Serum IgE in Primary Glomerular Diseases and Its Clinical Significance

Abstract

Total serum IgE was measured in 119 cases of primary glomerular diseases and 33 normal healthy persons. Statistically significant higher levels were noted in minimal change disease (MCD; median: 630 U/ml), IgM nephropathy (IgMN; 618 U/ml), focal glomerulosclerosis (FGS; 373 U/ml) and membranous glomerulonephritis (MGN; 144 U/ml). A higher level of serum IgE was noted in association with more frequent relapse or steroid resistance in MCD and IgMN and in FGS with nephrotic syndrome. A small group of IgA nephropathy with nephrotic range proteinuria was also noted to have extraordinarily high serum IgE. These findings suggest that IgE may play an important role in the pathogenesis of MCD, IgMN, and FGS and may serve as a prognostic indicator in terms of steroid responsiveness in MCD and IgMN.

Increase of CD23-Positive Cells in Peripheral Blood from Patients with IgA Nephropathy and Non-lgA Proliferative Glomerulonephritis

“…Many investigators noted that serum IgE in patients with minimal change nephrotic syndrome, focal and segmental glomerulosclerosis and membranous glomerulonephritis was significantly elevated [31,32], while other reports al leged that there was no significant elevation of serum IgE in IgAN, PGN and membranoproliferative glomerulonephri tis [33,34], However, serum IgE levels in IgAN and PGN patients were significantly elevated in the present study. The reason for the discrepancies among these studies is not obvious.…”

Effect of Mizoribine on Serum IgE Concentration in Patients with IgA Nephropathy

“…Many diseases associated with high serum IgA levels are characterized by T-cell disorders [2]. Hypersensitivity has been implicated in the pathogenesis of certain kinds of glomerulonephritis including minimal-change nephrotic syndrome, and serum IgE concentrations are usually elevated in these patients [3]. Yano et al [4] reported an increase of CD23-positive cells in peripheral blood obtained from patients with IgA nephropathy.…”

Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide, population-based cohort study

“…In the 1950s through the 1970s, few anecdotal reports described patients who developed INS after allergic reactions to inhaled allergens, vaccinations, food, or insect stings (2)(3)(4)(5). Since 1970, several case-control studies revealed that elevated serum IgE and atopic diathesis were more common in children with INS than non-INS controls (9,(11)(12)(13)(14)(15)(16)(17). Recently, levels of T helper 2 (Th2)-associated cytokine such as interleukin (IL)-4 and IL-13 were found to be elevated in relapsing INS patients (18)(19)(20)(21).…”

“…Recently, levels of T helper 2 (Th2)-associated cytokine such as interleukin (IL)-4 and IL-13 were found to be elevated in relapsing INS patients (18)(19)(20)(21). Children with INS commonly have elevated serum levels of immunoglobulin E (IgE), which also plays a central role in allergic inflammation (11)(12)(13)(14)(15)(16). Although clinical and immunological studies have shown a possible link between allergic diseases and INS for 50 y, human epidemiologic study using a large cohort to investigate the relationship between these disorders are lacking (2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”