Serum lactate dehydrogenase (LDH) level in mild and severe preeclampsia as a prognostic marker

Abstract

Background: Lactate Dehydrogenase (LDH) is mainly an intracellular enzyme. Its level is an useful biomarker for cellular injury which may suggested as a potential marker to predict the severity of preeclampsia and indicator for multi-organ involvement have significant role in management of preeclampsia. We conducted this study to examine the relationship between lactate dehydrogenase concentration and the severity of the disease and occurrence of complications. The objective of the present study was to assess role of serum LDH level in mild and severe preeclamptic women Methods: This prospective study was conducted in the Department of obstetrics and gynecology in Jhalawar medical college from Jan 2017 to Oct 2017 Total 120 pregnant women during third trimester (32-40 weeks) aged 18 to 35 years were selected. Among them 40 were severe preeclampsia and 40 were mild preeclampsia patients and 40 were healthy normotensive control. Serum LDH level was estimated by continuous spectrophotometric method. Demographic, hemodynamic, and laboratory data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with foetal outcome were analyzed according to the levels of LDH. Results: In this study, serum LDH level was significantly higher (P<0.001) in preeclamptic compared to those of control. Again, this value was significantly higher in severe preeclamptic than those of mild preeclamptic. The symptoms and complications of preeclampsia along with perinatal mortality were increased significantly in patents with LDH> 800IU/I compared with those who had lower levels. Conclusions: From this study, it can be concluded that elevated serum LDH level is associated with severity of preeclampsia. LDH has been evaluated as a biochemical marker for preeclampsia and as a prognosticator of the disease severity. Detection of high-risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

Maternal serum lactate dehydrogenase level and adverse pregnancy outcomes in women with hypertensive disorder of pregnancy at a tertiary care centre: a retrospective study

“…However, the present study and the study conducted by Bairwa et al in 2018 in Rajasthan reported deaths at S. LDH levels of around 600 IU/l as well. 15 Now, though there are various studies in this regard, most of their statistical significance is not proven unlike the present study where the association between S. LDH levels and PNMR is shown to be significant. Strength of the study is that, it provides a basic framework for planning and conducting further studies.…”