Serum Indolamine 2,3 Dioxygenase as a Marker in the Evaluation of Allergic Rhinitis

Refaat, Maged; Rehim, Asmaa Saber Mostafa Abdel; Sayed, Hoda Mohamed El; Mohamed, Nesrine A; Khafagy, Ahmed Gamal

doi:10.2500/ajra.2015.29.4210

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…Several studies from our group reported a prevalence of 50–75% among non-atopic individuals with nasal symptoms suggestive of allergy [9,11,23,36]. Nevertheless, the existing literature reflects an extremely wide range of LAR prevalence among non-atopic rhinitis patients (0–100%) [9,21,22,23,24,26,27,28,29,30,31,32,33,34,37]. In recent years, several studies from Asian countries have become available and overall report a lower (<20%) prevalence of LAR as compared to Western countries [26,27,29,33,37].…”

Section: Epidemiologymentioning

confidence: 95%

“…Although large population studies are lacking, different works report that LAR is an underdiagnosed entity, affecting a considerable proportion of non-atopic rhinitis individuals of different countries, ethnic backgrounds, and age ranges [9,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. Several studies from our group reported a prevalence of 50–75% among non-atopic individuals with nasal symptoms suggestive of allergy [9,11,23,36].…”

Section: Epidemiologymentioning

confidence: 99%

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How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians

Eguiluz‐Gracia

Pérez‐Sánchez

Bogas

et al. 2019

JCM

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Chronic rhinitis is a very common disease that can be divided in various phenotypes. Historically, the condition has been classified into the allergic rhinitis (AR) and non-allergic non-infectious rhinitis (NAR) forms, based on the results of the classical biomarkers of atopy: skin prick test and serum allergen-specific IgE However, this classification does not reflect the complexity of the rhinitis syndrome, as illustrated by the existence of non-atopic rhinitis patients who display a nasal reactivity to environmental allergens. This new phenotype has been termed local allergic rhinitis (LAR) and can be only recognized if an additional test such as the nasal allergen challenge (NAC) is integrated in the diagnostic algorithm for chronic rhinitis. Recent data shows that the NAC is a very safe and reliable technique ready for the clinical practice. LAR is a differentiated rhinitis phenotype which often commences during childhood and quickly progresses towards a clinical worsening and the association of comorbidities in other mucosal organs. Recent evidence supports the existence of a bronchial counterpart of LAR (local allergic asthma), which highlights the pathophysiological links between the upper and lower airways and reinforces the united airways concept. Importantly, several controlled studies have demonstrated the ability of allergen immunotherapy to control LAR symptoms while the therapy is being administered. This review emphasizes the need to implement the NAC in the clinical practice in order to facilitate the recognition of LAR patients, allowing for an early prescription of specific therapies with disease-modifying potential.

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Section: Epidemiologymentioning

confidence: 95%

Section: Epidemiologymentioning

confidence: 99%

How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians

Eguiluz‐Gracia

Pérez‐Sánchez

Bogas

et al. 2019

JCM

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“…TNSS is the sum of four individual symptom scores (sneezing, rhinorrhea, nasal congestion, and nasal itching), and each symptom ranged from 0 to 3, resulting in a possible score of 0–12 (detailed described in Supplementary Table S1 ). Based on TNSS, AR patients were categorized into the mild AR (MAR) group (TNSS ≤4) and the moderate–severe AR (MSAR) group (TNSS >4) according to recommendation by previous publications ( Refaat et al, 2015 ; Adamko et al, 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Circulating MIF Associated With Disease Severity and Clinical Response of Sublingual Immunotherapy in House Dust Mite–Induced Allergic Rhinitis

et al. 2021

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Background: Macrophage migration inhibitory factor (MIF) is described as a pro-inflammatory cytokine involved in many inflammatory and allergic disorders, but the role of MIF in allergic rhinitis (AR) remains poorly clarified. The aim of this study was to investigate the association between circulating MIF levels and house dust mite (HDM)-induced AR, and evaluate MIF as a potential biomarker in reflecting disease severity and predicting the clinical response of sublingual immunotherapy (SLIT) in HDM-induced AR patients.Methods: In this study, we enrolled 160 persistent HDM-induced AR patients (AR group), including 48 mild AR patients (MAR group) and 112 moderate–severe AR patients (MSAR group), and 77 healthy controls (HC group). Circulating levels of MIF were measured by ELISA, and the relationship between MIF concentrations and disease severity was assessed. In the MSAR group, 106 patients were assigned to receive SLIT for 3 years. At the end of the study, patients were categorized into good response group and poor response group, and associations between clinical variables or biomarkers and clinical response were analyzed by the multivariate regression analysis.Results: The concentrations of serum MIF were significantly higher in AR patients than in HCs, especially in those with MSAR. Moreover, circulating MIF levels were positively correlated with TNSS, VAS, serum HDM–specific IgE, total IgE, blood eosinophil count, and blood eosinophil percentage (all p < 0.05). Eighty MSAR patients finally completed SLIT, 45 patients obtained good response, and 35 patients resulted in poor response. The serum levels of MIF were significantly lower in the good-response group than in the poor-response group (p < 0.001). The receiver operating characteristic analysis for MIF showed good accuracy for predicting clinical response of SLIT (area under the curve = 0.877, p < 0.001). The multivariate regression analysis demonstrated that serum MIF was an independent factor for SLIT responsiveness.Conclusion: Serum MIF appeared to be an important biological indicator in reflecting disease severity and an independent predictor for clinical responsiveness of SLIT in HDM-induced AR patients.

