Serum interleukin‐17 levels are related to clinical severity in allergic rhinitis

Ciprandi, Giorgio; Amici, Mara De; Murdaca, Giuseppe; Fenoglio, Daniela; Ricciardolo, Fabio Luigi Massimo; Marseglia, Gian Luigi; Tosca, Maria Angela

doi:10.1111/j.1398-9995.2009.02010.x

Cited by 117 publications

(120 citation statements)

References 17 publications

(19 reference statements)

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“…In addition, IL-17A may play a role in the development of various allergic diseases that have classically been considered to be Th2-mediated disorders (17). Moreover, IL-17A may be considered a new biomarker ofdisease progression and allergy severity as recently demonstrated in allergic rhinitis (8)(9). However, to date there have only been studies that investigated 11-17 at serum level.…”

Section: Discussionmentioning

confidence: 99%

“…The skin prick test was performed according to the guidelines ofthe European Academy ofAllergy and Clinical Immunology (13), using a common panel as previously reported (8)(9).…”

Section: Methodsmentioning

confidence: 99%

“…However, it has been further shown that some patients with allergic rhinitis, due to birch allergy and evaluated outside the pollen season, may have detectable serum IL-17 levels which are related to some inflammatory parameters (8). More recently, it was shown that serum IL-17 levels were significantly related with clinical symptoms, drug use, and peripheral eosinophils in patients with pollen-induced AR evaluated during the pollen season (9). Thus, serum IL-17 might be considered a biomarker of severe allergy in AR patients (8)(9).…”

mentioning

confidence: 99%

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Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

Ciprandi

Castellazzi

Fenoglio

et al. 2010

Int J Immunopathol Pharmacol

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Th17 is a subset of T helper lymphocytes and exerts pro-inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in the most severe patients with birch allergy studied both outside and during the pollen season. This study aims to compare the frequency of peripheral IL-17-producing T:cells in children with allergic rhinitis and in healthy controls. Ten children with allergic rhinitis and 5 healthy non-allergic subjects were evaluated. Th17 were evaluated by intracellular staining in ex-vivo T cell compartment. Ex-vivo PBMNC evaluation showed that allergic patients had higher frequencies of IL-17 producing T cells, both concerning CD4+ and CD8+ cells. In particular, there is a subset co-expressing IL-17 and IFN-y both for CD4+ and CD8+ cells. In conclusion, this preliminary study suggests a possible role of Th-17 cells in the response to allergens in children.

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Section: Discussionmentioning

confidence: 99%

“…The skin prick test was performed according to the guidelines ofthe European Academy ofAllergy and Clinical Immunology (13), using a common panel as previously reported (8)(9).…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

Ciprandi

Castellazzi

Fenoglio

et al. 2010

Int J Immunopathol Pharmacol

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“…Klemens et al (14) reported that IL-17 was detectable in the excretions of viral rhinitis patients and AR patients, but the IL-17 level in the viral rhinitis was dramatically higher than that in the AR patients. In addition, Ciprandi et al (15) found, in the pollen season, the serum level of IL-17 was closely relevant with the severity of clinical manifestations in patients with pollen induced AR. In the present study, our result revealed the serum level of IL-17 was markedly higher in AR patients than in healthy controls (P<0.05), which suggests IL-17 may play a crucial role in the pathogenesis of AR.…”

Section: Discussionmentioning

confidence: 99%

Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis Patients

Huang¹,

Yang²,

Chen³

et al. 2011

Journal of Medical Biochemistry

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Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis PatientsThe present study aimed to investigate the expressions of interleukin-17 (IL-17), IL-21 and IL-23 in the serum of allergic rhinitis (AR) patients and to explore their relationship with special IgE (sFgE) in the serum. AR patients (n=24) and healthy subjects (n=12) were recruited and serum samples were collected. The serum level of IgE specific for inhalant allergens was determined using the automatic quantitative immunofluorescence analysis system, and the contents of IL-17, IL-21 and IL-23 in the serum were detected using ELISA. The level of serum IgE in the healthy individuals was categorized as grade 0 and that in the AR patients as grade 2-6. The mean contents of IL-17, IL-21 and IL-23 were 164.71 ±39.37 pg/mL, 199±97.86 pg/mL and 78.94±26.33 pg/mL, respectively, in the AR patients, and 67.75±18.24 pg/mL, 7.58±5.49 pg/mL and 13.58± 3.93 pg/mL, respectively, in the healthy subjects. Statistical analysis showed the serum levels of IL-17 and IL-23 in the AR patients were markedly higher than those in the healthy subjects, however, no significant difference was noted in the content of IL-21. Furthermore, the IL-17 level was positively related to the levels of IL-23 and IgE and the IL-23 level was positively related to the IgE level among AR patients, but no relations were observed between the IL-21 level and levels of IL-17, IL-23 and IgE. Our study indicates IL-17 and IL-23 may play an important role in the pathogenesis of AR and maybe IL-21 is not involved in the occurrence of AR.

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“…13,19,20 IL-17 has important roles in bridging innate and adaptive immunity, and is involved in the host defense against extracellular pathogens, the pathophysiology of autoimmune diseases, and allograft rejection of solid organs. [21][22][23][24][25][26][27][28][29] Moreover, several reports have so far shown that Th17 cells and IL-17 has a significant impact on the development of acute GVHD in mouse models. [30][31][32][33][34][35] Recent reports have shown association of SNPs in the IL-17 gene with autoimmune diseases such as rheumatoid arthritis and ulcerative colitis.…”

Section: Introductionmentioning

confidence: 99%

A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

Espinoza

Takami

Onizuka

et al. 2011

Bone Marrow Transplant

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IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLAmatched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP). In the discovery study, the presence of a 197A genotype in the recipient resulted in a higher incidence of grades II-IV acute GVHD (hazard ratio (HR), 1.87; 95% confidence interval (CI), 1.23-2.85; P ¼ 0.004). The donor IL-17A genotype did not significantly influence the transplant outcomes. The validation study showed a trend toward an association of the recipient 197A genotype with an increased risk of grades III-IV acute GVHD (HR, 5.84; 95% CI,; P ¼ 0.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95% CI, 1.29-11.59; P ¼ 0.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD.

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Serum interleukin‐17 levels are related to clinical severity in allergic rhinitis

Abstract: This study provides evidence that serum IL-17 level assessment might be considered to classify allergy severity.

Cited by 117 publications

References 17 publications

Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

Expressions of IL-17, IL-21 and IL-23 in the Serum of Allergic Rhinitis Patients

A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

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