Serum lactate as predictor and diagnostic biomarker of plasma leakage in adult dengue patients

Bur, Rika; Suwarto, Suhendro; Santoso, Widayat Djoko; Harimurti, Kuntjoro

doi:10.18051/univmed.2016.v35.213-221

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Early recognition of plasma leakage can lead to appropriate fluid administration and then prevent the development of DSS, which is the most common cause of death from dengue [3][4][5][6][7]. However, most previous studies regarding plasma leakage predictors have varied results due to differences in study design, participant composition, and case definition of severe manifestations of dengue [8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Plos Onementioning

confidence: 99%

“…However, studies reported on different parameters, including demographic characteristics of older age [8][9][10][11], gender [8,11], ethnicity [11], diabetes mellitus [9,[10][11][12], hypertension [11], delayed hospitalization [9], secondary infection [9], clinical parameters of bleeding [8], abdominal pain [8,10], lethargy [8,9], or cough [8], and laboratory findings of hematocrit (HCT) rising [12][13][14], thrombocytopenia [13,15], abnormal coagulation profile [14], raised liver enzymes [12,13], low serum albumin (ALB) level [13,15], or thickening of the gall bladder wall [9]. Recent studies have added several new parameters, including procalcitonin [16], lactate [16,17], chymase [18], and cytokines [19], as plasma leakage predictors among dengue patients aged �15 years.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis

et al. 2021

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Delayed plasma leakage recognition could lead to improper fluid administration resulting in dengue shock syndrome, subsequently, multi-organ failure, and death. This prospective observational study was conducted in Bangkok, Thailand, between March 2018 and February 2020 to determine predictors of plasma leakage and develop a plasma leakage predictive score among dengue patients aged ≥15 years. Of 667 confirmed dengue patients, 318 (47.7%) developed plasma leakage, and 349 (52.3%) had no plasma leakage. Multivariate analysis showed three independent factors associated with plasma leakage, including body mass index ≥25.0 kg/m2 (odds ratio [OR] = 1.784; 95% confidence interval [CI] = 1.040–3.057; P = 0.035), platelet count <100,000/mm3 on fever days 3 to 4 (OR = 2.151; 95% CI = 1.269–3.647; P = 0.004), and aspartate aminotransferase or alanine aminotransferase ≥100 U/l on fever days 3 to 4 (OR = 2.189; 95% CI = 1.231–3.891; P = 0.008). Because these three parameters had evidence of equality, each independent factor was weighted to give a score of 1 with a total plasma-leak score of 3. Higher scores were associated with increased plasma leakage occurrence, with ORs of 2.017 (95% CI = 1.052–3.869; P = 0.035) for score 1, 6.158 (95% CI = 2.914–13.015; P <0.001) for score 2, and 6.300 (95% CI = 2.419–16.407; P <0.001) for score 3. The area under the receiver operating characteristics curves for predicting plasma leakage was good (0.677 [95% CI = 0.616–0.739]). Patients with a plasma-leak score ≥1 had high sensitivity (88.8%), and those with a plasma-leak score of 3 had high specificity (93.4%) for plasma leakage occurrence. This simple and easily accessible clinical score might help physicians provide early and timely appropriate clinical dengue management in endemic areas.

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Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis

et al. 2021

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“…The separated serum samples were refrigerated (2 -8 o C) and/ or stored frozen (≤ -20 o C) for further analysis. Since, there was no direct involvement of the subjects in the current study, informed consent from cases and controls were not applied [11], and no ethical clearance was made because of the retrospective procurement of samples utilized in the current study [12].…”

Section: Serum Samplesmentioning

confidence: 99%

Diagnosis of Dengue Infection Cases by Serum Lactate Dehydrogenase Profiling Compared to Dengue NS1 Antigen and Anti-dengue IgM Antibody Detection: A Retrospective Study

Mandal¹,

Ghosh²,

Halder³

et al. 2018

acta scient microb

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The serum LDH (lactate dehydrogenase) levels have been reported to be increased in DF, and studies showed that LDH levels are higher in DHF and DSS cases [7], while an early elevation of LDH was recorded as an independent predictor of DHF [8]. As per the report of Perveen., et al. [9], at the time of hospital stay, patients having DHF had higher level of LDH, compared to the patients with DF. The LDH level was found to be increased in dengue cases (563 U/L), compared to normal individuals (160 -320 U/L), as has been reported by Shameemunnisa and Jenith [10]. Thus, the higher serum LDH levels have been considered to be the diagnostic markers Dengue, which is a mosquito-borne disease vectored principally AbstractKeywords: Dengue; NS1 Antigen; Anti-DENV IgM Antibody; ELISA; Serum Lactate Dehydrogenase; PAGE Analysis Dengue is an acute infection with potential fatal complications; the specific antibody detection for which is an indirect method, and the novel parameter NS1 is reliable for diagnosis of dengue infection, while the serum LDH has been reported to be elevated in severe dengue. This study attempts to evaluate the association of serum LDH with NS1 antigen and IgM in dengue. The serum NS1and IgM of dengue cases, by ELISA, were estimated from index values by dividing absorbance at 450 nm with cut-off values. Total LDH was measured using autoanalyzer. Electropherotyping of LDH was done in 7.5% polyacrylamide gels. The NS1 and IgM parameters were compared with LDH levels, and analyzed statistically. The NS1 antigens were 35.23 ± 5.37 U (normal < 9 U) with 634.67 ± 350.55 U/L LDH (normal ≤250 U/L) (r = -0.57) among 32.33 ± 7.13 years patients and IgM antibodies were 52.38 ± 7.68 U with 451.67 ± 119.74 U/L LDH (r = -0.13) among 25.92 ± 5.01 years patients. The electropherotype showed intense and greater band pattern when IgM was detected compared to NS1 antigen. Appearance of dengue NS1 antigen as well as anti-dengue IgM in the early phase of infection was inversely related to the level of serum LDH, and increased LDH activity was found when IgM was detected.Thus, LDH might be useful as predictive tool in the early course of dengue infection.

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“…In current clinical practice, there is no reliable clinical and biochemical parameter used to predict severe DF. Plasma lactate is frequently used as a monitoring marker in suspected severe cases but its sensitivity and specificity in predicting disease progression and outcome is poor (Bur et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin and Clinical Factors Associated with Severe Dengue Infection in Hospitalized Adults in Malaysia

Sani¹,

Syazana²,

Izuan³

et al. 2019

American Journal of Infectious Diseases

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Serum lactate as predictor and diagnostic biomarker of plasma leakage in adult dengue patients

Cited by 4 publications

References 21 publications

Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis

Predictors of plasma leakage among dengue patients in Thailand: A plasma-leak score analysis

Diagnosis of Dengue Infection Cases by Serum Lactate Dehydrogenase Profiling Compared to Dengue NS1 Antigen and Anti-dengue IgM Antibody Detection: A Retrospective Study

Procalcitonin and Clinical Factors Associated with Severe Dengue Infection in Hospitalized Adults in Malaysia

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