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“…16 Indolamine-2,3-dioxygenase is a metabolic enzyme induced by immune activation. Refaat et al 17 found a significant increase in indolamine-2,3-dioxygenase levels in allergic rhinitis compared with subjects without allergy. Indolamine-2,3-dioxygenase was positively correlated with total serum IgE levels.…”

Section: T His Issue Of American Journal Of Rhinology Andmentioning

confidence: 99%

“…Indolamine-2,3-dioxygenase was positively correlated with total serum IgE levels. 17 Choosing between skin-prick tests and in vitro blood tests to evaluate aeroallergen sensitivity in chronic rhinitis is an important decision. In a comprehensive review, Oppenheimer 18 discusses concerns and advantages of each test that can help clinicians make the right choice in various clinical scenarios.…”

Section: T His Issue Of American Journal Of Rhinology Andmentioning

confidence: 99%

Editorial: Inflammatory and Allergic Diseases of the Upper Airways

Mahdavinia¹

2015

Am J Rhinol�Allergy

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Editorial: Inflammatory and allergic diseases of the upper airways T his issue of American Journal of Rhinology and Allergy (AJRA) covers a diverse selection of articles on basic and clinical aspects of inflammatory diseases of the upper airways. One such disease, chronic rhinosinusitis (CRS), significantly lowers quality of life. Despite recent progress, however, CRS remains poorly understood. A few of the articles in this AJRA issue focus on the pathophysiology of CRS.The literature indicates a role for prostaglandin-E2 and E-prostanoid (EP) receptors in CRS. When comparing EP receptors in CRS subtypes, Xie et al. 1 found enhanced EP1 receptor messenger RNA (mRNA) and protein expression in eosinophilic CRS with nasal polyps (CRSwNP). However, EP4 mRNA levels were higher than EP1, EP2, and EP3 levels in controls; in CRS without nasal polyps (CRSsNP); and in noneosinophilic CRSwNP. 1 Nasal tissue eosinophilia is a hallmark of CRSwNP, especially in patients from Western countries. Results of studies have shown an association between tissue eosinophilia and polyp recurrence. In their retrospective analysis from China of 387 patients with CRSwNP, Lou et al. 2 found a significant correlation between tissue eosinophilia and polyp recurrence. They showed that tissue eosinophils Ͼ27% of total cells or a tissue eosinophil absolute count of Ն55 eosinophils per high power field is a reliable prognostic indicator for nasal polyp recurrence within 2 years after surgery. 2 CRS has been linked to imbalances in the production of eicosanoids (arachidonic acid metabolites), which results from phospholipid hydrolysis by phospholipase A2 (PLA2). Mruwat et al. 3 investigated the expression of PLA2s and multiple cytokines in super-antigen Staphylococcus aureus enterotoxin stimulated human nasal polyps from patients with CRSwNP. Stimulation of nasal polyp cells by S. aureus enterotoxin induced cytokine secretion and enhanced expression of several secretory PLA2 and calciumindependent PLA2, while suppressing cytoplasmic PLA2 expression. This supports a role for secretory PLA2s in the pathophysiology of CRS. 3 Wang et al. 4 evaluated the ethmoid bone tissue samples from a group of patients with CRS by histologic examination and quantitative real-time reverse transcription polymerase chain reaction and showed an increased infiltration of eosinophils in the periosteum, along with neo-osteogenesis in CRS. The investigators found increased expression of TGF-␤1, TGF-␤ receptor I, and p-Smad3 in patients with CRSwNP compared with CRSsNP at the mRNA and protein levels. The investigators concluded that these findings were indicative of a potential role for eosinophils in the bone remodeling process in CRSwNP. 4 Oral steroids are used routinely in the management of CRS. However, providers should be aware of potential adverse effects and complications with these medications. In this issue of AJRA, Poetker 5 comprehensively reviews existing data on the risks of oral steroids and discusses the use of oral steroids in CRS.With the recent emergence o...

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Serum Indolamine 2,3 Dioxygenase as a Marker in the Evaluation of Allergic Rhinitis

Abstract: IDO plays an important role in patients with atopic symptomatic allergic rhinitis, especially with increased levels of IgE. There is no relationship between IDO levels and severity of disease.

Cited by 10 publications

References 30 publications

How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians

How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians

Circulating MIF Associated With Disease Severity and Clinical Response of Sublingual Immunotherapy in House Dust Mite–Induced Allergic Rhinitis

Editorial: Inflammatory and Allergic Diseases of the Upper Airways

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