Serum KIAA1199 is an advanced-stage prognostic biomarker and metastatic oncogene in cholangiocarcinoma

Zhai, Xiangyu; Wang, Wei; Ma, Yunlong; Zeng, Yijia; Dou, Deqiang; Fan, Haoning; Song, Jianping; Yu, Xin; Xin, Danqing; Du, Gang; Jiang, Zhengchen; Zhang, Hao; Zhang, Xinlu; Jin, Bin

doi:10.18632/aging.103964

Cited by 14 publications

(22 citation statements)

References 34 publications

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“…Radical tumor resection and liver transplantation are the most effective treatment options. However, owing to the difficulty of early detection, patients with HCC often lose the opportunity for surgical treatment due to local invasion and distant metastasis ( 3 ). Therefore, it is necessary to identify highly sensitive and specific diagnostic biomarkers to aid the early detection and prognostic prediction of patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of microfibrillar‑associated protein 2 is closely associated with tumor angiogenesis and poor prognosis in hepatocellular carcinoma

2021

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Abnormal expression of microfibrillar-associated protein 2 (MFAP2), a key regulator of cellular differentiation, affects the occurrence and progression of tumors. However, the underlying role of MAFP2 in hepatocellular carcinoma (HCC) remains unclear. In the present study, patterns of MFAP2 expression in HCC were analyzed using sequencing data from The Cancer Genome Atlas database. Expression profiles of MFAP2, as well as those of epithelial-mesenchymal transition (EMT)-related proteins, were compared between HCC pathological sections and fresh tissues. Thereafter, associations between patterns of MFAP2 expression and the clinicopathological characteristics of patients, and identified risk factors associated with disease-free survival (DFS) and overall survival (OS), were determined. The functions of MFAP2 in the EMT-induced proliferation and migration of MHCC97H cells were investigated using in vitro experiments, and the effects of MFAP2 on vascular endothelial growth factor A (VEGFA)-induced tumor angiogenesis were also investigated. Upregulation of MFAP2 expression was observed in HCC, and was often accompanied by the abnormal expression of EMT-related marker proteins. In addition, analysis of clinical data from 94 patients with tumor tissues revealed a significant positive correlation between MFAP2 expression and low DFS and low OS following surgery. Through in vitro experimentation, silencing MFAP2 expression was shown inhibit EMT, which thereby inhibited cellular proliferation and migration. Moreover, downregulation of MFAP2 inhibited tumor angiogenesis via the inhibition of VEGFA. Taken together, these findings indicate that MFAP2 has the potential to predict the prognosis of patients with HCC. MFAP2 also induces tumor cell proliferation and migration through EMT, and promotes tumor blood vessel formation through VEGFA, suggesting that MFAP2 may be a potential therapeutic target for HCC.

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Section: Introductionmentioning

confidence: 99%

Upregulation of microfibrillar‑associated protein 2 is closely associated with tumor angiogenesis and poor prognosis in hepatocellular carcinoma

2021

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“…Here, we attempted to elucidate the role of KIAA1199 in tumorigenesis of EOC in our present study. It is reported that KIAA1199, a transmembrane protein, expressed in various types of malignant tumor (Liu et al, 2018;Tang et al, 2018;Wang et al, 2020;Zhai et al, 2020;Zhao et al, 2019). Some research data presented that KIAA1199 gene was highly expressed in malignant tumors and could play a major role in cell mortality of normal human cells, thus combating cell immortality and tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

KIAA1199 induces advanced biological behavior and development of ovarian cancer through activation of the IL-6/STAT3 pathway

Gu¹,

Qin²,

Gao³

et al. 2022

Biocell

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Section: Discussionmentioning

confidence: 99%

“…To date, BC has been the most frequently diagnosed malignancy worldwide and leads to 684,996 deaths ( Rodrigues et al, 2019 ; Zhai et al, 2020 ). Although the prognosis of cancer patients has improved dramatically with the advanced medical technology ( Rodrigues et al, 2019 ; Zhai et al, 2020 ), a complete cure for BC patients is not yet possible with the currently available therapies due to the ambiguous mechanism of tumorigenesis and tumor progression in BC. Accumulated evidence shows that the over-expression of CEMIP could enhance proliferation, adhesion, motility, invasiveness, and EMT of various carcinomas, including BC, as well as its transcriptional regulation mechanism in many cancers ( Liu et al, 2021a ), indicating that CEMIP might play an important role in BC.…”

Section: Discussionmentioning

confidence: 99%

“…CEMIP is a kind of secreted protein, identified as an inner ear-specific protein at first, and mutations in it are related to non-syndromic hearing loss. In the past decades, an increasing number of studies have revealed that high expression of CEMIP promotes numerous malignancy progresses and metastasis and predicts poor prognosis of cancer patients, including breast ( Jami et al, 2014 ), colorectal ( Fink et al, 2015 ), liver, gastric, pancreatic, lung ( Li et al, 2020a ), prostate, cholangitis ( Zhai et al, 2020 ), ovarian ( Shen et al, 2019 ), and papillary thyroid cancers ( Liu et al, 2021a ). On the other hand, accumulated cell- and animal-based evidence shows that the over-expression of CEMIP could enhance proliferation, survival ( Michishita et al, 2006 ), adhesion, motility, invasiveness, and epithelial-to-mesenchymal transition (EMT) ( Liu et al, 2021b ) of various cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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High Expression of CEMIP Correlates Poor Prognosis and the Tumur Microenvironment in Breast Cancer as a Promisingly Prognostic Biomarker

et al. 2021

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Cell migration-inducing hyaluronidase 1 (CEMIP), a Wnt-related protein and also known as KIAA1199, is implicated in the process of metastatic colonization in a variety of malignant tumors, including breast cancer (BC), which is one of the most frequently diagnosed tumors in women worldwide. In this study, multiple public databases, online analytical tools, and bioinformatics approaches were applied to explore the expression levels, regulatory mechanisms, and biological functions of CEMIP in BC. We illustrated that CEMIP was highly expressed in various kinds of carcinomas, including BC, especially advanced subtypes, and predicted less favorable prognosis (negatively associated with overall survival) in BC patients, which might be an independent prognostic factor. Then, we revealed that the mutation and high expression of CEMIP might lead to it as an oncogene. We also demonstrated that TP53 mutation, DNA hypo-methylation, and the expression changes of three potential upstream transcription factors (EZH2, EGR1, and JUN) of CEMIP were likely to cause the hyperexpression of CEMIP in BC. Moreover, our findings suggested that CEMIP might exert its carcinogenic roles in the tumor microenvironment via participation in the extracellular matrix formation, increasing cancer-associated fibroblast (CAF), M2 macrophage, and neutrophil infiltration and decreasing CD8+ T cell infiltration. In summary, our study provided more solid evidence for CEMIP as a prognostic and metastatic biomarker and a potential therapeutic target in BC. Of course, these findings also need more confirmations of basic experiments and further clinical trials in the future.

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Serum KIAA1199 is an advanced-stage prognostic biomarker and metastatic oncogene in cholangiocarcinoma

Cited by 14 publications

References 34 publications

Upregulation of microfibrillar‑associated protein 2 is closely associated with tumor angiogenesis and poor prognosis in hepatocellular carcinoma

Upregulation of microfibrillar‑associated protein 2 is closely associated with tumor angiogenesis and poor prognosis in hepatocellular carcinoma

KIAA1199 induces advanced biological behavior and development of ovarian cancer through activation of the IL-6/STAT3 pathway

High Expression of CEMIP Correlates Poor Prognosis and the Tumur Microenvironment in Breast Cancer as a Promisingly Prognostic Biomarker

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