Serum IL‐6 and IL‐1‐ra with sequential organ failure assessment scores in septic patients receiving high‐volume haemofiltration and continuous venovenous haemofiltration

Ghani, Rohana Abdul; Zainudin, Suehazlyn; Ctkong, Norella; Rahman, A. F. A.; Wafa, S. R.; Mohamad, M.S.F.; Manaf, Mohd Rizal Abdul; Ismail, Rahimah

doi:10.1111/j.1440-1797.2006.00600.x

Cited by 84 publications

(78 citation statements)

References 20 publications

(30 reference statements)

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“…20,21 IL-10, an anti-inflammatory factor secreted by Th2 cells, can inhibit many chemokines like IL-8 that participate in inflammation and has a certain immuneregulation effect. The present study found that the serum IL-8 and IL-6 levels dropped after IHVHF therapy, while the serum IL-10 level slightly increased.…”

Section: Discussionmentioning

confidence: 99%

Intermittent high-volume hemofiltration promotes remission in steroid-resistant idiopathic nephrotic syndrome

et al. 2015

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Inflammation is a key part in the etiology and progression of idiopathic nephrotic syndrome (INS), we hypothesize that removing pro-inflammatory cytokines with intermittent high-volume hemofiltration (IHVHF) could improve the outcome in INS patients. The purpose of the current study is to examine whether IHVHF promotes remission in steroid-resistant INS. Fifty-one steroid-resistant INS patients were followed up on an open-label basis with prospective evaluations. Thirty-five patients received mycophenolate mofetil (SRD group) and 16 patients received drugs and IHVHF due to volume overload despite of diuretics (SRDF group). The rate of complete remission (CR) was analyzed. We also recruited 30 healthy individuals and 36 steroid-sensitive (SS) INS patients as controls to investigate the correlation of interleukin (IL)-8, IL-10, IL-6 and IL-17 with INS activity. Compared with the patients in the SRD group, the 6-month CR rate was higher (44% vs. 9%, p50.001) and time to first CR was significantly shorter (7.3 ± 3.6 vs. 11.1 ± 5.3 months, p ¼ 0.02) in the SRDF group. Serum IL-8 was highest in the SRDF group and reduced by IHVHF clearance. Serum IL-8 was lower during remission than at onset or recurrence of INS, whereas no significant difference was seen in the other cytokines. Receiver operating characteristic curve analysis demonstrated that serum IL-8 predicted steroid sensitivity with moderate accuracy (area under the curve ¼ 0.79, 95% CI: 0.69-0.87). IHVHF promotes remission in patients with steroid-resistant INS and it may be partly due to serum IL-8 clearance.

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Section: Discussionmentioning

confidence: 99%

Intermittent high-volume hemofiltration promotes remission in steroid-resistant idiopathic nephrotic syndrome

et al. 2015

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“…An example of this can be found in IL-6. This cytokine is induced by proinflammatory stimuli and plasma IL-6 levels are often used as a marker of systemic inflammation [20][21][22][23]. While IL-6 is known to stimulate the hepatic acute phase response, it also results in other, decidedly anti-inflammatory effects including the induction of an adrenal glucocorticoid response [24,25].…”

Section: Cytokines and Chemokinesmentioning

confidence: 99%

Immunoparalysis and Adverse Outcomes from Critical Illness

Frazier

Hall

2008

Pediatric Clinics of North America

125

106

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“…Large quantities of IL-6 have been found in human atherosclerotic plaques, [23] and several studies revealed a direct link between IL-6 levels and CAD. [24] In our patients, there was a trend toward reduced plasma IL-6 levels after HDF, but the differences were not significant.…”

Section: Discussionmentioning

confidence: 86%