Serum immunoglobulins in patients with carcinoma of the oral cavity, uterine cervix and breast

Abstract

Serum immunoglobulin levels (IgG, IgA, IgM, IgD and IgE) were estimated in 196 patients with carcinoma of the oral cavity, 172 patients with cervical cancer and 166 patients with breast cancer. The values were compared with those of 50 patients with benign lesions of the breast and cervix and 100 healthy adult controls. Only the serum IgE levels were found to be elevated in the benign group. Serum IgA, IgD and IgE levels were found to be elevated in all the three types of cancers and the levels were found to increase with clinical stage. In carcinoma of uterine cervix IgG levels were also found to be elevated. Immunoglobulins A and D returned to normal after clinical cure whereas IgE remained slightly elevated. IgD and IgE remained high in patients who had residual cancer.

Níveis sérico e salivar de imunoglobulina A em portadores de câncer da boca e orofaringe

“…Nos portadores de câncer de boca e orofaringe os resultados de IgA sérica foram semelhantes a alguns autores 12,18,19,20 , mas significativamente mais baixos do que descritos em outras publicações 11,13,16 . Cabe salientar que os resultados do presente estudo não evidenciaram diferenças nos valores de IgA sérica dos portadores de câncer quando comparados com indivíduos normais.…”

“…Apesar da literatura descrever uma relação positiva entre o estádio da doença e o nível de IgA sérica com um aumento de IgA de acordo com a evolução clínica da doença 11,13,19,20 , não se confirmou este achado na presente pesquisa. O pequeno número de casos no estádio I (quatro) pode ter influído para esta disparidade.…”

Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis

“…Hyperimmunoglobulinaemia is invariably associated with OSMF (16). Therefore, serum immunoglobulin levels are used as parameters to assess the status of humoral immunity (17). Our study aimed at estimation of serum IgG and IgG to assess the role of humoral immune response in OSMF.…”

Serum IgE levels in neurofibromatosis 1

“…A potential link between cancer and the immune system, particularly IgE, has been investigated by numerous researchers, with varied results (Winters & Heiner, 1976; Blondal & Nou, 1981; Ownby et al ., 1982; Berczi et al ., 1983; Jankovic et al ., 1985; Levo et al ., 1985; Vijayakumar et al ., 1986; Lal et al ., 1988; Eckschlager et al ., 2004; Wiemels et al ., 2004). However, there has been little or no research on the role of IgE in the pathogenesis and development of neurofibromatosis, particularly in neurofibromas and plexiform neurofibromas.…”