Serum immunoglobulin and beta 1C-beta 1A globulin concentrations in juvenile rheumatoid arthritis.

Serological abnormalities in juvenile chronic arthritis: a review of 46 cases.

“…The serum complement level in patients with JCA ranged from low to high (Bluestone et al, 1970;Bianco et al, 1971;Goel et al, 1974;Hoyeraal and Mellbye, 1974a). In this study the serum C3 level was significantly higher in patients than in controls, but the difference between active and inactive groups, between males and females, and between different subgroups was not significant.…”

Intraarticular activation of the complement system in patients with juvenile rheumatoid arthritis

“…CH50 also correlated inversely with serum iron and C3 activity directly with joint index. However C3 protein did not correlate significantly with BSI or joint index; a previous study also found no association of disease activity and C3 protein levels (46). IgA, IgM, and IgG correlated with BSI, and IgA also correlated with serum CH50 and C9 and synovial fluid total protein and C9.…”

Hypogammaglobulinemic Patient with Polyarthritis Mimicking Rheumatoid Arthritis Finally Diagnosed as Septic Arthritis Caused by Mycoplasma hominis

“…Chronic arthritis in such patients is usually without erosions and responds well to gamma globulin replacement therapy, which is distinct from classic RA (2,9) and may be classified as a reactive arthritis (2). Furthermore, several reports have described arthritis due to autoimmune disorders, such as RA (1-3), JIA (4,5), and spondyloarthritis (6) associated with hypogammaglobulinemia, and only T cells can cause synovitis and arthritis (1, 3). Gold, sulfasalazine, prednisolone, methotrexate, and non-steroidal anti-inflammatory drugs (NSAIDs) are effective in these cases.…”

“…Autoimmune disorders associated with hypogammaglobulinemia have also been reported, such as rheumatoid arthritis (RA) (1-3), juvenile idiopathic arthritis (JIA) (4,5), ankylosing spondylitis (6), and systemic lupus erythematosus (SLE) (7). The prevalence of arthritis was reported to be 10-30% in patients with hypogammaglobulinemia (8), and some patients were reported to require disease-modifying antirheumatic drugs (2,3).…”