Serum Interleukin-10 and Interleukin-17 Levels in Papillary Carcinoma and Their Relationship with Prognosis

Abstract

Object: To investigate the levels of serum interleukin-10 (IL-10) and IL-17 in papillary thyroid carcinoma (PTC) and their relationship with prognosis. Method: 120 PTC patients who underwent radical mastectomy in the Department of Thyroid and Mammary Surgery of Cangzhou Central Hospital from January 2018 to April 2019 were randomly selected as the experimental group, and 120 healthy people who matched 1:1 with the hospital physical examination center in the same period were selected as the control group according to the sex, age and body mass index of the experimental group. Compare the levels of serum IL-10 and IL-17 between the two groups, analyze the relationship between the levels and the pathological features of PTC patients, draw the characteristic curve of subjects' working characteristics, and calculate the area under the curve (AUC) to evaluate the diagnostic value of serum IL-10 and IL-17 for PTC. All patients were followed up for 12 months after operation. Imaging and pathological examination results were used as prognostic indicators. Kaplan-Meier survival analysis was used to analyze the relationship between serum IL-10 and IL-17 levels and the prognosis of PTC patients. COX regression analysis was used to analyze the prognostic factors of PTC patients. Result: The levels of serum IL-10 and IL-17 in experimental group were significantly higher than those in control group (P<0.05). Comparison of serum IL-10 levels in PTC patients with different tumor diameters and lymphatic metastasis showed statistically significant difference (P<0.05). The level of IL-17 in serum of PTC patients with different TNM stages, differentiation degree and lymphatic metastasis was statistically significant (P<0.05). The diagnostic value of serum IL-10 combined with IL-17 in PTC is significantly higher than that of single detection (P<0.05). According to the median serum IL-10 and IL-17 for PTC diagnosis, the postoperative recurrence rate of IL-10 high expression group was significantly higher than that of IL-10 low expression group, and the postoperative recurrence rate of IL-17 high expression group was significantly higher than that of IL-17 low expression group (P<0.05). TNM stage, IL-10 level and IL-17 level are independent risk factors for postoperative recurrence of PTC patients (P<0.05). Conclusion: The elevated levels of serum IL-10 and IL-17 in PTC patients are related to TNM stage, degree of differentiation, maximum tumor diameter and lymphatic metastasis, and are independent risk factors for postoperative recurrence of PTC patients, which may be a reference index for disease diagnosis and prognosis evaluation.