Serum kisspeptin, to discriminate between ectopic pregnancy, miscarriage and first trimester pregnancy

Yüksel, Semra; Gencer, Fatma Ketenci

doi:10.1080/01443615.2022.2028747

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…Accordingly, different biomarkers have been investigated in an attempt to improve the diagnostic accuracy of EP, including kisspeptin. Some studies have found that kisspeptin levels in EP are lower than in healthy pregnancy but higher than in miscarriage (25,26). However, another study demonstrated that kisspeptin levels are not significantly altered between women with viable intrauterine pregnancies (VIUPs) and those with either EP or failing or persistent PUL, after adjusting for confounding variables (20) (Table 2.2).…”

Section: Kisspeptin In Ectopic Pregnancymentioning

confidence: 99%

“…Kisspeptin levels (adjusted for gestation) are markedly reduced by 60-79% in women with miscarriage compared to healthy pregnancy ( 20 – 25 ) ( Table 2.1 ). Above average levels, when corrected for gestational age, are reassuring with a <1% chance of miscarriage ( 20 ), whereas kisspeptin levels 95% lower than the median for that gestation are associated with up to an 85% chance of miscarriage.…”

Section: Kisspeptin In Pregnancy Complicationsmentioning

confidence: 99%

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Kisspeptin in the Prediction of Pregnancy Complications

et al. 2022

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Kisspeptin and its receptor are central to reproductive health acting as key regulators of the reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator of gonadotrophin releasing hormone (GnRH) neuronal function. However, recent evidence has demonstrated that kisspeptin and its receptor also play a fundamental role during pregnancy in the regulation of placentation. Kisspeptin is abundantly expressed in syncytiotrophoblasts, and its receptor in both cyto- and syncytio-trophoblasts. Circulating levels of kisspeptin rise dramatically during healthy pregnancy, which have been proposed as having potential as a biomarker of placental function. Indeed, alterations in kisspeptin levels are associated with an increased risk of adverse maternal and foetal complications. This review summarises data evaluating kisspeptin’s role as a putative biomarker of pregnancy complications including miscarriage, ectopic pregnancy (EP), preterm birth (PTB), foetal growth restriction (FGR), hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), gestational diabetes mellitus (GDM), and gestational trophoblastic disease (GTD).

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Section: Kisspeptin In Ectopic Pregnancymentioning

confidence: 99%

Section: Kisspeptin In Pregnancy Complicationsmentioning

confidence: 99%

Kisspeptin in the Prediction of Pregnancy Complications

et al. 2022

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“…While some studies have reported low levels of KP in EP ( 206 , 214 ), others did not find any significant differences after adjusting for confounding variables ( 107 ) (see Table 1L ). These differing results are likely due to the early gestational age (GA) at presentation of EP.…”

Section: Clinical Applications Of Kisspeptinmentioning

confidence: 84%

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

et al. 2023

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Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding for KP or NKB signaling were shown to result in congenital hypogonadotropic hypogonadism (CHH) and a failure of pubertal development. Over the past two decades since their discovery, a wealth of evidence from both basic and translational research has laid the foundation for potential therapeutic applications. Beyond KP’s function in the hypothalamus, it is also expressed in the placenta, liver, pancreas, adipose tissue, bone, and limbic regions, giving rise to several avenues of research for use in the diagnosis and treatment of pregnancy, metabolic, liver, bone, and behavioral disorders. The role played by NKB in stimulating the hypothalamic thermoregulatory center to mediate menopausal hot flashes has led to the development of medications that antagonize its action as a novel non-steroidal therapeutic agent for this indication. Furthermore, the ability of NKB antagonism to partially suppress (but not abolish) the reproductive endocrine axis has supported its potential use for the treatment of various reproductive disorders including polycystic ovary syndrome (PCOS), uterine fibroids, and endometriosis. This review will provide a comprehensive up-to-date overview of the preclinical and clinical data that have paved the way for the development of diagnostic and therapeutic applications of KP and NKB.

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“…Despite the fact that the most of research indicates that miscarriages usually occur in the first trimester [ 31 – 36 ]. There is still a significant number of miscarriages in the second trimester, reaching an average of 44 per thousand pregnancies during various gestational stages [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Understanding trimester-specific miscarriage risk in Indian women: insights from the calendar data of National Family Health Survey (NFHS-5) 2019-21

Das,

Patidar,

Singh

2024

BMC Women's Health

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Background The primary public health issue, especially in low- and middle-income countries, is early pregnancy loss driven by miscarriage. Understanding early pregnancy losses and the characteristics of mothers who have miscarriages is essential to creating effective reproductive health strategies. Thus, this study’s primary goal is to delve into the factors which impact miscarriages that take place prior to and following the first 12 weeks of gestation. Methods The bivariate analysis was employed to determine the frequency of miscarriages. The factors associated with miscarriages in the first (≤12 weeks) and second & above (> 12 weeks) trimesters of pregnancy were then examined using a generalised linear regression model, with 95% confidence intervals. Finally, we use ArcGIS to illustrate the prevalence of miscarriage in the districts of India. Results Our result shows that miscarriages occur often in India (4.9%), with 23% of cases occurring in the first trimester (≤12 weeks). In our bivariate analysis, we identified several factors associated with a higher prevalence of miscarriages in India. It was found that mothers aged thirty years or older, residing in urban areas, with less than ten years of education, belonging to the richest wealth quantile, expressing a desire for more children, having no demand for contraception, and possessing no parity experienced a higher prevalence of miscarriage in total pregnancies in India. On the other hand, the generalised linear model’s findings show that mothers who are thirty years of age or older, practise other religions, live in urban areas, are members of other castes, want more children, marry before the age of eighteen, and meet their contraceptive needs are more likely to have miscarriages in total pregnancy. However, there is a larger likelihood of miscarriage in the first trimester (≤12 weeks) for mothers who follow other religions, live in urban areas, are from Other Backward Class (OBC), get married before the age of eighteen, and fall into the middle and upper wealth quantiles. A mother is more likely to miscarriage in the second & above (> 12 weeks) trimesters if she is older than thirty, from other castes, wants more children, has moderate media exposure, marries before turning eighteen, meets her contraceptive needs, and does not feel the need for contraception. After accounting for socioeconomic characteristics, all results were statistically significant. Conclusions Given the substantial number of miscarriages in India, police need to improve planning and guidance in order to lower pregnancy loss due to miscarriage. Miscarriage rates may be significantly decreased by enhancing the availability and quality of reproductive health care infrastructure, particularly in rural areas.

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Serum kisspeptin, to discriminate between ectopic pregnancy, miscarriage and first trimester pregnancy

Cited by 4 publications

References 24 publications

Kisspeptin in the Prediction of Pregnancy Complications

Kisspeptin in the Prediction of Pregnancy Complications

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B

Understanding trimester-specific miscarriage risk in Indian women: insights from the calendar data of National Family Health Survey (NFHS-5) 2019-21

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