Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

Löffler, Dennis; Müller, Ulrike; Scheuermann, Kathrin; Friebe, Daniela; Gesing, Julia; Bielitz, Julia; Erbs, Sandra; Landgraf, Kathrin; Wagner, Isabel; Kieß, Wieland; Körner, Antje

doi:10.1210/jc.2014-2932

Cited by 162 publications

(184 citation statements)

References 37 publications

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…The level of irisin was found to be increased after acute exercise as expected, however, irisin levels were found to be decreased after chronic exercise training [12,13].…”

Section: Accepted Manuscriptsupporting

confidence: 67%

Irisin levels in the progression of diabetes in sedentary women

Duran

Gülçelik

Ünal

et al. 2015

Clinical Biochemistry

View full text Add to dashboard Cite

“…The level of irisin was found to be increased after acute exercise as expected, however, irisin levels were found to be decreased after chronic exercise training [12,13].…”

Section: Accepted Manuscriptsupporting

confidence: 67%

Irisin levels in the progression of diabetes in sedentary women

Duran

Gülçelik

Ünal

et al. 2015

Clinical Biochemistry

View full text Add to dashboard Cite

“…Also, the browning formation that Irisin may cause could lead to reduced weight gain, up-regulated insulin sensitivity, reduced risk of diabetes type II and other metabolic disorders as animal studies indicate [89][90][91][92][93] , as well as increase daily resting energy expenditure in humans 94,95 . However, the secondary outcomes of our systematic review shows that even when Irisin was measured with the same ELISA (PP, EK-067-52) there was no relationship 22 or a positive relationship with resting energy expenditure 37 , and no association 72 or a positive association with BMI 71 . This specific ELISA kit (PP, EK-067-52) has been tested by a previous study for validity 27 , which showed it to be invalid for circulating Irisin identification.…”

Section: Quality Of Evidence and Limitationsmentioning

confidence: 76%

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

et al. 2017

View full text Add to dashboard Cite

Exercise may activate a brown adipose-like phenotype in white Background: adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and fibronectin type III domain-containing protein 5 (FNDC5) in muscle, circulating Irisin and uncoupling protein one (UCP1) of white adipocytes in humans. Two Methods: databases (PubMed 1966 to 08/2016 and EMBASE 1974 to 08/2016 were searched using an appropriate algorithm. We included articles that examined physical activity and/or exercise in humans that met the following criteria: a) PGC-1a in conjunction with FNDC5 measurements, and b) FNDC5 and/or circulating Irisin and/or UCP1 levels in white adipocytes. We included Results: 51 studies (12 randomised controlled trials) with 2474 participants. Out of the 51 studies, 16 examined PGC-1a and FNDC5 in response to exercise, and only four found increases in both PGC-1a and FNDC5 mRNA and one showed increased FNDC5 mRNA. In total, 22 out of 45 studies that examined circulating Irisin in response to exercise showed increased concentrations when ELISA techniques were used; two studies also revealed increased Irisin levels measured via mass spectrometry. Three studies showed a positive association of circulating Irisin with physical activity levels. One study found no exercise effects on UCP1 mRNA in white adipocytes.The Conclusions: effects of physical activity on the link between PGC-1a, FNDC5 mRNA in muscle and UCP1 in white human adipocytes has attracted little scientific attention. Current methods for Irisin identification lack precision and, therefore, the existing evidence does not allow for conclusions to be made regarding Irisin responses to physical activity. We found a contrast between standardised review methods and accuracy of the measurements used. This should be considered in future systematic reviews.

show abstract

“…The 24-h serum profiles of the bone markers and levels after a bout of acute strenuous exercise [21] were assessed in 4 young adults with no reported chronic disease (2 lean individuals [BMI 20.5–21.2] aged 20 and 21 years and 2 obese individuals [BMI 35.5 and 35.7] aged 32 and 34 years.…”

Section: Methodsmentioning

confidence: 99%

The Bone Markers Sclerostin, Osteoprotegerin, and Bone-Specific Alkaline Phosphatase Are Related to Insulin Resistance in Children and Adolescents, Independent of Their Association with Growth and Obesity

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background/Aims: Sclerostin, osteoprotegerin, and bone-specific alkaline phosphatase (B-ALP), which are primarily related to bone metabolism, have been linked with insulin resistance in adults. We aimed to evaluate the association of these markers with growth, obesity, and parameters of insulin resistance in lean and obese children and adolescents. Methods: We measured sclerostin, osteoprotegerin, and B-ALP in fasting and oral glucose tolerance test (oGTT) serum samples from 1,325 children and adolescents, and during 24-h profiles and after exercise and glucose exposure in young adults. Results: In addition to the positive relationship with height standard deviation scores (SDS), sclerostin (r = 0.035, p < 0.001) and B-ALP (r = 0.06, p = 0.028) increased, whereas osteoprotegerin (r = –0.098, p < 0.001) decreased with BMI SDS. Furthermore, B-ALP correlated with fasting- and oGTT-derived markers of glucose and insulin metabolism suggestive of insulin resistance. To evaluate potential confounding diurnal variation of bone markers, we performed 24-h profiles. B-ALP and osteoprotegerin had lower night-time levels. Exercise acutely and transiently increased B-ALP and osteoprotegerin levels, but glucose ingestion had no effect. Conclusions: Besides their association with growth, sclerostin and osteoprotegerin levels are altered in childhood obesity. Particularly B-ALP was related to insulin resistance indices. Our findings accent the link between bone, growth, and insulin resistance.

show abstract

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

Cited by 162 publications

References 37 publications

Irisin levels in the progression of diabetes in sedentary women

Irisin levels in the progression of diabetes in sedentary women

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

The Bone Markers Sclerostin, Osteoprotegerin, and Bone-Specific Alkaline Phosphatase Are Related to Insulin Resistance in Children and Adolescents, Independent of Their Association with Growth and Obesity

Contact Info

Product

Resources

About