Serum kinetics of doxycycline polyphosphate in dogs

Michel, G.; Mosser, J.; Fauran, F

doi:10.1007/bf03189398

Cited by 14 publications

(12 citation statements)

References 12 publications

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“…Doxycycline is highly lipophilic and would be expected to be distributed widely in the chicken. Nevertheless, the V^m*) of 0.28 ± 0.02 I/kg determined in the present study was much lower than that reported for other species: 0.75 I/kg in adult humans (Raghuram & Krishnaswamy, 1982), 1.38 I/kg in calves (Riond et al, 1989), 1.5 to 3.5 I/kg in dogs (Michel et al, 1979), 2.28 I/kg in cows and ewes (Ziv & Sulman, 1974), 4.5 to 7 I/kg in rats (Michel et al, 1984) and 9.78 I/kg in goats (Jha et al, 1989). The lower value of apparent volume of distribution found in the present study may be attributed to higher plasma protein binding, as well as a lower gut reabsorption of drug in the chicken.…”

Section: Discussioncontrasting

confidence: 79%

Pharmacokinetics of doxycycline in broiler chickens

et al. 1994

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SUMMARYDoxycycline was given to two groups of eight chickens at a dose of 20 mg/kg of body weight, intravenously (i.v.) or orally. Plasma concentration was monitored serially for 12 h after each administration. Another group of 30 chickens was given 20 mg/kg orally every 24 h for 4 days, and plasma and tissue concentrations determined serially after the last administration. Concentrations of doxycycline were measured using high-performance liquid chromatography. Pharmacokinetic variables were calculated, using a two-compartment open model. The elimination half-life and the mean residence time for plasma were 6.03 ± 0.45 and 7.48 ± 0.38 h, respectively, after oral administration and 4.75 ±0.21 and 2.87 ±0.11 h, respectively, after i.v. administration. After single oral administration, doxycycline was absorbed rapidly, with T max of 0.35 ± 0.02 h. Maximum plasma concentration was 54.58 ± 2.44 μ/ml. Oral bioavailability of doxycycline was found to be 41.33 ± 2.02%. Doxycycline was widely distributed in tissues and considerable concentrations were found following oral administration of 20 mg/kg on four successive days. The results indicate that doxycycline concentrations were cleared slowly and were at or below the accepted drug tolerance levels in the marker tissues within 5 days after dosing.

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Section: Discussioncontrasting

confidence: 79%

Pharmacokinetics of doxycycline in broiler chickens

et al. 1994

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“…Following a single intravenous administration, a tv2p of 10 h was obtained by graphic determination (Schach von Wittenau & Yeary, 1963), and a harmonic mean of 10.36 h (Wilson et al, 1988) was documented. A t,/:p value of 11.8 h was determined by regression on means of data after a single oral administration (Michel et al, 1979). In dogs, doxycyline tlj2p estimates after a single i.v.…”

Section: Discussionmentioning

confidence: 99%

“…Oral administration of 10mg/kg doxycycline polyphosphate in gelatine capsules to dogs resulted in peak concentrations (Cma,) of 4.6 pg/ml after 2. 8 h (t,,,,,; Michel et al, 1979). Doxycycline bioavailability after oral administration to cats and dogs has not been determined to date.…”

Section: Discussionmentioning

confidence: 99%

Comparative pharmacokinetics of doxycycline in cats and dogs

Riond

Vaden

Riviere

1990

Vet Pharm & Therapeutics

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The disposition of doxycycline hyclate was studied in six adult mixed-breed female cats and six adult mid-sized female dogs following a single intravenous administration of 5 mg/kg body weight. Doxycycline volume of the central compartment, area volume of distribution, volume of distribution at steady state, and total body clearance were significantly smaller in cats. The differences were attributed to more extensive binding of doxycycline to plasma protein including albumin in cats. The significant differences in the volume of distribution and total body clearance were not reflected in elimination half-lives under the conditions of this study (sample size, inhomogeneous population). Doxycycline elimination half-life was 4.56 +/- 0.68 (SEM) h for cats and 6.99 +/- 1.09 h for dogs. Dosage regimens recommended in the veterinary literature were evaluated by the computer program PETDR.

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“…Peak serum concentrations of doxycycline and tetracycline occur 2 to 3 h after oral administration. 1 Doxycycline is at least 5-10 times more lipophilic than tetracycline, resulting in higher tissue penetration and a better overall antimicrobial profile than tetracycline. 2 The elimination mechanism for doxycycline differs from most other tetracyclines as it enters the intestine both by both biliary excretion and by diffusion, 3 with 75% excreted by the biliary route and faeces and urinary excretion accounting for the remainder.…”

mentioning

confidence: 99%

Susceptibility of bacteria from feline and canine urinary tract infections to doxycycline and tetracycline concentrations attained in urine four hours after oral dosage

et al. 2006

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Objectives To measure urinary concentrations of doxycycline in cats and dogs and tetracycline in dogs 4 h after conventional oral dosing and determine whether these antibiotics were present in sufficient concentrations to be effective against common feline and canine urinary tract pathogens as assessed in vitro by Epsilometer and disc diffusion antimicrobial susceptibility methods. Design A prospective study involving oral administration to clinically normal cats and dogs of doxycycline or tetracycline (dogs only) and culture of bacteria from dogs and cats with urinary tract infections to determine their susceptibility to both doxycycline and tetracycline in vitro. Procedure In the first study, nine cats and eight dogs were administered doxycycline monohydrate (5 mg/kg every 12 h) and a further eight dogs were administered tetracycline hydrochloride (20 mg/kg every 8 h) for 72 h. Blood was collected at 2 and 4 h, and urine at 4 h, after the last dose. The concentration of each agent in serum and urine was determined by modified agar diffusion. In the second study, 45 urine samples from cats and dogs with urinary tract infections were cultured. Every bacterial isolate was tested in vitro using both Epsilometer (doxycycline and tetracycline) and disc diffusion (doxycycline, tetracycline or amoxycillin‐clavulanate) tests. Results Serum doxycycline concentrations in sera of cats and dogs at 2 h were 4.2±1.0 mg/mL and 3.4±1.1 mg/mL, respectively. The corresponding concentrations at 4 h were 3.5±0.7 mg/mL and 2.8±0.6 mg/mL. Urinary doxycycline concentrations at 4 h (53.8±24.4 mg/mL for cats and 52.4±24.1 mg/mL for dogs) were substantially higher than corresponding serum values. Serum tetracycline concentrations in dogs at 2 and 4 h, and in urine at 4 h, were 6.8±2.8, 5.4±0.8, 144.8±39.4 mg/mL, respectively. Most of the urinary tract pathogens (35/45) were susceptible to urinary concentrations of doxycycline and 38/45 were susceptible to tetracycline. In contrast 41/45 of all isolates were susceptible to amoxycillin‐clavulanate. Conclusion This is the first report of urinary concentrations of doxycycline after conventional oral administration. Concentrations attained in the urine of normal cats and dogs were sufficient to inhibit the growth of a significant number of urinary tract pathogens and thus doxycycline may be a useful antimicrobial agent for some urinary tract infections.

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Serum kinetics of doxycycline polyphosphate in dogs

Cited by 14 publications

References 12 publications

Pharmacokinetics of doxycycline in broiler chickens

Pharmacokinetics of doxycycline in broiler chickens

Comparative pharmacokinetics of doxycycline in cats and dogs

Susceptibility of bacteria from feline and canine urinary tract infections to doxycycline and tetracycline concentrations attained in urine four hours after oral dosage

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