Serum iron concentration and plasma oxidant-antioxidant balance in patients with chronic venous insufficency

Abstract

SummaryBackgroundThe aim of this study was to evaluate serum iron concentration and influence of this element on biomarkers of oxidative stress in patients affected by chronic venous insufficiency (CVI).Material/MethodsSerum iron (SI) concentration and plasma parameters of oxidant–antioxidant balance (i.e., malonyldialdehyde [MDA], uric acid [UA] concentration, and total antioxidant capacity [TAC]) were compared between 35 patients divided into appropriate groups and 23 healthy individuals.ResultsThe subgroups analysis showed that SI concentration was significantly higher only in patients with shorter duration of CVI in comparison with the control group (P=0.013). Significant, negative correlation was found between SI concentration and duration of the disease (r=−0.422, P=0.014), age of the patients (r=−0.542, P=0.001) and BMI (r=−0.408, P=0.018). Mean value of MDA concentration and TAC capacity were higher in patients with CVI in comparison with healthy individuals (P<0.05). UA concentration was decreased, especially in CVI patients with mild clinical stage of disease and shorter CVI duration (P=0.047; P=0.034). There was no significant correlation found between SI concentration and the parameters of oxidant–antioxidant balance.ConclusionsHigh concentration of MDA and low UA level in blood of CVI patients suggests that oxidative stress plays an important role in the pathogenesis of the disease. The increase in SI concentration observed in the early stage of CVI can enhance free radicals formation; however, direct evidence has not been provided by the present study.

Antioxidative mechanism in the course of varicose veins

“…High iron concentration participates in Fenton reaction, which results in the release of highly reactive hydroxyl radical. 18 Previous study revealed an increased serum iron concentration in the initial stage of the CVI. 18 Ercan et al investigated the changes in the concentration of micronutrients, such as zinc, copper and iron, as factors that predispose to the formation of VVs.…”

“…18 Previous study revealed an increased serum iron concentration in the initial stage of the CVI. 18 Ercan et al investigated the changes in the concentration of micronutrients, such as zinc, copper and iron, as factors that predispose to the formation of VVs. However, he did not find any significant difference in the iron concentration.…”

“…9 In the light of the world literature, oxidative stress is examined primarily by measuring the concentration of malondialdehyde (MDA), estimating the degree of lipid peroxidation. 2,[17][18][19][20] All the reports have shown elevated levels of MDA in the VV wall and in the plasma of patients with VV. 2,[17][18][19][20] In this study, we determined the activity of SOD, the most powerful enzymatic antioxidant, the concentration of TAS, that determines the body ability to defend against the damaging effects of ROS and the concentration of GSH, endogenous non-enzymatic antioxidant.…”

Prophylactic treatment with transdermal deferoxamine mitigates radiation-induced skin fibrosis

“…Iron plays a critical role in catalyzing the formation of ROS via the Haber–Weiss and Fenton reactions, which result in oxidative stress 21 – 23 and cellular apoptosis 24 – 26 . Interestingly, patients with chronic wounds have also been found to have higher concentrations of iron in blood, wound tissue, and wound exudates 27 – 29 . As such, there have been multiple investigations into the therapeutic effects of iron chelators and wound healing.…”

HFE p.C282Y gene variant is associated with varicose veins in Russian population

“…Iron ions may be important independent source of ROS production. The increase in serum iron concentration has been shown in chronic venous insufficiency patients in comparison with healthy controls [44][45][46]. There is epidemiologic evidence of a relationship between the level of iron and cardiovascular diseases [47][48][49].…”