Serum intracellular adhesion molecule-1 and interleukin-8 as predictors of pulmonary impairment among workers in secondary copper smelters

Fouad, Mohamed; Ramadan, Mona

doi:10.1007/s00420-021-01770-3

Cited by 1 publication

(1 citation statement)

References 40 publications

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“…A relevant result was also obtained for IL-8 levels, which were highly increased not only between HCs and patients but also between patients with SS and the group with a more advanced stage of the disease, PMF, which means that this cytokine, along with others, could be a good candidate marker to discriminate between disease stages. This is in line with recently published data where IL-8 levels were associated with progression and death in silicosis [ 15 ], with pulmonary impairment in copper smelter workers [ 34 ] and with progression in CWP disease [ 35 ]; however, in another study with CWP patients, no significant differences were observed in IL-8 levels [ 36 ].…”

Section: Discussionsupporting

confidence: 91%

Plasma Cytokine Profiling Reveals Differences between Silicotic Patients with Simple Silicosis and Those with Progressive Massive Fibrosis Caused by Engineered Stone

Campos‐Caro

Jiménez-Gómez

García-Núñez

et al. 2023

IJMS

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Engineered stone silicosis has become an occupational epidemic disease that progresses rapidly to progressive massive fibrosis with respiratory failure and death, and there is no effective treatment. Silica deposition in the lung triggers a series of inflammatory reactions with the participation of multiple cytokines and cellular mediators whose role in the development and progression of the disease is largely unknown. We hypothesized that differences in plasma cytokine levels exist between patients diagnosed with simple silicosis (SS) and patients diagnosed with progressive massive fibrosis (PMF). Plasma samples from 91 ES silicosis patients, diagnosed and classified by chest radiography and/or high-resolution computed tomography with SS (n = 53) and PMF (n = 38), were assayed by multiplex assays for levels of 34 cytokines. Additionally, a healthy volunteer control group (n = 22) was included. Plasma levels of a high number of cytokines were significantly higher in subjects with silicosis than in healthy control subjects. Moreover, the levels of IL-1RA, IL-8, IL-10, IL-16, IL-18, TNF-α, MIP-1α, G-CSF and VEGF were significantly elevated in PMF compared to SS patients. This study shows that plasma cytokine levels differ between healthy people and silicosis patients, and some of them are also significantly elevated in patients with PMF compared with patients with SS, which could indicate their involvement in the severity of the disease, be considered as biomarkers and could be explored as future therapeutic targets for the disease.

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