Serum insulin‐like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin

Landin‐Wllhelmsen, Kerstin; Wllhelmsen, Lars; Lappast, George; Rosén, Thord; Lindstedt, Göran; Lundberg, Per‐Arne; Bengtsson, Bengt‐Åke

doi:10.1111/j.1365-2265.1994.tb02556.x

Cited by 318 publications

(239 citation statements)

References 35 publications

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“…During puberty, however, IGF-I levels are higher in girls than in boys, even when corrected for Tanner stages (13). In young adults, IGF-I levels are higher in females, but in mid-life adult men display higher IGF-I levels (10,14). These differences are believed mainly to depend on the GH status, which subsequently may be influenced by sex hormones.…”

Section: Discussionmentioning

confidence: 91%

Impact of gender and androgen status on IGF-I levels in normal and GH-deficient adults

Fisker

Jørgensen

Vahl

et al. 1999

European Journal of Endocrinology

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Objective: The regulation of IGF-I levels is complex and not only dependent on GH status, as the diagnostic sensitivity of serum IGF-I levels for GH deficiency (GHD) in adults is low. Other GH-related parameters have so far not proven to be of additional diagnostic value in GHD adults. In the present study we evaluated the impact of gender and androgen status on IGF-I levels and the diagnostic value of IGF-I and GH-related parameters in a population of adult hypopituitary patients and age-and gender-matched healthy subjects. Design: A cross-sectional study.

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Section: Discussionmentioning

confidence: 91%

Impact of gender and androgen status on IGF-I levels in normal and GH-deficient adults

Fisker

Jørgensen

Vahl

et al. 1999

European Journal of Endocrinology

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“…but have generally similar serum IGF-I levels [3,4]. As expected, female with GH deficiency need a higher dose of GH than male to maintain normal serum IGF-I levels [5,6].…”

mentioning

confidence: 86%

Gender differences in serum GH and IGF-I levels and the GH response to dynamic tests in patients with acromegaly

et al. 2010

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“…Studies among healthy adults have reported a null association (2-4), a positive association (5), an inverse association (6)(7)(8)(9), and a nonlinear association (10,11) between BMI and IGF-I levels. The nonlinear associations were similar to what we observed in Japanese Americans.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies, however, have been inconsistent with respect to the relationships between adiposity and circulating levels of IGF proteins (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Studies among healthy adults have reported a null association (2-4), a positive association (5), an inverse association (6)(7)(8)(9), and a nonlinear association (10,11) between body mass index (BMI) and IGF-I levels. We are unaware of any study that has looked at possible ethnic differences in the relationship between obesity and circulating IGF-I, and this may be important in addressing the metabolic basis for ethnic differences in cancer risk.…”

Section: Introductionmentioning

confidence: 98%

Ethnic Disparity in the Relationship between Obesity and Plasma Insulin-Like Growth Factors: The Multiethnic Cohort

Henderson

Goran

Kolonel

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Previous studies on the relationship between obesity and circulating insulin-like growth factor (IGF) hormones show inconsistent findings and have not considered the possibility of racial/ethnic -specific differences that may exist. We therefore examined the relationship between obesity status [as measured by body mass index (BMI)] and plasma levels of the IGF proteins, IGF-I, IGF-binding protein 3 (IGFBP-3), and the molar ratio of IGF-I/IGFBP-3 in Whites, African Americans, Latinos, Japanese Americans, and Native Hawaiians from the ongoing Hawaii and Los Angeles Multiethnic Cohort Study. We measured plasma IGF-I and IGFBP-3 by ELISA in a random sample of 811 Multiethnic Cohort participants (53% male, age range = 47-82 at blood draw). In a multivariate regression of IGF-I levels, we found a statistically significant interaction between race/ethnicity and obesity status (P = 0.005).Plasma IGF-I levels declined with increasing BMI most dramatically in Latinos and Japanese. This decline was attenuated in Whites and absent in African-American and Native Hawaiian subjects. In Japanese, the quadratic term (BMI 2 ) was statistically significant in a multivariate model (P = 0.002). In Latinos, the adjusted least-squares mean IGF-I levels in ng/mL for BMI < 25, 25 to 29.99, and z30 were 184.6, 147.7, and 132.7, respectively. No interaction between race/ethnicity and BMI explained the plasma IGFBP-3 levels in these data. These results may help to resolve the uncertainty in the relationship between circulating IGF levels and obesity and highlight the potential importance of racial/ethnic -specific effects among these factors in explaining ethnic disparities in obesity-related cancers. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2298 -302)

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Serum insulin‐like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin

Abstract: The present data can be used as reference values for IGF-I (at least in Caucasians) for the diagnosis of growth hormone disturbances and as guidelines for growth hormone substitution.

Cited by 318 publications

References 35 publications

Impact of gender and androgen status on IGF-I levels in normal and GH-deficient adults

Impact of gender and androgen status on IGF-I levels in normal and GH-deficient adults

Gender differences in serum GH and IGF-I levels and the GH response to dynamic tests in patients with acromegaly

Ethnic Disparity in the Relationship between Obesity and Plasma Insulin-Like Growth Factors: The Multiethnic Cohort

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