Serum Insulin-Like Growth Factor-1 Concentrations Are Reduced in Severely Obese Women and Raise After Weight Loss Induced by Laparoscopic Adjustable Gastric Banding

Galli, Giulia; Pinchera, Aldo; Piaggi, Paolo; Fierabracci, Paola; Giannetti, Monica; Querci, Giorgia; Scartabelli, Giovanna; Manetti, Luca; Ceccarini, Giovanni; Martinelli, Silvia; Salvo, Clelia Di; Anselmino, Marco; Bogazzi, Fausto; Landi, Alberto; Vitti, Paolo; Maffei, Margherita; Santini, Ferruccio

doi:10.1007/s11695-012-0669-1

Cited by 47 publications

(31 citation statements)

References 27 publications

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“…1). This blunted effect of loading in the old participants on leg lean mass may possibly be attributed to lower levels of anabolic circulating hormones such as insulin-like growth factor-1 (IGF-I) (Galli et al 2012) and the increase of catabolic cytokines such as interleukin-6 (IL-6) and tumour necrosis factor α (TNF-α) (Visser et al 2002; Hotamisligil et al 1995) seen in older vs. younger individuals.…”

Section: Discussionmentioning

confidence: 99%

Combined effects of body composition and ageing on joint torque, muscle activation and co-contraction in sedentary women

Tomlinson

Erskine

Morse

et al. 2014

AGE

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This study aimed to establish the interplay between body mass, adiposity, ageing and determinants of skeletal muscle strength. One hundred and two untrained healthy women categorised by age into young (Y) (mean ± SD, 26.7 ± 9.4 years) vs. old (O) (65.1 ± 7.2 years) were assessed for body fat, lean mass, plantar flexion and dorsiflexion maximum voluntary isometric contraction (MVC) torque, muscle activation capacity and antagonist muscle co-contraction. MVC torque normalised to body mass in the obese group was 35 and 29 % lower (p < 0.05) in Y and 34 and 31 % lower (p < 0.05) in O, compared with underweight and normal weight individuals, respectively. Y with ≥40 % body fat had significantly lower activation than Y with <40 % body fat (88.3 vs. 94.4 %, p < 0.05), but O did not exhibit this effect. Co-contraction was affected by ageing (16.1 % in O vs. 13.8 % in Y, p < 0.05) but not body composition. There were significant associations between markers of body composition, age, strength and activation capacity, with the strongest correlation between muscle strength and total body mass (r2 = 0.508 in Y, p < 0.001, vs. r2 = 0.204 in O, p < 0.01). Furthermore, the age-related loss in plantar flexion (PF) MVC torque was exacerbated in obese compared to underweight, normal weight and overweight individuals (−0.96 vs. −0.54, −0.57 and −0.57 % per year, p < 0.05). The negative impact of adiposity on muscle performance is associated with not only muscular but also neural factors. Overall, the effects of ageing and obesity on this system are somewhat cumulative.

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Section: Discussionmentioning

confidence: 99%

Combined effects of body composition and ageing on joint torque, muscle activation and co-contraction in sedentary women

Tomlinson

Erskine

Morse

et al. 2014

AGE

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“…It may be hypothesized that a too rapid and intense loss of weight, obtained by some bariatric surgical procedures, mostly those with a malabsorptive component, may favor a persistent pathologically low IGF1. Galli et al (23) showed a good correlation between a WL of about 23% and IGF1 increase, after 2 years of follow-up with banding. On the other hand, other investigators, i.e.…”

Section: Discussionmentioning

confidence: 91%

“…The somatotropic axis is also affected by severe obesity, and reduced basal and stimulated GH secretion and IGF1 concentrations have been described in obese subjects (15,16,17,18,22,23). The somatotropic axis is relevant for healthy condition at all ages and it is understood that low IGF1 concentrations have been closely associated with cardiovascular disease (11), abnormal abdominal adiposity accumulation, low quality of life, decreased muscle mass, and abnormal bone homeostasis (11,12).…”

Section: Discussionmentioning

confidence: 99%

“…As we did not measure IGF1 in our series at 6 months, we cannot report what happened at this time point of follow-up. Recently, Mittempergher et al (24) have analyzed the (16,17,18,19,20,21,22,23,24). In this study, evaluation at 12 months of follow-up after bariatric surgery was chosen in order to avoid the first 6 months in which rapid WL usually takes place, which may greatly influence IGF1 concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin-like growth factor 1 (IGF1) has been reported to be low in a substantial proportion of patients with severe obesity in association with normal or high concentrations of its binding proteins (IGFBPs), mostly IGFBP3 (9,12). This functional GH deficiency state in obesity is not always reversed after hypocaloric diet, while weight loss (WL) obtained by bariatric surgery seems to be more effective in doing so (13,14,15,16,17,18,19,20,21,22,23,24). However, as bariatric surgery may also have a catabolic and intense impact on nutritional status, changes in IGF1 may eventually be of an unfavorable nature.…”

Section: Introductionmentioning

confidence: 99%

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IGF1 modifications after bariatric surgery in morbidly obese patients: potential implications of nutritional status according to specific surgical technique

Pellitero

Granada

Martínez

et al. 2013

European Journal of Endocrinology

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Objectives: IGF1 is decreased in morbidly obese (MO) patients and its changes after bariatric surgery weight loss (WL) are not well known. The aim of this study was to analyse IGF1 modifications in MO patients after WL and its relationship to ghrelin and to different types of surgeries. Design: Retrospective follow-up study at the University Medical Center. Methods: One hundred and nine MO patients (age 44.1G9.3, BMI 51.74G8.75 kg/m 2 ) were evaluated at baseline and 1 year after surgery: 28 sleeve gastrectomy (SG), 31 distal modified (m), and 50 ringed (r) Roux-en-Y gastric bypass (RYGBP) surgery. Changes in IGF1, IGFBP3, ratio IGF1:IGFBP3, and ghrelin were evaluated 1 year after surgery. Results: Baseline prevalence of low IGF1 (defined by S.D. IGF1!K2) was 22%, and %WL 1 year after surgery was 34.9G8.9%. There was a significant decrease in IGFBP3 in all the procedures, an increase in IGF1:IGFBP3 ratio in rRYGBP and SG, but total IGF1 only increased significantly in SG. Albumin concentrations decreased in mRYGBP, did not change in rRYGBP, but increased in SG after surgery. Total ghrelin concentrations increased after both RYGBPs and decreased after SG (P!0.05 in all cases). The prevalence of low IGF1 decreased in SG (28.6 vs 10.1%, PZ0.03) and did not change in RYGPBP techniques. The %albumin change was the only dependent variable associated with the % total IGF1 change. Conclusions: Recovery of low IGF1 after bariatric surgery was specifically related to the albumin modifications induced by surgery and was not related to ghrelin modifications.

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Hypothalamic Growth Hormone/IGF-1 Axis

Colao

Savastano

Somma

2014

Multidisciplinary Approach to Obesity

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Serum Insulin-Like Growth Factor-1 Concentrations Are Reduced in Severely Obese Women and Raise After Weight Loss Induced by Laparoscopic Adjustable Gastric Banding

Cited by 47 publications

References 27 publications

Combined effects of body composition and ageing on joint torque, muscle activation and co-contraction in sedentary women

Combined effects of body composition and ageing on joint torque, muscle activation and co-contraction in sedentary women

IGF1 modifications after bariatric surgery in morbidly obese patients: potential implications of nutritional status according to specific surgical technique

Hypothalamic Growth Hormone/IGF-1 Axis

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