1998
DOI: 10.1507/endocrj.45.suppl_s61
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Serum Insulin-Like Growth Factor II in 44 Patients with Non-Islet Cell Tumor Hypoglycemia

Abstract: Abstract.Serum insulin-like growth factor II (IGF-II) was characterized by radioimmunoassay and Western immunoblot in 44 patients with non-islet cell tumor hypoglycemia (NICTH). 31 of 44 patients with NICTH had big IGF-II in sera.When the presence of IGF-II in tumors from 20 patients was investigated, IGF-II in tumors was detected in 18 patients and these patients had big IGF-II in sera. In two patients whose tumors did not contain IGF-II, big IGF-II in sera was not detected.In six patients with IGF-II in tumo… Show more

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Cited by 70 publications
(69 citation statements)
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“…NICHT consists of a rare syndrome characterized by the presence of a solid tumor and severe fasting hypoglycemia determined by an insulin-independent pathway (11). In 1929, Nadler and Wolfer described a case of hypoglycemia associated with liver carcinoma for the first time (11), and Daughaday and cols.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…NICHT consists of a rare syndrome characterized by the presence of a solid tumor and severe fasting hypoglycemia determined by an insulin-independent pathway (11). In 1929, Nadler and Wolfer described a case of hypoglycemia associated with liver carcinoma for the first time (11), and Daughaday and cols.…”
Section: Discussionmentioning
confidence: 99%
“…In 1929, Nadler and Wolfer described a case of hypoglycemia associated with liver carcinoma for the first time (11), and Daughaday and cols. were the first to demonstrate the presence of IGF-2 in a hypoglycemia-producing tumor (12).…”
Section: Discussionmentioning
confidence: 99%
“…Currently, most cases with NICTH are attributed to excessive production of IGF-II by the tumors based on the recent accumulating evidence that these tumors produce and secrete IGF-II (1)(2)(3)(4)(5)(6)(7)(8). The diagnosis of the present patient with NICTH was consistent with that of HMW form IGF-IIproducing tumor causing hypoglycemia for the following reasons: 1) preoperative high IGF-II levels; 2) hypoglycemia improved and serum IGF-II levels decreased to normal after tumor resection; 3) the presence of circulating HMW form IGF-II in patient's serum by Western blotting; 4) the expression of IGF-II mRNA and protein by the tumor as demonstrated by real-time quantitative RT-PCR and immunohistochemistry, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…The present patient had elevated serum levels of IGF-II consisting predominantly of HMW (approximately 19.8 kDa) form. The HMW form IGF-II has been shown to mimic insulin's effects more effectively than a mature (7.5 kDa) form (1,2,(4)(5)(6)(7)(8). In normal subjects, about two-thirds of the circulating mature form IGF-II is present as a ternary 150 kD complex with IGF binding protein-3 (IGFBP-3) and acid-labile subunit (ALS).…”
Section: Discussionmentioning
confidence: 99%
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