Serum immunoglobulins in patients with chronic tonsillitis

el-Ashmawy, S; Taha, Ahmed; Fatt-Hi, A.; Basyouni, A.; Zaher, S.

doi:10.1017/s0022215100089829

Cited by 21 publications

(19 citation statements)

References 12 publications

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“…IgM antibodies are produced during the acute phase of infectious diseases and their serum levels decrease 1-3 months after infection but IgG antibodies represent in the chronic infections and their levels are also increased in recurrent infections 10 . Ashmawy et al (1980) 4 in Egypt reported that among patient with chronic tonsillitis, before tonsillectomy the level of IgG and IgA in serum were significantly increased compared to control group, while the IgM level were not changed significantly and two months after tonsillectomy, these increased level of IgG and IgA were significantly reduced than preoperative value but postoperative level value did not differ significantly with control group.…”

Section: Discussionmentioning

confidence: 92%

“…Tonsillar plasma cells produce all five immunoglobulin classes but predominantly IgG and IgA 3 . Since the humoral role of the immune function of the tonsil is its most important one, the immunological function of the tonsil can be assessed by serum immuno-globulin estimations in patients with chronic tonsillitis and in their follow-up after tonsillectomy 4 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of tonsillectomy on humoral immunity

Nasrin

Miah

Datta

et al. 2012

Bangladesh Med Res Counc Bull

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Tonsils are one of the important secondary lymphoid organ in immune system. It remains controversial whether tonsillectomy results in decreased serum immunoglobulin level. The purpose of this study was to observe the effect of tonsillectomy on humoral immunity parameters among the patients with tonsillar disease. Total group A 70 patients up to the age of 18 years, who were enrolled for tonsillectomy and 30 age matched children group B were included for comparative study. Serum IgG, IgM and IgA levels were measured in all 70 patients before tonsillectomy and in 56 patients who came for 1 st follow-up after one month and 30 patients who came for 2nd follow up after three months of tonsillectomy. Serum IgG, IgM and IgA levels were also measured in group B children. Serum IgG, IgM and IgA levels in patients of group A did not show any significant difference in comparison to group B. One month after tonsillectomy the level of IgG was slightly decreased and IgM and IgA were increased compared to preoperative value but not statistically significant. All IgG, IgM and IgA were also not significantly altered in comparison to group B. Three months after tonsillectomy serum IgG, IgM and IgA level were found decreased in comparison to pre operative value and group B, among which difference of only IgG was significant. After tonsillectomy humoral parameters were found reduced but overall impact on humoral immune status was not significantly altered.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of tonsillectomy on humoral immunity

Nasrin

Miah

Datta

et al. 2012

Bangladesh Med Res Counc Bull

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“…Similarly, an increase in serum immunoglobulin levels has been observed in patients with chronic adenotonsillitis in previous studies. 7,9,14,17 On the contrary, no significant variation in serum IgG, IgA and IgM levels before and after tonsillectomy has been noted by some authors. 5 IgM antibodies are produced in acute phase of infectious diseases and their levels decrease in 1-3 months after acute infection.…”

Section: Subramaniam V Et Al Int J Otorhinolaryngol Head Neck Surg mentioning

confidence: 90%

“…Observations of this study concur with observations in previous studies. 1,3,[7][8][9][16][17][18] In most previous studies, levels of immunoglobulins were increased before adenotonsillectomy and decreased after surgery. This was due to removal of infected tissue and continuous antigenic stimulation.…”

Section: Subramaniam V Et Al Int J Otorhinolaryngol Head Neck Surg mentioning

confidence: 99%

“…Several researchers have found decreased immunoglobulin (Ig) levels after adenotonsillectomy while others have not reported any significant changes. [1][2][3][4][5][6][7][8] Hence, a prospective case control study was planned to evaluate whether chronic adenotonsillitis had any effect on humoral immunity and whether adenotonsillectomy resulted in changes in humoral immunity as measured by serum immunogloblin levels.…”

Section: Introductionmentioning

confidence: 99%

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Effects of adenotonsillectomy on humoral immunity

Subramaniam

Pai

Mazumdar

2016

Int J Otorhinolaryngol Head Neck Surg

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Background: Adenotonsillectomy is one of the commonest surgical procedures performed by the otolaryngologists. The immunological effects of adenotonsillectomy have not been studied extensively. Some researchers have found decreased immunoglobulin levels after adenotonsillectomy while others have not reported any significant changes. The present study aimed to evaluate the changes in humoral immunity in patients undergoing adenotonsillectomy before and after surgery as measured by serum immunoglobulin levels.Methods: The study designed was a prospective observational case-control study conducted at Yenepoya Medical College Hospital, a tertiary referral hospital, Mangalore, Karnataka. A total of 25 patients in the age range 5-15years who underwent adenotonsillectomy for chronic adenotonsillitis and 25 age and sex matched controls participated in the study. Serum immunoglobulin G, A and M (IgG, IgA and IgM) levels were estimated 24 hours prior and 4 weeks after adenotonsillectomy. The statistical analysis used was non-parametric tests.Results: Serum levels of IgG, A and M were found to be significantly higher in patients with chronic adenotonsillitis. The levels of all the three immunoglobulins decreased to normal one month post-operatively.Conclusions: Removal of infected tissue and chronic antigenic stimulation resulted in restoration of serum immunoglobulin levels to normal. While chronic adenotonsillitis contributed to changes in humoral immunity as reflected by higher serum immunoglobulin levels, adenotonsillectomy enabled restoration of the immunoglobulin levels to normal.

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