Serum Iron and Serum Bilirubin After Administration of Gd-DTPA-Dimeglumine A Pharmacologic Study in Healthy Volunteers

Niendorf, H.P.; SEIFERT, W.

doi:10.1097/00004424-198809000-00062

Cited by 11 publications

(9 citation statements)

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“…In a phase I clinical study, the administration of 0.25 mmol/kg of a non‐formulated Gd‐DTPA solution induced a transient increase in serum iron, the maximum of which occurred 6–12 h post‐injection [50,51]. The subsequent optimization of the formula with the addition of 1.0 mmol/L of free DTPA normalized the serum levels of iron [50,51]. The mechanism underlying such an increase in serum iron remains unclear.…”

Section: In Vivo Transmetallation With Body Cationsmentioning

confidence: 99%

“…The latter complex would release iron that would bind to transferrin. An alternative hypothesis could be the induction by Gd‐DTPA of haemolysis during venipuncture [51] because haemolysis leads to the saturation of transferrin and to an increase in free serum iron. However, the diagnosis of haemolysis was not supported by the release of intra‐erythrocyte enzymes (glutamate oxaloacetate transaminase, lactate dehydrogenase or α ‐hydroxybutyrate dehydrogenase) or decrease of haptoglobin [51].…”

Section: In Vivo Transmetallation With Body Cationsmentioning

confidence: 99%

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Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: a review

Idée

Port

Raynal

et al. 2006

Fundamemntal Clinical Pharma

363

269

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Gadolinium-based contrast agents (CAs) are widely used to enhance the contrast of images in magnetic resonance imaging procedures. Two categories of gadolinium chelates exist: the macrocyclic molecules where Gd3+ is caged in the pre-organized cavity of the ligand and the linear molecules. Gadolinium chelates differ in their thermodynamic stability constants and in their kinetic stability. In general, macrocyclic chelates such as Gd-DOTA or Gd-HP-DO3A are more stable than linear molecules. Even among linear agents, differences can be found. There is increasing evidence that transmetallation can be found in vivo, in the case of certain CAs (especially linear chelates), with body cations such as zinc, calcium or iron. Furthermore, analytical interference with colorimetric determination of calcium has been clinically evidenced with two linear chelates, Gd-DTPA-BMA and Gd-DTPA-BMEA. Clinical cases of spurious hypocalcaemia have been reported with these molecules. Such interference with some colorimetric assays for calcium is clinically relevant in that it can lead to unnecessary and potentially harmful treatment for hypocalcaemia.

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Section: In Vivo Transmetallation With Body Cationsmentioning

confidence: 99%

Section: In Vivo Transmetallation With Body Cationsmentioning

confidence: 99%

Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: a review

Idée

Port

Raynal

et al. 2006

Fundamemntal Clinical Pharma

363

269

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“…Thus, the water-filling method may be appropriate for MR imaging of AGC. Some investigators have insisted that the visualization of the low-signal-intensity band occurring on out-ofphase gradient-echo images is helpful in extraserosal evaluation of AGC [13]. The low-signal-intensity band occurs as a result of a chemical shift misregistration artifact and a phase cancellation artifact between fat and water [20].…”

Section: Discussionmentioning

confidence: 99%

“…Among the different oral contrast agents, a diluted aqueous solution of gadopentetate dimeglumine (Gd-DTPA) is well known as a safe and effective gastrointestinal contrast agent [4,13]. However, to our knowledge, the practical usefulness of oral contrast agent in MR imaging of gastric cancer has not been reported.…”

mentioning

confidence: 99%

MR imaging of advanced gastric cancer: comparison of various MR pulse sequences using water and gadopentetate dimeglumine as oral contrast agents

et al. 2000

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“…A small number of patients (n = 5) were examined using gadopentetate dimeglumine at doses greater than 0.1 mmol/kg [12]. However, the utility of doses greater than 0.1 mmol/kg was not extensively investigated, in part due to safety concerns related to transient, dose-related increases in serum iron and serum bilirubin levels [13,14].…”

Section: Standard Dose Applicationsmentioning

confidence: 99%

Indication-related dosing for magnetic resonance contrast media

1997

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This presentation reviews the issue of contrast media dosing and imaging protocols for the optimal MR imaging detection and characterization of pathology. The cumulative clinical experience gained in performing contrast-enhanced MR examinations with gadolinium chelates indicates that a dose of 0.1 mmol/kg body weight provides safe and effective enhancement of most CNS pathology. Doses lower than 0.1 mmol/kg have been shown to be inadequate for delineating all but selected types of CNS pathology, such as masses with a high lesion to background ratio on post-contrast images (acoustic neuromas) or lesions located in areas in which the normal tissue very rapidly takes up contrast agent (e. g. microadenomas in the pituitary gland). Recent clinical studies have suggested a role for high dose gadolinium administration (up to 0.3 mmol/kg) for the optimal detection and delineation of cerebral metastases or other small or poorly enhancing lesions. Differences in the histopathologic characteristics (capillary permeability, vascularity, location, size) of specific diseased tissues may require varying doses or even a different contrast agent to be used for optimal imaging results. As new MR contrast agents and new scanning techniques are introduced, the specific diagnostic question posed will likely determine the choice of pulse sequence, contrast agent and dose used.

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Serum Iron and Serum Bilirubin After Administration of Gd-DTPA-Dimeglumine A Pharmacologic Study in Healthy Volunteers

Cited by 11 publications

References 0 publications

Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: a review

Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: a review

MR imaging of advanced gastric cancer: comparison of various MR pulse sequences using water and gadopentetate dimeglumine as oral contrast agents

Indication-related dosing for magnetic resonance contrast media

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