Serum iron levels are an independent predictor of in-hospital mortality of critically ill patients: a retrospective, single-institution study

Xia, Jian‐Jun; Wang, Fei; Jiang, Xiaonan; Jiang, Tingting; Shen, Li; Liu, Yue; You, Da-Li; Ding, Yong; Ju, Xuefeng; Wang, Li; Xiao, Wu; Hu, Shan‐You

doi:10.1177/0300060518795528

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…Iron deficiency was highly prevalent in idiopathic pulmonary arterial hypertension, and the extent of iron deficiency was also related to hemodynamics [10]. The level of serum iron was thought to be an independent predictor of in-hospital mortality in critically ill patients [11]. We noted that patients with COVID-19 who died during hospitalization had markedly severe chest CT images and significantly lower serum iron levels compared with those who survived before and after treatment.…”

Section: Discussionmentioning

confidence: 90%

Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study

Zhao

Huang

Dai

et al. 2020

Open Forum Infectious Diseases

126

128

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Abstract Background Various types of pulmonary diseases are associated with iron deficiency. However, information on iron status in coronavirus disease 2019 (COVID-19) is scarce. Methods This study included 50 hospitalized patients with confirmed COVID-19. The role of serum iron in predicting severity and mortality of COVID-19 was evaluated. Results The most common symptoms of COVID-19 patients in this study were cough (82%), fever (64%), and chest distress (42%). Of the 50 patients, 45 (90%) patients had abnormally low serum iron levels (<7.8 μmol/L). The severity of COVID-19 was negatively correlated with serum iron levels before and after treatment and was positively correlated with C-reactive protein, serum amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels. Decreased serum iron level could predict the transition of COVID-19 from mild to severe and critical illness. Seven (53.8%) patients with a lower serum iron level after treatment in the critical group had died. There was a significant difference in posttreatment serum iron levels between COVID-19 survivors and nonsurvivors. Conclusions Serum iron deficiency was detected in the patients with COVID-19. The severity and mortality of the disease was closely correlated with serum iron levels. Low serum iron concentration was an independent risk factor for death in COVID-19 patients.

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Section: Discussionmentioning

confidence: 90%

Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study

Zhao

Huang

Dai

et al. 2020

Open Forum Infectious Diseases

126

128

View full text Add to dashboard Cite

show abstract

“…However, the renal function was normal in this study, which was inconsistent with that in a previous study. It has been reported that a decreased level of serum iron in patients with pneumonia is an independent risk factor for in-hospital death [17] . The mechanism may be related to the influence of pathogenic microorganism infection on iron uptake.…”

Section: Discussionmentioning

confidence: 99%

Acute myelitis after SARS-CoV-2 infection: a case report

Zhao

Huang

Dai

et al. 2020

Preprint

197

198

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We report a case of acute myelitis in a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A 66-year-old man with coronavirus disease 2019 was admitted with acute flaccid paralysis of the bilateral lower limbs and urinary and bowel incontinence. All serum microbiological test results were negative, except for SARS-CoV-2 nucleic acid testing.Clinical findings indicated post-infectious acute myelitis. He received treatment containing ganciclovir, lopinavir/ritonavir, moxifloxacin, dexamethasone, human immunoglobulin, and mecobalamin. With a diagnosis of post-infectious acute myelitis and comprehensive treatment, paralysis of the bilateral lower extremities ameliorated. After two negative novel coronavirus RNA nasopharyngeal swab tests, he was discharged and transferred to a designated hospital for isolation and rehabilitation therapy.

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“…Also, iron deficiency can affect immune system function and hypoxia sensing. Little is known about the potential role of disturbing iron homeostasis in COVID-19 [ 34 , 35 ]. An investigation on 50 COVID-19 patients has indicated most of them had extremely low levels of serum iron, which was defined as a predictor of mortality [ 34 ].…”

Section: The Role Of Hepcidin In Severity and Mortality Of Covid-19mentioning

confidence: 99%

The beneficial role of Hepcidin peptide inhibitor in improved the symptoms of COVID-19 in diabetics: anti-inflammatory and potential therapeutic effects

Zeinivand

jamali-Raeufy

Zavvari

2022

J Diabetes Metab Disord

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Coronavirus Disease 2019 (COVID-19) is a recent public health issue worldwide. Also, diabetes is a frequent condition with high mortality. There is a strong relationship between COVID-19 and diabetes. This article analyses the intricate relationship between COVID-19 and hepcidin. Hepcidin increases in aged non-insulin diabetic patients. Hepcidin is the last target treatment of several medications commonly used. Viral diseases, especially SARS-CoV19, can activate the hepcidin pathway leading to an elevation in the iron load. This increased iron is released into the bloodstream and results in cell death through ferroptosis, like free iron. Excess iron has pro-coagulative and toxic effects. Hepcidin overexpression and iron overload are associated with COVID-19 infection and can be considered potential targets for treatment. Several studies have shown dalteparin (anti-Hepcidin) could improve the symptoms of COVID-19 in diabetics by appropriately modulating and decreasing oxidative stress and inflammation. This finding can be leading to enhancing the existing knowledge about Therapeutic measures for reducing Covid-19 impairments in diabetics and is suggested as a possible therapeutic agent in diabetes.

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Serum iron levels are an independent predictor of in-hospital mortality of critically ill patients: a retrospective, single-institution study

Cited by 10 publications

References 23 publications

Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study

Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity and Mortality: A Retrospective Study

Acute myelitis after SARS-CoV-2 infection: a case report

The beneficial role of Hepcidin peptide inhibitor in improved the symptoms of COVID-19 in diabetics: anti-inflammatory and potential therapeutic effects

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