Serum lactate/albumin ratio as a predictor of morbidity and mortality in patients with severe sepsis and septic shock.

aboraya, karim; Makram, E.F.; Ibrahim, Mohamed; Rahman, Ahmed Abdel

doi:10.21608/bmfj.2020.19931.1171

Cited by 1 publication

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“…Since each of the two parameters independently predicts mortality, a combination of both seems to be useful in order to further increase the predictive value 28 . The L/A ratio may be a reasonable prognostic marker of sepsis considering that there are many physiological changes that need to be taken into consideration during sepsis; however, the use of the L/A ratio will require further validation prior to clinical application 29 – 31 . A study by Bou Chebl et al 32 , showed that the L/A ratio has better prognostic performance than initial serum lactate for in-hospital mortality in adult septic patients.…”

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confidence: 99%

Comparison of lactate/albumin ratio to lactate and lactate clearance for predicting outcomes in patients with septic shock admitted to intensive care unit: an observational study

Shadvar

Nader

Vahed

et al. 2022

Sci Rep

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The aim of this study was to evaluate the prognostic value of the Lactate to Albumin (L/A) ratio compared to that of lactate and lactate clearance in predicting outcomes in patients with septic shock. This was a multi-center observational study of adult patients with septic shock, who admitted to intensive care units (ICUs) at Shohada and Imam Reza Hospitals, Tabriz, Iran, between Sept 2018 and Jan 2021. The area under the curve (AUC) of receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to explore associations of the L/A ratio, lactate and lactate clearance on the primary (mortality) and secondary outcomes [ICU length of stay (LOS), duration of mechanical ventilation (MV), need of renal replacement therapy (RRT) and duration of using vasopressors] at baseline, 6 h and 24 h of septic shock recognition. Best performing predictive value for mortality were related to lactate clearance at 24 h, L/A ratio at 6 h and lactate levels at 24 h with (AUC 0.963, 95% CI 0.918–0.987, P < 0.001), (AUC 0.917, 95% CI 0.861–0.956, P < 0.001), and (AUC 0.904, 95% CI 0.845–0.946, P < 0.001), respectively. Generally, the lactate clearance at 24 h had better prognostic performance for mortality and duration of using vasopressor. However, the L/A ratio had better prognostic performance than serum lactate and lactate clearance for RRT, ICU LOS and MV duration.

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