Serum-Kreatin-Phosphokinase: Bestimmung und diagnostische Bedeutung

Serum Creatine Phosphokinase and α-Hydroxybutyric Dehydrogenase Activities Compared With GOT and LDH in Myocardial Infarction

“…On the other hand, under similar conditions of muscular exercise the serum GOT and malic dehydrogenase showed no change, and the eleva- (Numerals in parentheses denote number of samples) tion in serum LDH, sorbitol dehydrogenase and aldolase showed only moderate elevation (1(5). The increment in serum CPK in connection with muscular exercise may be caused by the release of this enzyme from striated muscles, where it is especially abun dant (11,17). Furthermore, the serum CPK activity seems to reach a high level at delivery, possibly as a result of labour (18).…”

Creatine Phosphokinase in Cerebrospinal Fluid

“…Its concentration in cerebellar white matter is relatively low (Colombo et al, 1962) The former study (Herschkowitz, 1964) further cites the usefulness of determinations of the enzyme in distinguishing symptomatic from idiopathic epilepsy. We studied six cases of idiopathic epilepsy and found normal enzyme levels in four.…”

“…Dreyfus, Schapira, and Demos (1960) have recently pointed out the advantage of determining serum levels of this enzyme in the investigation of muscle disease. Colombo et al (1962), Hughes (1963), and others (Ebashi, Toyokura, Momoi, and Sugita, 1959), have found high levels of creatine phosphokinase in the serum of patients with progressive muscular dystrophy. These levels may also be useful in the diagnosis of acute myocardial infarction, especially in differentiating between myocardial and pulmonary infarction (Dreyfus, Schapira, Resnais, and Scebet, 1960;Stich and Tsirimbas, 1962).…”

“…Creatine Phosphate + ADP = Creatine + ATP Creatine phosphokinase exists in greatest concentration in skeletal muscle tissue, followed by brain and heart (Colombo, Richterich, and Rossi, 1962). Recent work has demonstrated the presence of several isoenzymes of creatine phosphokinase in heart, skeletal muscle, and brain (Burger, Richterich, and Aebi, 1964;Sjovall and Voigt, 1964).…”

Clinical Significance of Serum Creatine Phosphokinase Activity in Cerebrovascular Diseases

“…It seems quite reasonable to interpret a high serum CPK level in patients with chronic muscle diseases such as progressive muscular dystrophy and dermatomyositis as an accumulation of the enzyme due to impairment of enzyme elimination for a long period. But, serum CPK level was also found to rise temporarily after needle electromyographic examination (Cherington et al 1968) or strenuous exercise (Colombo et al 1962). It is unlikely that disapperance rate of CPK from plasma can be altered under such a mild pathophysiological condition.…”