Serum IgG2 levels predict long-term protection following pneumococcal vaccination in systemic lupus erythematosus (SLE)

The 13-Valent Pneumococcal Conjugate Vaccine Elicits Serological Response and Lasting Protection in Selected Patients With Primary Humoral Immunodeficiency

“…Indeed, we observed that patients with higher serum IgG2 concentrations at diagnosis were more likely to stay protected at one-year. These data substantiate a recent study in patients with systemic lupus, for whom higher IgG2 serum concentrations were associated with long-term protection 36 months after a prime-boost PCV13/PPSV23 vaccination ( 33 ). IgG2 are known to play a key-role during pneumococcal infections ( 34 , 35 ).…”

T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens

“…Pre- and post-immunization serum IgG concentrations for seven pneumococcal serotypes (4, 6B, 9V, 14, 18C, 19F, and 23F) were measured as described in ( 72 ). Purified recombinant mAbs were tested against each of the capPS of Pneumovax.…”

Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS project

“…The observed B cell defect preventing a strong immune response to BNT162b2 mRNA could not be ascribed to drug-induced immunosuppression. Such poor immune response to vaccine is probably related to SLE – as our group previously reported in the setting of anti-pneumococcal vaccination [ [20] , [21] , [22] ]. Because SLE entails a risk for severe COVID-19 [ 1 , 2 ] , SLE patients are obvious candidates for alternative vaccination strategies [ 23 ].…”

“…Among SLE patients, the absolute count of circulating anti-Spike specific B cells measured by flow cytometry increased overtime and appeared maximal 6 months after the first vaccine shot (5 [ [4] , [5] , [6] , [7] , [8] , [9] , [10] ].10–5/mL anti-S specific B cells at T0 vs 16 [6–29] at M6, p = 0.009). Consistent with the poor humoral response, the absolute count of anti-S specific B cells was significantly lower in SLE patients as compared to HV at M1 (5 [ [4] , [5] , [6] , [7] , [8] , [9] , [10] ].10–5/mL anti-S specific B cells in SLE vs 14 [ [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] ].10–5/mL in HV; p = 0.004), M3 (11 [ [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] ].10–5/mL vs 30 [18–53].10–5/mL, p = 0.008) and M6 (16 [6–29].10–5/mL vs 27 [25–82].10–5/mL, p = 0.02) ( Fig. 1 B).…”