Serum induced CD63 and CD203c activation tests in chronic urticaria

Abstract

<jats:title>Abstract</jats:title>

What is causing this patient's urticaria?

“…[1][2][3] Chronic urticaria affects 0.5% to 1% of the general population and 0.1% to 0.3% of children. 2,[4][5][6] Chronic urticaria can be divided into two subgroups: idiopathic and autoimmune. 5 The autoimmune subgroup is associated with the autoantibodies IgG and IgE, which are capable of inducing mast cell and basophil degranulation.…”

“…3 Chronic autoimmune urticaria can be associated with type I hypersensitivity (autoallergy) or type II hypersensitivity (autoimmunity). 4 Autoallergy occurs when IgE directs against autoallergens such as TPO or interleukin-24 (IL-24) (Figure 4). 1,8 Autoimmunity occurs when mast cells are activated by IgG autoantibodies directed to IgE or its receptor.…”

“…Urticaria is defined as either acute (less than 6 weeks) or chronic (lasting more than 6 weeks) 1-3. Chronic urticaria affects 0.5% to 1% of the general population and 0.1% to 0.3% of children 2,4-6. Chronic urticaria can be divided into two subgroups: idiopathic and autoimmune 5.…”