Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis

Erwin, Elizabeth A.; James, Hayley R.; Gutekunst, Heather M.; Russo, John; Kelleher, Kelly J.; Platts-Mills, Thomas A.E.

doi:10.1016/j.anai.2010.03.018

Cited by 132 publications

(125 citation statements)

References 33 publications

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“…This is parallel with the sutdy of Cooper (2004) and Alcântara-Neves et al (2010) which proposed the idea that Trichuris trichiura infection may mediate allergy with inhalants. The data corroborate with prior investigations showing considerable increased serum IgE levels with children irrespective of age (Arbes et al, 2011) and type of allergy (Erwin et al, 2010;Levin, Le Souëf, & Motala, 2008). In contrast, Agbonlahor et al (2013) postulated a link between parasitic infestation type and high serum total IgE levels in his study in Nigeria.…”

Section: ≥10 Years Old (N=11)supporting

confidence: 81%

Determination of Geohelminthiasis and Its Association with Allergic Sensitization among Selected Children in Batangas, Philippines

Magbojos¹,

Chua²,

Alegria³

et al. 2016

GJHS

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Several studies have explored the cross-reactivity between geohelminthiasis and allergy which share the same immune response in humans by triggering the increase in serum IgE level. Yet, the role of soil-transmitted intestinal parasitism as a protective or contributing factor for allergy remains inconclusive. In this study, the association of geohelminthiasis with allergic sensitization was investigated in a cohort of 50 children aged 5 to 12 years old residing in the areas of Batangas, Philippines where parasitism is prevalent. Stool samples of the subjects were qualitatively examined for the presence of helminth infection through modified Kato-Katz technique. They were also assessed for allergic diseases using the modified International Study of Asthma and Allergies in Childhood Phase I questionnaire. Fecalysis results were correlated with their serum total IgE (tIgE) levels and screening test results for allergic sensitization to common aeroallergens and food allergens determined through ImmunoCAP ® system. Of the participants, 78% were under 10 years old while 22% were aged 10 years old and above. Mixed infection of Ascaris lumbricoides and Trichuris trichiura were found to be the most common (40%) followed by trichuriasis (34%) and ascariasis (26%). Atopic allergy to inhalants is prevalent in children under 10 years old (74.36%) whereas, some of them (5.13%) are fX2 positive which confirms the participants' allergy to seafood. It was revealed that the occurrence of geohelminthic infection and allergy may affect any child regardless of age and serum total IgE level does not considerably vary with age, geohelminthiasis and presence of allergy. Hence, geohelminthiasis does not play contributory nor inhibitory role in allergic sensitization as established by a 0.05 level of significance (p≤0.05).

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Section: ≥10 Years Old (N=11)supporting

confidence: 81%

Determination of Geohelminthiasis and Its Association with Allergic Sensitization among Selected Children in Batangas, Philippines

Magbojos¹,

Chua²,

Alegria³

et al. 2016

GJHS

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“…In this case, children (13.5%) presented a high specific IgE to CPP compared with adults (11.4%), whereas the prevalence of self-reported adverse reaction to fish and shellfish was higher in adults (12.4%) than in children (9%). This variation was also observed in others studies where researchers have used different methods to detect food sensitivity in patients, suggesting that the use of IgE measurements may be helpful and added value to the diagnosis of food sensitivity (Čelakovská, Ettlerová, Ettler, Vaněčková, & Bukač, 2015;Erwin et al, 2010;Lim et al, 2008;Perez-Gordo et al, 2013;Yang et al, 2010).…”

Section: Discussionmentioning

confidence: 77%

Evaluation of the IgE reactivity of common pandora parvalbumin in a Moroccan population and action of heating and enzymatic treatments

Mejrhit

Azdad

Aarab

2017

Food and Agricultural Immunology

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The aim of this study was to evaluate the immunoglobulin E (IgE) sensitivity to common pandora (Pagellus erythrinus) parvalbumin (CPP) in a Moroccan population from the Fez region, and then to study the effect of temperature and enzymatic digestion on the allergenicity of CPP. This work was conducted with a questionnaire completed by a sera-bank, obtained from 500 patients recruited from Fez hospitals. Their sera were analyzed for specific IgE against CPP. Evaluation of specific IgE showed that 11.8% of patients present higher values (>150 IU/ml). Further indirect ELISA and dot-blot results indicated that CPP showed a decrease in the binding of anti-IgE under heating with an average diminution of 41.9%, while pepsin hydrolysis reduced IgE recognition by 22.9%. These results demonstrate that this population was sensitive to CPP and the sensitivity could be reduced by heating and pepsin hydrolysis with an action higher with temperature than enzymatic digestion processing. ARTICLE HISTORY

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“…Compared to healthy controls, the bacterial load of the esophagus is increased in patients with EoE regardless of treatment and disease activity, with a relative abundance of gram-negative bacteria in active EoE (68,69). Recently, IgE sensitization to Candida albicans has been reported in pediatric and adult patients with EoE (14,70). Whether an esophageal colonization with Candida albicans and later sensitization is owing to EoE inflammation or corticosteroid therapy remains to be investigated.…”

Section: Epithelial Barrier and Innate Immune Responses In Eoementioning

confidence: 99%

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

Simon

Cianferoni

Spergel

et al. 2016

Allergy

200

130

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Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and immunoglobulin E (IgE) sensitization to food allergens in children as well as to aeroallergens and cross-reactive plant allergen components in adults. Patients with EoE respond well to elemental and empirical food elimination diets. Recent research has, however, indicated that the pathogenesis of EoE is distinct from IgE-mediated food allergy. In this review, we discuss the individual roles of epithelial barrier defects, dysregulated innate and adaptive immune responses, and of microbiota in the pathogenesis of EoE. Although food has been recognized as a trigger factor of EoE, the mechanism by which it initiates or facilitates eosinophilic inflammation appears to be largely independent of IgE and needs to be further investigated. Understanding the pathogenic role of food in EoE is a prerequisite for the development of specific diagnostic tools and targeted therapeutic procedures.Abbreviations ACD, allergic contact dermatitis; AD, atopic dermatitis; APT, atopy patch test; DHR, drug hypersensitivity reactions; EoE, eosinophilic esophagitis; FPIES, food protein-induced enterocolitis; GERD, gastroesophageal reflux disease; GI, gastrointestinal; IBD, inflammatory bowel disease; Ig, immunoglobulin; OAS, oral allergy syndrome; PPI-REE, proton pump inhibitor-responsive esophageal eosinophilia; SFED, six-food elimination diet; SPT, skin prick test; TCR, T-cell receptor; TNF, tumor necrosis factor.Allergy 71 (2016) 611-620

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Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis

Cited by 132 publications

References 33 publications

Determination of Geohelminthiasis and Its Association with Allergic Sensitization among Selected Children in Batangas, Philippines

Determination of Geohelminthiasis and Its Association with Allergic Sensitization among Selected Children in Batangas, Philippines

Evaluation of the IgE reactivity of common pandora parvalbumin in a Moroccan population and action of heating and enzymatic treatments

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

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