Serum IL-17 levels in patients with allergic rhinitis

Ciprandi, Giorgio; Fenoglio, Daniela; Amici, Mara De; Quaglini, Silvana; Negrini, Simone; Filaci, Gilberto

doi:10.1016/j.jaci.2008.06.005

Cited by 57 publications

(61 citation statements)

References 12 publications

(29 reference statements)

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“…LF released by activated neutrophils may mediate numerous compensatory effects to inhibit allergic infl ammations, decreasing mast cell degranulation, tryptase activity, eosinophils' migration, and promoting the Th1-type immune responses (ELROD et al, 1997;HE et al 2003;DE LA ROSA et al, 2008;BOURNAZOU et al, 2010). Our other fi nding, that IL-17 was more frequently detectable and its levels were higher (although not signifi cantly) both in the serum and breast milk of allergic mothers, supports the previous observation that some patients with pollen-induced allergic rhinitis may have high serum IL-17 levels outside of the pollen season (CIPRANDI et al, 2008). However, in our study, only those infants became allergic, whose mothers had a very high LF level (306 μg mg -1 proteins) or simultaneously elevated LF or IL-17 concentrations in the breast milk on the 5 th day after delivery.…”

Section: Resultssupporting

confidence: 87%

A Possible Role of Elevated Breast Milk Lactoferrin and the Cytokine IL-17 Levels in Predicting Early Allergy in Infants: A Pilot Study

et al. 2016

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In this study, we examined the relationship between levels of lactoferrin (LF) and IL-17 in human serum and breast milk and the development of allergy in children. LF and IL-17 levels were determined by ELISA in healthy (n=19) and allergic mothers (n=21) on the 5 th day after delivery. Two years later, information on breastfeeding and allergic outcomes was collected by questionnaires from parents of both groups and district child care nurses. Signifi cantly higher concentrations of LF were found in the breast milk of allergic mothers compared to the healthy controls. At 2 years of age, only those three infants became allergic from the atopic group in whose starting breast milk samples a very high LF level (306 μg mg -1 protein) or simultaneously elevated concentrations of LF and IL-17 were measured. These fi ndings indicate that the very early measurement of LF and IL-17 levels in the breast milk of allergic mothers may help to predict the allergy development in their infants.

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Section: Resultssupporting

confidence: 87%

A Possible Role of Elevated Breast Milk Lactoferrin and the Cytokine IL-17 Levels in Predicting Early Allergy in Infants: A Pilot Study

et al. 2016

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“…A possible explanation might be that trees allergy in Ligurian patients is characterized by a relevantly increased prevalence and severity of symptoms (24). In addition, it has been very recently reported that patients with severe trees allergy also outside the pollen season have high IL-17 serum levels in comparison with patients sensitized to other pollens that have lower or undetectable IL-17 values (25). Moreover, another recent study pointed out that only mite allergy constitutes a very relevant risk factor for asthma development in patients with allergic rhinitis (26).…”

Section: Discussionmentioning

confidence: 99%

Impact of allergic rhinitis on asthma: effects on bronchial hyperreactivity

Cirillo¹,

Pistorio

Tosca

et al. 2009

Allergy

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Background: Remarkable relationship exists between upper and lower airways. Bronchial hyperreactivity (BHR) is a paramount feature of asthma and may be considered a strong risk factor for the onset of asthma in patients with allergic rhinitis.Objective: This study is aimed at evaluating the presence of BHR in a large group of patients with moderate‐severe persistent allergic rhinitis alone, and at investigating possible risk factors related to severe BHR.Methods: Three hundred and forty‐two patients with moderate‐severe persistent allergic rhinitis were prospectively and consecutively evaluated. Clinical examination, skin prick test, spirometry and bronchial methacholine (MCH) test were performed in all patients.Results: Twenty‐two (6.4%) patients had severe BHR, 74 (21.6%) patients had mild BHR and 192 (56.2%) had borderline BHR; 54 (15.8%) patients had a negative MCH test. The logistic regression analysis evidenced that trees and house dust mites sensitization (ORAdj: 8.1), rhinitis duration > 5 years (ORAdj: 5.4) and FEV1 ≤ 86% of predicted (ORAdj: 4.0) were significantly associated with severe BHR. The discriminative ability of this model is appreciably satisfactory, being the AUC = 0.90.Conclusion: This study highlights the close link between upper and lower airways and the role of some risk factors, such as tree and mite sensitization, > 5‐year duration, and ≤ 86% FEV1 values, as risk factors for severe BHR in patients with moderate‐severe persistent allergic rhinitis alone. Therefore, BHR is frequently present in patients with chronic rhinitis and should be suspected in the presence of defined risk factors.

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“…More recently, it was shown that serum IL-17 levels were significantly related with clinical symptoms, drug use, and peripheral eosinophils in patients with pollen-induced AR evaluated during the pollen season (9). Thus, serum IL-17 might be considered a biomarker of severe allergy in AR patients (8)(9). In addition, two recent studies reported an association between Th17 responses and symptom/medication score during SLIT, both in adults and children (lO-11).…”

mentioning

confidence: 99%

Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

Ciprandi

Castellazzi

Fenoglio

et al. 2010

Int J Immunopathol Pharmacol

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Th17 is a subset of T helper lymphocytes and exerts pro-inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in the most severe patients with birch allergy studied both outside and during the pollen season. This study aims to compare the frequency of peripheral IL-17-producing T:cells in children with allergic rhinitis and in healthy controls. Ten children with allergic rhinitis and 5 healthy non-allergic subjects were evaluated. Th17 were evaluated by intracellular staining in ex-vivo T cell compartment. Ex-vivo PBMNC evaluation showed that allergic patients had higher frequencies of IL-17 producing T cells, both concerning CD4+ and CD8+ cells. In particular, there is a subset co-expressing IL-17 and IFN-y both for CD4+ and CD8+ cells. In conclusion, this preliminary study suggests a possible role of Th-17 cells in the response to allergens in children.

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Serum IL-17 levels in patients with allergic rhinitis

Cited by 57 publications

References 12 publications

A Possible Role of Elevated Breast Milk Lactoferrin and the Cytokine IL-17 Levels in Predicting Early Allergy in Infants: A Pilot Study

A Possible Role of Elevated Breast Milk Lactoferrin and the Cytokine IL-17 Levels in Predicting Early Allergy in Infants: A Pilot Study

Impact of allergic rhinitis on asthma: effects on bronchial hyperreactivity

Peripheral TH-17 Cells in Children with Allergic Rhinitis: Preliminary Report

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