Serum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer
David Digomann,
Max Heiduk,
Charlotte Reiche
et al.
Abstract:Pancreatic ductal adenocarcinoma (PDAC) responds poorly to systemic treatment, including new immunotherapeutic approaches. Biomarkers are urgently needed for early disease detection, patient stratification for treatment, and response prediction. The role of soluble CD40 (sCD40) is unknown in PDAC. In this study, we performed a quantitative multiplex analysis of 17 immune checkpoint proteins in serum samples from patients with various stages of PDAC in a discovery study (n = 107) and analyzed sCD40 by ELISA in … Show more
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