Serum iron parameters in liver cirrhosis

Siregar, Gontar Alamsyah; Maail, W.

doi:10.1088/1755-1315/125/1/012217

Cited by 2 publications

(8 citation statements)

References 10 publications

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“…The results of the present study confirm those of Siregar and Maail (2018) who found an increase in hepatic iron accumulation and iron related serum markers elevation. In the current study, the reduction in serum TIBC may be one of the causative factors of serum iron loading.…”

Section: Discussionsupporting

confidence: 92%

“…Such decrease can leave ionized iron to be available for excessive production of free radicals with subsequent formation of oxidative stress, DNA modification and initiation of hepatocarcinogenesis. (Siregar and Maail, 2018;Shibutani et al, 1991). Therefore, one can suggest that iron loading and oxidative stress can also participate in reduction of hepcidin as was reported by Castagna et al (2010) who also suggested that HCV infection in animal and in cellular models may directly modulate hepcidin expression via HCV-induced reactive oxygen species (ROS).…”

Section: Discussionmentioning

confidence: 87%

“…The results of the present study confirm their findings in that the mean ferritin levels were increased in sera of patients with HCC than those of non-HCC. In 2015, Sekine et al (2014) reported that HCV core protein up-regulates iron uptake into the mitochondria, and thus, exacerbates oxidative stress (lipid peroxidation and reduction in GSH and NADPH concentrations) as well as hepatic toxicity (Siregar and Maail, 2018). Since our patients are chronically infected with HCV, one can expect the incorporation of viral proteins as well as viral RNA in iron loading, oxidative stress and hepatic toxicity; including HCC.…”

Section: Discussionmentioning

confidence: 91%

“…Also, Siregar and Maail (2018) showed that ferritin levels were increased with the progression of Child-Pugh class (p<0.001), i.e. with the increase in the severity of liver disease.…”

Section: Discussionmentioning

confidence: 94%

“…This reaction produces hydroxyl radicals which initiate other radical reactions that will ultimately damage the liver cells (Khare and Garg, 2015). In this regard, Siregar and Maail, (Siregar and Maail, 2018) argue the increase in oxidative stress for the increment in iron loading in their patients. These increases strongly favor DNA damage, genetic instability, and tumorigenesis which are already the case in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Can Serum Iron Parameters Represent Surrogate Markers for Chronic Hepatitis C-Based Hepatocellular Carcinoma?

Latif

Shiha

Samir

et al. 2018

African Journal of Biological Sciences

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Iron homeostasis is of critical for human life. The pathogenesis of its accumulation in chronic hepatitis C (CHC) virus is not yet completely understood. Objectives: The aim is to investigate the possible correlations between serum metabolic markers of iron, HCV viral load, total micro-RNA-cDNA and the progression of liver disease into hepatocellular carcinoma (HCC). Patients and methods, A total of 126 patients with chronic hepatitis C virus were included in this study. Of them 22 patients were with HCC and 44 were CHC patients without HCC. In addition, a group of 30 healthy individuals were included and was served as control group. RNA was extracted and total microRNA was converted into-cDNA and was determined by nanoQuant, iron status with standard assay techniques. HCV antibodies were evaluated by enzyme linked immunosorbent assay (ELISA) and HCV-RNA by real time polymerase chain reaction (RT-PCR). Alpha-fetoprotein, routine liver function tests, international normalization ratio (INR) and platelets count were also done. Beside, HCV-related HCC were radiologically proved via abdominal US and Triphasic abdominal CT. Results: Markers of iron metabolism; including iron and ferritin were dramatically increased in sera of HCC patients compared with those of the non-HCC group. Conversely, the mean TIBC level was highly reduced in sera of HCC patients , group compared with that of the non-HCC individuals. Significant and positive correlations were found between the individual levels of iron markers with serum liver enzymes and bilirubin. On the other hand, negative correlations were found between the levels of these markers with both albumin and platelets, especially in the blood of HCC patients. Total miRNA-cDNA and viral RNA showed no significant difference among the two groups but the level of the former was significantly lowered in sera of HCC patients compared with those of the control group. In conclusion, these results suggest that serum markers of iron mediate liver disorders; especially HCC and can represent surrogate markers for the severity of such disorders. Also, the role viral molecules and/or micro-RNA in iron overload must not be neglected.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 91%

“…Also, Siregar and Maail (2018) showed that ferritin levels were increased with the progression of Child-Pugh class (p<0.001), i.e. with the increase in the severity of liver disease.…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Can Serum Iron Parameters Represent Surrogate Markers for Chronic Hepatitis C-Based Hepatocellular Carcinoma?

Latif

Shiha

Samir

et al. 2018

African Journal of Biological Sciences

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Cutoff Values for Serum Ferritin in"&#".ord($0).";""&#".ord($0).";"Predicting Cirrhosis Severity due to Cholestatic Jaundice in Vietnamese Children

Thieu¹,

Minh²,

Tuong³

et al. 2022

Med Arch

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Background: High serum ferritin levels are associated with liver cirrhosis severity and worse outcomes for hepatopathies. This study determined the serum ferritin cutoff values for predicting cirrhosis severity in children with cholestatic jaundice. Methods: A retrospective study was performed, including all cases diagnosed with cirrhosis in children aged 1 month to 16 years at Children’s Hospital 2-Vietnam between 2016 and 2021. Receiver operating characteristic (ROC) curve analysis was used to estimate ferritin cutoff values for predicting disease severity. Results: The study included 95 patients with cirrhosis due to cholestatic jaundice. Decompensated cirrhosis accounted for the majority (74.7%) of cases. Increased serum ferritin concentrations predicted cirrhosis severity in children, and the optimal ferritin cutoff value for predicting decompensated cirrhosis was determined to be 195 μg/l, resulting in a sensitivity of 65.22%, a specificity of 95.83%, and an area under the ROC curve (AUC) or 0.82. The Child–Pugh C group had higher ferritin levels than the Child–Pugh A and B group (p < 0.001), and the ferritin cutoff value for distinguishing between Child–Pugh classifications was 195 μg/l, resulting in a sensitivity of 71.2%, a specificity of 87.9%, and an AUC of 0.80. Conclusions: Serum ferritin levels are significantly associated with decompensated cirrhosis and disease severity (as assessed by Child–Pugh score). Routine serum ferritin testing may contribute to predicting cirrhosis severity in children.

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Serum iron parameters in liver cirrhosis

Cited by 2 publications

References 10 publications

Can Serum Iron Parameters Represent Surrogate Markers for Chronic Hepatitis C-Based Hepatocellular Carcinoma?

Can Serum Iron Parameters Represent Surrogate Markers for Chronic Hepatitis C-Based Hepatocellular Carcinoma?

Cutoff Values for Serum Ferritin in"&#".ord($0).";""&#".ord($0).";"Predicting Cirrhosis Severity due to Cholestatic Jaundice in Vietnamese Children

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