2019
DOI: 10.3390/medicina55050180
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Serum Iron Levels and Copper-to-Zinc Ratio in Sickle Cell Disease

Abstract: Background and Objectives: Altered copper and zinc homeostasis may influence the antioxidant defense system and consequently lead to oxidative stress and associated complications in sickle cell disease (SCD) patients. Iron levels have been reported to increase in sickle cell patients due to frequent blood transfusion, chronic intravenous haemolysis and increased absorption of iron from the gastrointestinal tract. These elevated levels of iron may also lead to extensive oxidative damage. The current study evalu… Show more

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Cited by 9 publications
(15 citation statements)
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References 26 publications
(38 reference statements)
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“…In agreement with previous reports on pediatric cohorts, 41 , 42 , 43 this study demonstrated that adults with SCD had deficiencies of zinc and vitamins B12 and D that contributed to the severity of SCD. Vitamin D deficiency is highly prevalent in Saudi Arabia due to decreased sun exposure because of the hot climate and traditional wear, covering the entire body.…”
Section: Discussionsupporting
confidence: 93%
“…In agreement with previous reports on pediatric cohorts, 41 , 42 , 43 this study demonstrated that adults with SCD had deficiencies of zinc and vitamins B12 and D that contributed to the severity of SCD. Vitamin D deficiency is highly prevalent in Saudi Arabia due to decreased sun exposure because of the hot climate and traditional wear, covering the entire body.…”
Section: Discussionsupporting
confidence: 93%
“…The second most common group of studies identi ed involved assessment of biomarkers from serum samples for macronutrients or micronutrients. Most studies were conducted in Nigeria (21/31, 68%); other studies took place in DRC [53], Tanzania [27,54,55], Egypt [56], Kenya [38], Ghana [57], Uganda [58], and Malawi [59]. Nutritional parameters measured included proteins/amino acids, fatty acids, vitamins, and minerals.…”
Section: Resultsmentioning
confidence: 99%
“…Selected minerals were evaluated in eight small studies of SCD patients and compared to healthy controls. Serum iron concentration was reduced in patients compared to controls in all studies that evaluated it [57,[69][70][71]. Serum or plasma zinc was also generally reduced in SCD patients [53,7,[70][71][72][73][74], although zinc was elevated in one population of 59 Nigerian adult SCD patients.…”
Section: Resultsmentioning
confidence: 99%
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“…However, copper could act as a prooxidant and promotes free radicals when it presents in high concentration in the state of impaired zinc bioavailability, a condition that has been previously described in various diseases, including SCD. 8,9,12,13 Also, magnesium has a role in the modulation of endothelial inflammation, besides its roles in regulating heart rhythm, immune system functions, and bone metabolism. 14 Several studies provided data on the status of these micronutrients in SCD but these data require further summary and analyses for better accuracy.…”
Section: Introductionmentioning
confidence: 99%