Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

Pihlajamäki, Jussi; Kuulasmaa, Tiina; Kaminska, Dorota; Simonen, Marko; Kärjä, Vesa; Grönlund, Sari; Pääkkönen, Matti; Kainulainen, Sakari; Punnonen, Kari; Kuusisto, Johanna; Gylling, Helena; Laakso, Markku

doi:10.1016/j.jhep.2011.10.005

Cited by 89 publications

(67 citation statements)

References 41 publications

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“…Because XBP1 splicing also associated with cholesterol concentration of small VLDL, IDL, LDL subclasses and medium HDL (r s = 0.220-0.313, P < 0.05), endoplasmic reticulum stress could potentially be a link between cholesterol metabolism and NASH. Although the PNPLA3 genotype has been associated with liver fat ( 15,31 ), and also tended to associate with steatosis in our study ( P = 0.080, 2 test), there was no association of the PNPLA3 genotype with serum lipids (all P > 0.2, data not shown).…”

Section: Vldl and Ldl Cholesterol Associates With Liver Infl Ammationcontrasting

confidence: 61%

“…All patients undergoing obesity surgery in Kuopio University Hospital are recruited into our ongoing study investigating metabolic consequences of obesity surgery (Kuopio Obesity Surgery Study) ( 14,15 …”

Section: Subjectsmentioning

confidence: 99%

“…Plasma glucose, insulin, serum total cholesterol, HDL cholesterol, and triglyceride levels were analyzed as described before ( 14,15 ).…”

Section: Laboratory Determinationsmentioning

confidence: 99%

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Lipoprotein subclass metabolism in nonalcoholic steatohepatitis

Männistö

Simonen

Soininen

et al. 2014

Journal of Lipid Research

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Section: Vldl and Ldl Cholesterol Associates With Liver Infl Ammationcontrasting

confidence: 61%

Section: Subjectsmentioning

confidence: 99%

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Lipoprotein subclass metabolism in nonalcoholic steatohepatitis

Männistö

Simonen

Soininen

et al. 2014

Journal of Lipid Research

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“…Moreover, desmosterol levels also correlated with serum levels of interleukin 1 receptor antagonist (IL1-RA) (r ¼ 0.157, P ¼ 2 Â 10 À5 ), a marker of lobular inflammation and NAFLD activity score in NASH. 25 …”

Section: Resultsmentioning

confidence: 99%

Desmosterol in human nonalcoholic steatohepatitis

et al. 2013

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Dysregulation of the cholesterol synthesis pathway and accumulation of cholesterol in the liver are linked to the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we investigated the association of serum and liver levels of cholesterol precursors with NASH. Liver histology was assessed in 110 obese patients (Kuopio Obesity Surgery Study [KOBS] study, age 43.7 6 8.1 years [mean 6 standard deviation, SD], body mass index [BMI] 45.0 6 6.1 kg/m 2 ). Serum and liver levels of cholesterol precursors were measured with gas-liquid chromatography. The association between cholesterol precursors and serum alanine aminotransferase (ALT), as a marker of liver disease, was also investigated in a population cohort of 717 men (Metabolic Syndrome in Men Study [METSIM] study, age 57.6 6 5.8 years, BMI 27.1 6 4.0 kg/m 2 ). Serum desmosterol levels and the desmosterol-tocholesterol ratio were higher in individuals with NASH, but not in individuals with simple steatosis, compared to obese subjects with normal liver histology (P 5 0.002 and P 5 0.003, respectively). Levels of serum and liver desmosterol correlated strongly (r 5 0.667, P 5 1 3 10 29 ), suggesting a shared regulation. Both serum and liver desmosterol levels correlated positively with steatosis and inflammation in the liver (P < 0.05). Serum desmosterol had a higher correlation with the accumulation of cholesterol in the liver than serum cholesterol. Serum desmosterol levels (P 5 2 3 10 26 ) and the serum desmosterol-tocholesterol ratio (P 5 5 3 10 25 ) were associated with serum ALT in the population study. Conclusion: Levels of desmosterol in serum and the liver were associated with NASH. These results suggest that serum desmosterol is a marker of disturbed cholesterol metabolism in the liver. Whether desmosterol has a more specific role in the pathophysiology of NASH compared to other cholesterol precursors needs to be investigated. (HEPATOLOGY 2013;58:976-982)

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“…The Kuopio Obesity Surgery (KOBS) study is an ongoing study, with 89 individuals (age 46.3 ± 8.8 years, BMI 44.9 ± 6.3 kg/m 2 ) currently included in it ( Table 1 ) ( 11 ). Clinical parameters were assessed prior to the gastric bypass surgery (at baseline, n = 89) and at 1 year after surgery (follow-up, n = 64).…”

Section: Study Populationmentioning

confidence: 99%