Serum ?-L-fucosidase activity and early detection of hepatocellular carcinoma

Giardina, M. G.; Matarazzo, Margherita; Morante, R; Lucariello, A; Varriale, Antonio; Guardasole, Vincenzo; Marco, G. De

doi:10.1002/(sici)1097-0142(19981215)83:12<2468::aid-cncr9>3.0.co;2-y

Cited by 81 publications

(42 citation statements)

References 22 publications

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“…The role of FADS2 in HCC has not been studied yet, but there is a possibility that FADS2-mediated arachidonic acid may be involved in early carcinogenesis (42). Serum activity of ·-L-fucosidase was previously reported as a potential marker of HCC (43,44). New kinetic assay of ·-Lfucosidase showed promising results with sensitivity and specificity better than AFP (45).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of hepatitis B virus-associated small hepatocellular carcinoma by serial analysis of gene expression

Kim

Lee²,

Park³

et al. 2009

Int J Oncol

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Abstract. Serial analysis of gene expression (SAGE) is a sequence-based tool that enables quantitative study of comprehensive gene expression profiles. In this study, we generated a SAGE library of hepatitis B virus (HBV)-associated small hepatocellular carcinoma (HCC) and compared it with libraries of normal liver and other organs in order to identify genes which are specifically expressed in HBV-associated small HCC. A total of 18,107 SAGE tags were obtained from the HCC SAGE library. Among the 7,405 unique tags, 240 were significantly overexpressed in HCC compared to normal liver. Seventeen genes were unequivocally matched to SAGE tags which were up-regulated 15-fold or higher in HCC compared to normal liver: four genes (fatty acid desaturase 2, ·-L-2-fucosidase, testis-specific protein Y-encoded-like 2 and Gon-4-like) were significantly overexpressed in the HCC SAGE library compared to any other SAGE libraries of human normal tissues. The significance of these genes with respect to carcinogenesis and early diagnosis of HCC needs to be elucidated in further studies.

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Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of hepatitis B virus-associated small hepatocellular carcinoma by serial analysis of gene expression

Kim

Lee²,

Park³

et al. 2009

Int J Oncol

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“…A screening test should be able to identify early disease, not late disease. Other tests that have been reported as screening tests included the ratio of glycosylated AFP (L3 fraction) to total AFP, 128-134 alpha fucosidase 135,136 and glypican 3. 137,138 None of these has been adequately investigated and cannot be recommended as a screening test.…”

Section: Surveillance Testsmentioning

confidence: 99%

Management of hepatocellular carcinoma

2005

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“…Previous studies have found increased AFU serum levels in patients with cirrhosis and HCC. 14,15 Arginase is a hydrolase typically found in the liver, where it catalyzes the final reaction in the synthesis of urea, the so-called livertype arginase. 16 Concurrently, the rise of extrahepatic arginase can increase the level of polyamines, compounds crucial for cell proliferation.…”

Section: Introductionmentioning

confidence: 99%