Serum interleukin-6: Association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease

Shim, Andrey; Aksyonov, A.A.; Mitrokhin, Vadim; Lovchikova, Irina; Konoplyannikov, Mikhail; Konev, A V; Zotov, A S; Овчинников, Р. С.; Antova, Emilija; Kamkin, Andre

doi:10.1016/j.cellimm.2016.09.007

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Basically, despite the established IL-6 interaction with other inflammatory mediators in patients with CAD,15–18 evidence of any association between all studied IL-6/IL-6R genotypes and circulatory IL-6 concentration remains unconfirmed in this study.…”

Section: Resultsmentioning

confidence: 55%

Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: inﬂuence of interleukin-6/6R gene polymorphisms on inﬂammatory markers

Mitrokhin

Nikitin

Brovkina

et al. 2017

JIR

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This study determined the genotype effects of interleukin (IL)-6/IL-6R single nucleotide polymorphisms (SNPs) on circulating levels of different cytokines in healthy and coronary artery disease (CAD) patients with different allele frequencies. In the control patients, rs1800795 showed significant differences in IL-18 concentrations between CC and CG and CC and GG genotypes (P=0.003 and 0.004, respectively). Furthermore, circulatory IL-1β was significantly different between GC and GG genotypes from the same SNP (P=0.038). In the diseased patients, significance was determined only for IL-2 (P=0.021) between the C and G homozygote allele carriers of rs1800795. The diseased GC and GG genotype carriers were statistically different for IL-2 (P=0.049) from the rs1800796 and for IL-4 (P=0.049) from the rs2228044. IL-4 was also statistically significant between the GC and CC genotypes from the rs2228043 of the IL-6R gene (P=0.025). The last combination of genotypes in the same gene for the same SNP was statistically significant for IL-10 (P=0.036). According to the logistic regression, only gender (odds ratio [OR] =2.43) and triglycerides (OR =1.98) could be taken as determinants of CAD, while examined SNPs genotypes were not identified as risk factors for CAD. In general, the IL-6 polymorphism genotypes were mainly associated with inflammatory cytokines, while the IL-6R polymorphism genotypes were associated with anti-inflammatory cytokines.

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Section: Resultsmentioning

confidence: 55%

Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: inﬂuence of interleukin-6/6R gene polymorphisms on inﬂammatory markers

Mitrokhin

Nikitin

Brovkina

et al. 2017

JIR

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“…Based on a reported variety of associations between IL-18 SNPs and CAD, 11 in this study, we examined the associations between IL-18/IL-18R SNPs and circulating levels of different cytokines in the Russian population. In this direction, different epidemiologic studies have revealed that specific SNPs in the different genes such as IL-6, 13 , 16 – 18 IL-17, 19 IL-18, 20 and IL-23 are associated with the development of CAD. 21 – 27 In the present study, a significant association between the CAD GG carriers of rs1946518 and rs187238 SNPs and the higher circulating IL-8 levels was shown.…”

Section: Discussionmentioning

confidence: 99%

Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression

Mitrokhin

Nikitin

Brovkina

et al. 2018

JIR

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PurposeThe present study investigated the influence of IL-18/18R genetic variants on cytokine expression in patients with stable coronary artery disease (CAD).Materials and methodsThe polymorphisms rs1946518, rs187238, rs326, rs1169288, and rs183130 were determined in patients with and without CAD. Circulating cytokine levels were measured immunologically.ResultsThe rs1946518-GG genotype shows higher IL-18 concentration in the group with CAD, but still not significant. The TG genotype from rs1946518 in carriers with CAD showed a significant decrease in relation to the pro-inflammatory cytokines IL-6, IL-8, and IL-18. The decreases of IL-6 and IL-8 were also specific for rs187238 CAD carriers with the GC genotype. The CAD carriers with the AA genotype from rs326 in the IL-18R gene showed significant increase in IL-8 and IL-18 in comparison with those without CAD. Regarding rs1169288 from the IL-18R gene, IL-8 showed a T allele-dependent increase. In the last rs183130 polymorphism of the IL-18R gene, the pro-inflammatory onset showed a C allele-dependent disease-associated decrease in IL-8 CC and IL-6 CT carriers. In contrast, the CAD CT carriers in relation to IL-8 showed significant increase.ConclusionsMost of the IL-18/18R single-nucleotide polymorphisms were mainly associated with pro-inflammatory cytokines. It is surmised that these associations between some pro-inflammatory cytokines (mainly IL-8) and some IL-18R genotypes in the subjects with CAD from this study are most likely based on inflammatory-induced upregulation of IL-18R expression.

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“…Several inflammatory markers could stratify patients with high CV risk. Inflammation and the altered release of cytokines are the processes promoting the formation, development and rupture of atherosclerotic plaque which is the essential mechanism causing ACS [ 17 ]. IL6 is synthesized by several cell types such as hepatic fibroblasts, macrophages, and monocytes as well as fat cells, vasculature and myocardial cells [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention

Bouzidi,

Gamra

2023

BMC Cardiovasc Disord

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Background Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD). Methods Three hundred ten angiografically diagnosed CAD patients and 210 controls were enrolled in this study. CAD patients were stratified according to IL-6 cut-off value into high levels IL-6 group (≥ 9.5 pg/mL) and low levels IL-6 group (< 9.5 pg/mL). The severity of CAD was assessed according to Gensini score (GS), artery stenosis degree and the number of vessels involved. The mean age was 60.3 ± 11.0 years. Results The level of IL-6 in patients was increased compared to controls and ranged from 1.5 to 3640.0 pg/mL. High levels of IL-6 were significantly associated with high levels of GS (> 40) but not with stenosis degree and vessel score. GS levels were significantly more elevated in patients with high levels of IL-6 group than in low IL6 levels patients (60.6 ± 39.5 vs 46.7 ± 37.2; p = 0.027). The analysis of the ROC curve performed in myocardial infarction patients showed that IL-6 (AUC: 0.941 (CI 95% 0.886, 0.997; p < 0.001) could be a powerful predictor marker in evaluating the infarct size after myocardial infarction when compared to myonecrosis biomarkers. Conclusions IL-6 levels were associated with the severity of CAD assessed by the GS. Based on the highest levels of IL-6 measured in patients with STEMI, our study strongly suggests that IL-6 could be a powerful marker in evaluating the myocardial necrosis. Trial registration ClinicalTrials.gov Number: NCT03075566 (09/03/2017).

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Serum interleukin-6: Association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease

Cited by 6 publications

References 21 publications

Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: inﬂuence of interleukin-6/6R gene polymorphisms on inﬂammatory markers

Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: inﬂuence of interleukin-6/6R gene polymorphisms on inﬂammatory markers

Association between IL-18/18R gene polymorphisms and coronary artery disease: influence of IL-18/18R genetic variants on cytokine expression

Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention

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