Serum Lactate Dehydrogenase Is a Sensitive Predictor of Systemic Complications of Acute Pancreatitis

Abstract

Background. Acute pancreatitis (AP) is a common and potentially life-threatening inflammatory disease that can cause various complications, including systemic inflammatory response syndrome (SIRS), pleural effusion, ascitic fluid, myocardial infarction, and acute kidney injury (AKI). However, there is still a lack of rapid and effective indicators to assess the disease. The aim of this study was to investigate the associations of high serum lactate dehydrogenase (LDH) levels with AP severity and systemic complications. Methods. AP patients treated from July 2014 to December 2020 were retrospectively enrolled. They were divided into elevated ( n = 93 ) and normal ( n = 143 ) LDH groups. Their demographic data, clinical data, hospital duration, and hospital expenses were analyzed. Linear and binary logistic regression analyses were used to determine whether elevated LDH is a risk factor for AP severity and complications after adjusting for confounders. Results. There were significant differences in AP severity scores (Ranson, MODS, BISAP, APACHE II, and CTSI), hospital duration, hospital expenses, and the incidences of complications (SIRS, pleural effusion, ascitic fluid, myocardial infarction, and AKI) between the elevated and normal LDH groups. After adjusting for confounders, elevated LDH was associated with AP severity scores and hospital duration and expenses (based on linear regression analyses) and was a risk factor for the occurrence of AP complications and interventions, that is, diuretic and vasoactive agent use (based on binary logistic regression analyses). Conclusions. Elevated LDH is associated with high AP severity scores and high incidences of complications (SIRS, pleural effusion, ascitic fluid, myocardial infarction, and AKI).

Ferritin and Ferritin-to-Hemoglobin Ratio as Promising Prognostic Biomarkers of Severity in Acute Pancreatitis—A Cohort Study

“…Similar to previously published studies, in our research, LDH was correlated with organ failure, since it was suggested that pancreas dysfunction was not the initial cause for the raised LDH levels, but the kidney dysfunction should be considered [19].…”

Incidence and prognostic role of pleural effusion in patients with acute pancreatitis: a meta-analysis

“…Additionally, PE was detected by chest X-ray in eight studies [ 16 , 18 , 20 , 22–24 , 41 , 50 ], by CT in 14 studies [ 19 , 21 , 25–27 , 30 , 32 , 35 , 38 , 39 , 42 , 45–47 ], by transthoracic sonography in one study [ 17 ] and by combination of above methods in four studies [ 29 , 31 , 48 , 49 ]. Other studies did not clearly report the detecting method [ 28 , 33 , 34 , 36 , 37 , 40 , 43 , 44 ]. The general characteristics of the eligible studies are shown in Table 1 .…”

Một Số Yếu Tố Dự Đoán Mức Độ Nặng Của Bệnh Nhân Viêm Tụy Cấp

“…Creatinine máu tăng cao trong vòng 48 giờ đầu tiên có thể dự đoán sự phát triển của hoại tử tuyến tụy. Tian thấy rằng mức độ LDH ở bệnh nhân AP nặng cao hơn khoảng hai lần so với bệnh nhân AP nhẹ và tác giả báo cáo rằng LDH là yếu tố dự đoán đáng tin cậy của AP nặng (độ nhạy 82,7% và độ đặc hiệu 96%) [9]. Ngoài ra, một mô hình sử dụng LDH để dự đoán AP nặng, cho thấy 63,6% bệnh nhân được xác định là mắc AP nặng tại LDH> 536 U/L và độ chính xác tổng thể của mô hình là 88,5%.…”