Serum IL-6, albumin and comorbidities are closely correlated with symptoms of depression in patients on maintenance haemodialysis

Hung, Kuo-Chin; Wu, Chia-Chao; Chen, Hsiao-Shuang; Ma, Wen-Ya; Tseng, Chin-Feng; Yang, L.-K.; Hsieh, Hsiang-Li; Lu, Kuo‐Cheng

doi:10.1093/ndt/gfq411

Cited by 68 publications

(69 citation statements)

References 35 publications

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“…Those with DS had higher interleukin-6 and lower albumin levels. 28 No association between hs-CRP and serum albumin level was observed in the present cohort. Cilan et al reported higher concentrations of pro-inflammatory cytokines in an HD population compared with a control group; however, no significant difference between patients with or without DS was demonstrated.…”

contrasting

confidence: 61%

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Barros

Costa

Mottin

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To prospectively evaluate depressive symptoms, nutritional status, and quality of life (QoL) and search for possible associations in patients with end-stage renal disease undergoing hemodialysis. Methods: A cohort study of 104 adult patients with end-stage renal disease undergoing hemodialysis was conducted. Anthropometric, clinical, and biochemical variables were evaluated after a midweek hemodialysis session. The participants' body composition was assessed by direct segmental multifrequency bioimpedance analysis. The WHOQOL-Bref questionnaire was used to evaluate QoL. Participants were separated into two groups -depressive symptoms and no depressive symptoms -at inclusion and evaluated annually for 2 years thereafter using the Beck Depression Inventory. Survival analysis used the Kaplan-Meier method and Cox regression analysis for the goodness of fit of associated factors. All-cause mortality was the outcome of interest. Results: Participants' mean age was 55.3615.6 years, 60% were male, and the median time on hemodialysis was 17.5 (8.0-36.8) months. Thirty-two patients had depressive symptoms and a significantly lower QoL compared with the 72 patients in the no depressive symptoms group. The fitted outcome model showed that lean body mass had a protective effect against all-cause mortality (hazard ratio [HR] = 0.89; 95%CI 0.80-0.99; p = 0.038). Conclusion: Depressive symptoms were highly prevalent in the cohort, and correlated with the physical and psychological components of the QoL life questionnaire, as well as with C-reactive protein and phosphorus levels. Lean body mass was protective for the assessed outcome.

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contrasting

confidence: 61%

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Barros

Costa

Mottin

et al. 2016

Rev. Bras. Psiquiatr.

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“…Similar results to what we found in this study have recently been reported by Hung et al (2011), who explored the relationship between depression and demographic, socio-economic and clinical variables in CKD patients [12]. In another study, Wuerth et al (2003) screened chronic peritoneal dialysis (PD) patients from July 1997 to October 2002, using the Beck Depression Inventory questionnaire.…”

Section: Discussionsupporting

confidence: 89%

Association between Chronic Kidney Disease and Depression

Bhatti¹,

Ali²,

Satti³

2014

OJNeph

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Background: Depression is relatively prevalent in chronic kidney disease (CKD) patients. Knowing the frequency of depression in these patients, the association with variables such as stage of disease, education, and income status may be helpful in devising strategies for better management. Methods: We examined 315 patients diagnosed with CKD presented in the outpatient and emergency department of medicine at Capital Hospital, Islamabad, Pakistan. Depression was diagnosed according to the Hamilton Depression Rating Scale of depressive episode. Results: In the dialysis group, 83.8% were depression positive, while in the pre-dialysis group only 61.3% of patients were given the same diagnosis (P < 0.05). A significant association was moreover found between depression and education status (P < 0.05), but not for income status. Conclusions: Considering the high incidence of depression in CKD patients, screenings should be routinely performed in order to identify and treat depression in its early stages for these patients.

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“…A recent study showed strong associations between depression, inflammation, and serum albumin in maintenance dialysis patients (75). It is recommended that patients with ESRD be screened at the initiation of dialysis therapy, within 3-6 months after therapy initiation, and then yearly using depression screening self-report questionnaires, such as the Beck Depression Inventory.…”

Section: Summary and Recommendationsmentioning

confidence: 99%

A Patient with CKD and Poor Nutritional Status

İkizler

2013

Clinical Journal of the American Society of Nephrology

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SummaryProtein energy wasting is common in patients with CKD and ESRD and is associated with adverse clinical outcomes, such as increased rates of hospitalization and death, in these patients. A multitude of factors can affect the nutritional and metabolic status of patients with CKD, including decreased dietary nutrient intake, catabolic effects of renal replacement therapy, systemic inflammation, metabolic and hormonal derangements, and comorbid conditions (such as diabetes and depression). Unique aspects of CKD also confound reliable assessment of nutritional status, further complicating management of this comorbid condition. In patients in whom preventive measures and oral dietary intake from regular meals cannot help them maintain adequate nutritional status, nutritional supplementation, administered orally, enterally, or parenterally, is effective in replenishing protein and energy stores. The advantages of oral nutritional supplements include proven efficacy, safety, and compliance. Anabolic steroids and exercise, with nutritional supplementation or alone, improve protein stores and represent potential additional approaches for the treatment of PEW. There are several emerging novel therapies, such as appetite stimulants, anti-inflammatory interventions, and anabolic agents.

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Serum IL-6, albumin and comorbidities are closely correlated with symptoms of depression in patients on maintenance haemodialysis

Cited by 68 publications

References 35 publications

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Association between Chronic Kidney Disease and Depression

A Patient with CKD and Poor Nutritional Status

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