Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes

Giuliani, Nicola; Sansoni, Paolo; Girasole, G.; Vescovini, Rosanna; Passeri, Giovanni; Passeri, M; Pedrazzoni, M.

doi:10.1016/s0531-5565(00)00220-5

Cited by 133 publications

(97 citation statements)

References 41 publications

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“…Together, this may indicate greater basal IL-6 bioavailability in the elderly. In contrast to these results, one study found an increase sIL-6R and s-gp130 with age up until the seventh decade in women (20). These differences may be due to the good health of our subjects and/or potential sex differences in circulating levels of these receptors.…”

Section: Discussioncontrasting

confidence: 84%

Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress

Sacheck¹,

Cannon²,

Hamada³

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

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mediates many aspects of the exercise-induced acute-phase response, including upregulation of antioxidant defenses. Moreover, IL-6 synthesis is regulated in part by oxidative stress. This investigation tested the hypothesis that an IL-6-mediated acute-phase response after exercise provides negative-feedback protection against exerciseinduced oxidative stress. Healthy young (n ϭ 16, 26.4 Ϯ 1.8 yr) and older men (n ϭ 16, 71.1 Ϯ 2.0 yr) ran downhill for 45 min at 75% maximal oxygen consumption before and after a 12-wk period of supplementation with vitamin E (1,000 IU/day) or placebo. Circulating IL-6 and soluble IL-6 receptors, peripheral mononuclear cell production of IL-6, and IL-6 transcripts in muscle were measured before and within a 72-h time window after each acute exercise bout. At all time points plasma IL-6, IL-6 bioavailability, and C-reactive protein were higher in the older men; yet in response to exercise, young and older subjects experienced similar increases in these factors. Although the magnitude of postexercise changes in acutephase variables was independent of age, correlations among plasma, mononuclear cell, and muscle IL-6 and oxidative stress were evident only in young men (R 2 ϭ 0.64, 0.35, and 0.33, respectively). These changes in circulating IL-6 were closely associated with a prooxidant state (R 2 ϭ 0.47), whereas muscle IL-6 mRNA correlated with an antioxidant state (R 2 ϭ 0.65). Supplementation with vitamin E did not affect exercise-induced responses or differences between the young and old men in a consistent manner. Therefore, oxidative stress is linked to the acute-phase response after exercise in young men, but not in older men who had elevated acute-phase reactants, suggesting that further research is warranted to determine the basis for these differences.

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Section: Discussioncontrasting

confidence: 84%

Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress

Sacheck¹,

Cannon²,

Hamada³

et al. 2006

American Journal of Physiology-Endocrinology and Metabolism

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“…Thus, the increased inflammatory reactivity such as increased serum IL-6 and cytokine levels in unstimulated PBMC supernatant among post-menopausal women may be related to lower circulating levels of reproductive hormones. In addition, serum levels of IL-6 and soluble IL-6 receptor (sIL-6R) in humans were highly detected in pathological processes of osteoporosis (Abrahamsen et al 2000;Giuliani et al 2001;Scheidt-Nave et al 2001). IL-6 is a pleiotropic cytokine which has multiple effects on different cell types (Kallen 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Also, the measurement of sIL-6R needs to be considered in further study. Circulating IL-6 combines with sIL-6R and the IL-6/sIL6R complex increases the half-life of IL-6 and allows signaling to occur in tissues devoid of membrane IL-6R, thus it may provide more information (Giuliani et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

Kim

Chae

Paik

et al. 2011

AGE

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Inappropriate interleukin-6 production is thought to play a role in the development of several age-related conditions including atherosclerosis. This study aimed to determine whether aging affects circulating interleukin-6 (IL-6) levels. Healthy, nonobese women (n = 208, 44.5 ± 0.70 years, 22.4 ± 0.17 kg/m 2 ) were categorized into four age groups (22-31, 32-41, 42-51, and 52-63 years; crosssectional study). Cytokine levels in serum and those produced from peripheral blood mononuclear cell (PBMC) were measured. The oldest group had the highest circulating levels of IL-6 and oxidized lowdensity lipoprotein (ox-LDL) and higher PBMC production of IL-6, tumor necrosis factor-α (TNF-α), and interleukin-1 alpha (IL-1β). Additionally, significant interactions between age and menopause were found for serum IL-6 (P=0.024), and TNF-α (P= 0.011) and IL-1β (P<0.001) produced from PBMCs. Serum IL-6 levels positively correlated with age, waist-hip ratio (WHR), systolic blood pressure, circulating levels of TNF-α, IL-1β, and ox-LDL, and urinary 8-epi-prostaglandin F 2 α. Multiple stepwise AGE (2012) 34:415-425

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“…In the circulation, IL-6 can combine with sIL-6R to form an IL-6/sIL-6R complex, which increases the half-life of IL-6 and allows signaling to occur in tissues devoid of membrane IL-6R, a process termed "trans-signaling" (Kallen 2002). This complex can be rendered inactive by a soluble form of the gp130 receptor (Giuliani et al 2001). Although there is an abundance of research characterizing the response of IL-6 to exercise (Colbert et al 2004;Jankord and Jemiolo 2004;Bruunsgaard 2005;Goldhammer et al 2005;Pedersen and Febbraio 2008), few studies have investigated the influence of physical activity on sIL-6R and sgp130 levels (You et al 2004;Gray et al 2009;Beavers et al 2010b).…”

Section: Discussionmentioning

confidence: 99%

Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men

Gonzalo-Calvo

Fernández‐García

Luxán-Delgado

et al. 2011

AGE

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The objective of the present study was to investigate the changes in a large panel of emergent geriatric biomarkers in long-term trained elderly men to analyze the effects of long-term exercise on an aged population. We collected blood samples from two groups of male volunteers older than 65 years who maintain a measure of functional independence: one group of sedentary subjects without a history of regular physical activity and the other of subjects who have sustained training, starting during adulthood (mean training time=49±8 years). We studied morbidity, polypharmacy, cellular and serological inflammatory parameters, and endocrine mediators. After adjusting for confounding factors, we observed reduced medication intake per subject and lower number of diseases per subject with statistical differences nearly significant in the long-term exercise group. We showed that long-term training was associated with lower levels of white blood cell counts, neutrophil counts, interleukin-6, interleukin-10, interleukin-1 receptor antagonist, and soluble TNF receptor-I. Furthermore, we noted an increase in the concentrations of insulin-like growth factor-1 and dehydroepiandrosterone in the long-term training group. We concluded that long-term exercise training from adulthood to old age is clearly associated with a healthy profile of emergent geriatric biomarkers. Long-term training could improve the inflammatoryendocrine imbalance associated with disease, frailty, functional decline, and mortality in elderly men. Our results point to the benefits of prolonged exercise from adulthood to old age.

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Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes

Cited by 133 publications

References 41 publications

Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress

Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress

Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men

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