcinoma (NPC) patients with distant metastasis at initial diagnosis.MethodsA total of 234 patients referred between January 2001 and December 2010 were retrospectively analyzed. Among the 234 patients, 94 patients received chemotherapy alone (CT), and 140 patients received chemoradiotherapy (CRT). Clinical features, laboratory parameters and treatment modality were examined with univariate and multivariate analyses.ResultsThe median overall survival (OS) time was 22 months (range, 2-125 months), and the 1-year, 2-year, 3-year overall survival rates were 82.2%, 51.3% and 34.1%. The overall response and disease control rates of metastatic lesions after chemotherapy were 56.0% and 89.8%. The factors associated with poor response were karnofsky performance score (KPS) <80, liver metastasis, lactate dehydrogenase (LDH)>245 IU/L, and number of chemotherapy cycles <4. The 3-year OS of patients receiving CRT was higher than those receiving CT alone (48.2% vs. 12.4%, p<0.001). Subgroup analysis showed that significantly improved survival was also achieved by radiotherapy of the primary tumor in patients who achieved complete remission (CR)/partial remission (PR) or stable disease (SD) of metastatic lesions after chemotherapy. Significant independent prognostic factors of OS were KPS, liver metastasis, levels of LDH, and multiple metastases. Treatment modality, response to chemotherapy and chemotherapy cycles were also associated with OS.ConclusionA combination of radiotherapy and chemotherapy seems to have survival benefits for selected patients with distant metastases at initial diagnosis. Clinical and laboratory characteristics can help to guide treatment selection. Prospective randomized studies are needed to confirm the result.

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Serum Lactate Dehydrogenase Level in Patients with Nasopharyngeal Carcinoma

Cited by 40 publications

References 14 publications

Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy

Lactate Dehydrogenase 5 Expression in Squamous Cell Head and Neck Cancer Relates to Prognosis following Radical or Postoperative Radiotherapy

Estimation of serum lactate dehydrogenase level in patients with oral premalignant lesions/conditions and oral squamous cell carcinoma: A clinicopathological study

Retrospective Analysis of 234 Nasopharyngeal Carcinoma Patients with Distant Metastasis at Initial Diagnosis: Therapeutic Approaches and Prognostic Factors

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