Serum Insulin-Like Growth Factor-I Levels and Potential Risk of Type 2 Diabetes

Ong, Ken K.; Sandhu, Manjinder S.

doi:10.1159/000074514

Cited by 28 publications

(22 citation statements)

References 31 publications

(36 reference statements)

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“…Epidemiologic studies suggest that high levels of IGF-1 are associated with increased risk of breast cancer and higher levels of breast density, but only among pre-menopausal women [29][30][31]33]. There are few studies that have examined IGF-I levels in type II diabetes, but recent prospective epidemiologic studies suggest that higher IGF-I levels may actually lower diabetes risk [48,49]. One study that compared obese diabetics, obese non-diabetics, and lean controls, found that serum IGF-I were elevated among obese women with and without type II diabetes, although only the difference between non-diabetics and controls achieved statistical significance [50].…”

Section: Discussionmentioning

confidence: 99%

Association of diabetes with mammographic breast density and breast cancer in the Minnesota breast cancer family study

Sellers,

Jensen,

Vierkant

et al. 2007

Cancer Causes Control

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Data from the Minnesota Breast Cancer Family Study cohort (n=6,130 women) were used to examine the association of type II diabetes with mammographic percent density and incident breast cancer (BC). Exposures and outcomes were self-reported. The first set of analyses evaluated diabetes (DM) as a risk factor for breast cancer. A total of 403 women (6.6%) reported a diagnosis of type II diabetes and 333 women reported an incident breast cancer. Women who reported type II diabetes had an age-adjusted relative risk (RR) for breast cancer of 1.44 (95% CI 0.89-2.32) compared to those who did not. Adjustment for covariates strengthened the association (RR 1.61, 95% CI 0.98-2.62). Mammograms were retrieved on women over the age of 40 and percent density was estimated with a user-assisted thresholding program. Cross-sectional analyses revealed that mean levels of mammographic density were not statistically significantly different between diabetic and non-diabetic women. Results were similar within strata of menopausal status. Breast cancer cases with diabetes did not have a significantly higher percent density than cases without diabetes. Our findings suggest that breast cancer risk may be increased among women with type II diabetes, but that type II diabetes does not significantly influence mammographic breast density.

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Section: Discussionmentioning

confidence: 99%

Association of diabetes with mammographic breast density and breast cancer in the Minnesota breast cancer family study

Sellers,

Jensen,

Vierkant

et al. 2007

Cancer Causes Control

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“…On the other hand, in an adult study population high circulating concentrations of IGF-I were associated with a reduced risk for developing impaired glucose tolerance and type-2 diabetes (34). It has been suggested that IGF-I might have GH-independent effects on insulin sensitivity, and circulating IGF-I levels could have an important role in the regulation of insulin sensitivity and maintenance of insulin secretion (35).…”

Section: Discussionmentioning

confidence: 99%

Serum markers of GH and insulin action in 12-year-old children born small for gestational age

Tenhola

Halonen²,

Jääskeläinen³

et al. 2005

eur j endocrinol

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Objectives: Our aim was to determine whether markers of growth hormone and insulin action differ between children born small for gestational age (SGA) and those born of an appropriate size for gestational age (AGA). Design: Fifty-five SGA children and their 55 age-and sex-matched AGA control subjects were studied in a case-control setting at 12 years of age. Methods: We examined serum concentrations of insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (IGFBP)-1 and IGFBP-3, sex hormone binding globulin (SHBG), leptin, fasting insulin, and blood glucose. Insulin sensitivity was evaluated by the homeostasis model assessment for insulin resistance (HOMA-IR). Results: The body mass index (BMI), sex, and puberty-adjusted mean serum IGF-I concentration was higher in the SGA than in the AGA children (303.4 vs 282.3 mg/l, P ¼ 0.006). The mean serum concentrations of IGF-II, IGFBP-I, IGFBP-3, SHBG, fasting insulin, blood glucose and HOMA-IR did not differ between the SGA and the AGA group. The BMI, sex, and puberty-adjusted mean serum leptin concentration was lower in the SGA than in the AGA children (7.9 vs 10.1 mg/l, P ¼ 0.037). In multiple logistic regression analysis, high HOMA-IR predicted high serum IGF-I levels in the SGA children (odds ratio 8.3; 95% confidence interval 1.7-41; P ¼ 0.010), whereas in the AGA group HOMA-IR did not associate with the serum IGF-I level. Conclusions: The BMI, sex, and puberty-adjusted mean serum IGF-I concentration was significantly higher and the leptin concentration was lower in the SGA than in the AGA children. No differences were found in the indices of insulin action or sensitivity between the SGA and AGA children at 12 years of age. However, HOMA-IR strongly associated with serum IGF-I levels in the SGA children.European Journal of Endocrinology 152 335-340

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“…The data from the literature suggest that IGF-1 may have beneficial effect on glucose homeostasis, due to its glucose lowering and insulin sensitizing actions (Kabir et al, 2010). Adult studies suggest that lower IGF-1 level in childhood predict increased risk for developing insulin resistance and type 2 diabetes (Dunger et al, 2003). Moreover, previous studies reported that circulating fasting free IGF-1 were higher in obese subjects compared with normal weight controls, whereas total IGF-1 were not significantly different between the groups (Nam et al, 1997).…”

Section: Discussionmentioning

confidence: 99%