Serum Immunoglobulin Levels in Children with Acute Lymphoblastic Leukaemia and Their Mothers and Sibs

Chandra, Ranjit Kumar

doi:10.1136/adc.47.254.618

Cited by 19 publications

(11 citation statements)

References 14 publications

(14 reference statements)

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“…Serum IgM levels in AML mothers were significantly higher (P<0*02) than those of their controls for the first blood sample, but not in the later ones. The results in ALL mothers did not confirm the raised IgM reported by Sutton et al (1969) and Chandra (1972), the raised IgG reported by Chandra (1972) and Hann et al (1975) or the raised IgA reported by Hann et al (1975). Evans (1973) similarly failed to find these differences.…”

Section: Discussioncontrasting

confidence: 54%

“…As it is impossible to distinguish between immunodeficiency of genetic origin and that resulting from the leukaemia or its treatment in the patients themselves, attempts have been made to uncover predisposing genetic immunodeficiency by studying the patients' relatives. Results of leucocyte counts, immunoglobulin estimations and lymphocyte transformation tests in the parents of children with leukaemia have shown no consistent differences from controls (Sutton et al, 1969;Chandra, 1972;Evans, 1973;Hann et al, 1975), but these measures are very crude indicators of immune function.…”

mentioning

confidence: 99%

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Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Till¹,

Rapson²,

Smith³

1979

Br J Cancer

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Summary.-Medical histories of themselves and their first-degree relatives were obtained from parents of 82 leukaemic children (54 acute lymphoblastic (ALL), 28 acute myeloblastic (AML)) and from control couples matched for age. The possibility of a primary familial immunological abnormality as an aetiological factor in childhood leukaemia was suggested by finding some infections significantly more frequently reported in parents than in controls, but more strongly supported by the finding of a significantly (P<0-02) increased prevalence of disorders associated with autoimmunity (but not of other conditions such as peptic ulceration, infective hepatitis, tuberculosis or malignancy) amongst members of ALL families compared to those of controls. Analogy with Down's syndrome and the strain of NZB mice, in which diminished T-cell function is associated with autoimmune disease and lymphoid neoplasia, is discussed.Varicella and herpes zoster occurred respectively in 2 ALL mothers during their pregnancies involving the patients and in none of the other 388 pregnancies here reported. This supports previous evidence that antenatal varicella infections may be of aetiological importance in some cases of ALL.

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Section: Discussioncontrasting

confidence: 54%

mentioning

confidence: 99%

Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Till¹,

Rapson²,

Smith³

1979

Br J Cancer

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“…In a different, but analogous, experimental situation such an activation of an endogenous, vertically transmitted, RNA tumour virus by a DNA virus has been demonstrated by Rhim and Huebner (1973). In man, some indirect evidence exists for the presence of such a vertically transmitted agent, in that raised IgM levels have been detected in neonatal sibs of children with leukaemia (Sutton, Bishun, and Soothill, 1969;Chandra, 1972).…”

Section: Discussionmentioning

confidence: 93%

Antibodies to Epstein-Barr and other viruses in children with acute lymphoblastic leukaemia

Sutton¹,

Marston²,

Pullen³

et al. 1974

Archives of Disease in Childhood

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“…This method of analysis is not particularly sensi tive. Studies of relatives of patients with acute leukaemia have revealed statistical differences in comparison with controls [Sutton et al, 1969;Chandra, 1972] with mothers having elevated IgM concentra tions and siblings having elevated cord blood IgM and later in life lower than ex pected values for IgG or IgA.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulins in Familial Hodgkin’s Disease and Immunodeficiency in Newfoundland

Ls¹,

Bryant²,

Buehler³

et al. 1980

Int Arch Allergy Immunol

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A familial aggregate of 7 cases of Hodgkin’s disease, 3 of common variable immunodeficiency, 8 of other lymphoreticular malignancies, and 4 of embryonic tumours is being studied in a multidiscipline fashion to search for clues to aetiology. Part of the investigation was to examine immunoglobulin concentrations in the whole population, both in family members and in other members of the same communities. Analysis of the data on some 1,200 people revealed the expected changes with age in IgG, IgA and IgM. A striking age-related pattern for IgD with a peak in puberty and young adulthood was noted. The expected sex differences were also seen which were marked for IgM and mild for IgG. The immunoglobulin concentrations in families in which there had been a case of malignancy or immunodeficiency showed two deviations from values derived from controls: (i) relatives of the common variable immunodeficiency patients showed an elevated mean IgM, and (ii) relatives of the Hodgkin’s disease patients and of the lymphosarcoma patients showed mean IgD concentrations that were 20 times as high as that of controls from outside the study population and were the highest of all the groups within it. However, when compared with the controls from elsewhere in the province, the mean IgD values in all subgroups of the study population were significantly elevated including in a genetically separate group not descended from an important founding couple. It is concluded that factors causing elevated IgD in this high lymphoma incidence population are likely to be predominantly determined by environment rather than by genetic factors. We postulate that the increase may be partly due to the low socio-economic status of the population, but the reason why the highest values are found in the lymphoma families is not immediately clear.

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Serum Immunoglobulin Levels in Children with Acute Lymphoblastic Leukaemia and Their Mothers and Sibs

Cited by 19 publications

References 14 publications

Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Family studies in acute leukaemia in childhood: a possible association with autoimmune disease

Antibodies to Epstein-Barr and other viruses in children with acute lymphoblastic leukaemia

Immunoglobulins in Familial Hodgkin’s Disease and Immunodeficiency in Newfoundland

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