Serum IgE concentration in atopic dermatitis *1Relationship to severity of disease and presence of atopic respiratory disease

Johnson, Eloise E.; Irons, John S.; Patterson, Roy; Roberts, Mary

doi:10.1016/0091-6749(74)90037-2

Cited by 133 publications

(26 citation statements)

References 6 publications

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“…However, we found no clear relationship between serum total IgE and IL-18 levels, although total IgE levels may be associated with AD severity [11]. In addition, we found no relationship between serum IL-18 levels and SEB-speciWc IgE.…”

Section: Discussioncontrasting

confidence: 67%

Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitis

et al. 2011

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Atopic dermatitis (AD) is a chronic inflammatory disease of the skin for which there are no reliable biomarkers to assess clinical severity. Serum interleukin-18 (IL-18) levels may be associated with AD severity. To identify putative biomarkers associated with clinical severity in adult AD patients, we enrolled 121 adult AD patients (mean age 35.7 years) and 50 healthy controls (mean age 31.7 years). We compared these groups for blood eosinophils and serum levels of IL-18, thymus and activation-regulated chemokine (TARC), total IgE, and lactate dehydrogenase (LDH). We also determined S. aureus enterotoxin B (SEB) specific IgE levels and the SCORingAD (SCORAD) scores for AD patients. For AD patients, stepwise logistic regression was used to estimate odds ratios (OR) for each biomarker for the likelihood of having AD, and multiple linear regression was used to identify biomarkers associated with SCORAD scores. Compared with healthy controls, adult AD patients had higher levels of IL-18, TARC, total IgE, eosinophils, and LDH. TARC levels had the highest OR for AD occurrence, while the OR for IL-18 was insignificant. Also, IL-18 was not related to the presence of SEB-IgE. Notably, IL-18 levels were significantly associated with SCORAD scores, as were TARC, total IgE, and LDH levels. A panel of biomarkers (IL-18, TARC, total IgE, and LDH) may be more useful to accurately assess clinical severity in adult AD patients.

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Section: Discussioncontrasting

confidence: 67%

Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitis

et al. 2011

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“…IgE may contribute to the characteristic inflammation seen in the skin of patients with atopic dermatitis. 12 Many patients have elevated serum concentrations of total and foodspecific IgE. 12 Studies in mice demonstrated an antigenspecific IgE-mediated activation of basophils, mast cells, and eosinophils in the skin.…”

Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

“…12 Many patients have elevated serum concentrations of total and foodspecific IgE. 12 Studies in mice demonstrated an antigenspecific IgE-mediated activation of basophils, mast cells, and eosinophils in the skin. 13 In a study by Sampson patients with food hypersensitivity as demonstrated by double-blind placebo-controlled food challenge (DBPCFC) that frequently ingested the offending food allergens had higher rate of "spontaneous" basophil histamine release at baseline.…”

Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

An Update on Pediatric Atopic Dermatitis and Food Allergies

Nguyen

Leonard

Eichenfield

2015

The Journal of Pediatrics

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“…Approximately 80% of patients with AD show increased values of total IgE and/or specific IgE against food allergens as infants, and environmental allergens as children and adults [3, 7]. Allergic inflammation provoked by these allergens plays an important role in the pathogenesis of allergic AEDS [7], and a correlation between high IgE levels and the severity of symptoms has also been reported in AD patients [37, 38]. In the current study, the IgE level was high in AD patients, and significant differences were noted in the serum total and HDM-specific IgE levels at the time of primary school entry between children with and without later remission of skin eruptions, suggesting that the infantile IgE level serves as a prognostic index.…”

Section: Discussionmentioning

confidence: 99%

Atopic Dermatitis, Dry Skin and Serum IgE in Children in a Community in Japan

Wakamori

Katoh²,

Hirano³

et al. 2009

Int Arch Allergy Immunol

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Background: Long-term, prospective studies investigating the prevalence, serum IgE and the natural history of atopic dermatitis (AD) in a community are lacking. Methods: In a Japanese community, the skin of primary school children and junior high school students was examined and a questionnaire was given to their parents; their serum total IgE, and house dust mite (HDM)- and Japanese cedar pollen (JCP)-specific IgE levels were also assessed once a year for 9 years. Results: The median AD prevalence in all students (492 in 1998 and 380 in 2004) was 7.6% (6.1–10.4%). The prevalence and the area of skin eruptions of AD decreased with growth. Serum total and HDM-specific IgE levels were high in AD patients, and significant differences were noted for both levels between children with and without later remission of skin eruptions at the time of primary school entry. IgE level increases were noted in the following order: healthy skin < dry skin < AD. In children presenting only with dry skin without atopic disorders, such as AD, asthma and allergic rhinitis, levels of total HDM- and JCP-specific IgE were significantly higher than in children with healthy skin. Conclusions: The infantile IgE level serves as a prognostic index, and sensitization to inhalant allergens may be easily established in individuals with clinically dry skin, even when AD is not present, and this may lead to the development of atopic disorders.

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Serum IgE concentration in atopic dermatitis *1Relationship to severity of disease and presence of atopic respiratory disease

Cited by 133 publications

References 6 publications

Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitis

Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitis

An Update on Pediatric Atopic Dermatitis and Food Allergies

Atopic Dermatitis, Dry Skin and Serum IgE in Children in a Community in Japan

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