Serum IgA and IgG Gliadin Antibodies and Small Intestinal Mucosal Damage in Children

Lindberg, Tor; La, Nilsson; Borulf, S.; Cavell, B; Sp, Fällström; Jansson, Ulf; Stenhammar, Lars; Stintzing, G

doi:10.1097/00005176-198512000-00011

Cited by 28 publications

(21 citation statements)

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“…In children with coeliac disease, gluten challenge is known to signi®cantly increase IgG and IgA levels to gluten, whereas gluten elimination decreases these (Scott et al, 1985;Lindberg et al, 1985;Wauters et al, 1991). In healthy subjects a chronic increase of dietary antigens does not affect food antibody concentrations even if single large loads of dietary antigens may lead to formation of food antibodies as a physiological response (Gallagher et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Milk hypersensitivity in young adults

et al. 1999

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Objective: To estimate the prevalence of milk hypersensitivity in Finnish adults. Design: Cross-sectional study. Subjects: Two hundred men and 206 women aged 27 y randomly recruited from the population register in southwestern Finland. Interventions: The subjects were interviewed about their dairy product consumption, abdominal discomfort after dairy product intake and lactose intolerance. From serum samples, serum reactivity to milk protein and milk-speci®c IgG 1 , IgG 2 , IgG 3 and IgA were measured. Results: About 20% of the subjects reported abdominal discomfort after dairy product intake, whereas only 6.4% had been diagnosed to have lactose intolerance. The amount of milk consumed correlated well with the serum assay results in subjects reporting abdominal discomfort but not in subjects who were free from these symptoms. Among subjects with no record of dairy product restriction or lactose intolerance, those experiencing abdominal discomfort after dairy product intake had signi®cantly higher serum reactivity to milk protein than those without such discomfort. The concentrations of serum milk-speci®c antibodies did not differ between these two groups. The prevalence of milk hypersensitivity in this population was estimated to be 3 ± 6%. Conclusions: Milk hypersensitivity may be as common in adults as in infants. The measurement of serum reactivity to milk protein may prove useful in screening milk hypersensitivity in subjects who have not restricted their dairy product consumption.

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Section: Discussionmentioning

confidence: 99%

Milk hypersensitivity in young adults

et al. 1999

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“…Antigliadin (IgA and IgG) antibodies were assessed by a modified enzymelinked immunosorbent assay (DIG-ELISA) as described elsewhere (Kilander et al, 1983;Lindberg et al, 1985). Antiendomysial antibodies of the IgA type (EmA) were detected by the indirect immunofluorescence technique using monkey oesophagus as the substrate (Ascher et al, 1996).…”

Section: Histopathologymentioning

confidence: 99%

Adult coeliac patients do tolerate large amounts of oats

et al. 2003

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Objective: The aim of the present study was to investigate whether adult patients with coeliac disease in remission could include large amounts of oats in their daily gluten-free diet for an extended period of time without adverse effects. Design, subjects and methods: Twenty adult coeliac patients in remission included large amounts of uncontaminated rolled oats in their daily diet for a prolonged period. The examinations, performed four times during the study period, included small bowel endoscopy with biopsies, blood samples (nutritional status, serological analysis), height and body weight, gastrointestinal symptoms and dietary records. Gastrointestinal symptoms and diet were also investigated through unannounced telephone interviews once a month during the study period. Results: No adverse effects of a large intake of oats were seen in small bowel histology, serology nor in nutritional status in the 15 subjects who completed the whole study period. Two of the subjects dropped out because of gastrointestinal symptoms and three for non-medical reasons. The median intake of oats was 93 g=day and the compliance to the oat diet was found to be good. Examinations of the patients after drop-out did not show any deterioration in small bowel histology or nutritional status nor raised levels of antibodies. Conclusion: Results from this study indicate that adult patients with coeliac disease in remission can include large amounts of controlled wheat-free rolled oats for an extended period of time without adverse effects.

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“…In those patients with probable or proven CD, higher levels of AGA IgA of more than 70 Units/ml exhibit more severe mucosal damage in the small intestine (3). AGA IgA appeared to be a good indicator of the immune reaction in the small intestine triggered by gluten (2,6,7). The extent of elevated AGA IgA in combination with a clinical history may be valuable in discerning which patients should undergo upper endoscopy for biopsies.…”

Section: Characteristics N=16mentioning

confidence: 99%

Isolated positive anti-gliadin immunoglobin-A antibody in children with gastrointestinal symptoms

Karnsakul

Skitarelic

Gillespie

et al. 2012

Turk J Gastroenterol

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Amaç: Çölyak hastal›¤› taramas›nda, anti-gliadin immunglobulin G ve A antikorlar›n›n kullan›m›, doku transglutaminaz ve endomisyal antikorlar›n daha yüksek olan duyarl›l›k ve özgüllü¤ü nedeniyle giderek azalmaktad›r. Kan›tlanm›fl ve muhtemel çölyak hastal›¤› olgular›nda, yüksek anti-gliadin immunglobulin A de¤erleri daha ciddi mukozal hasarla iliflkilidir. Çal›flman›n amac›, anti-gliadin immunglob

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Serum IgA and IgG Gliadin Antibodies and Small Intestinal Mucosal Damage in Children

Cited by 28 publications

References 0 publications

Milk hypersensitivity in young adults

Milk hypersensitivity in young adults

Adult coeliac patients do tolerate large amounts of oats

Isolated positive anti-gliadin immunoglobin-A antibody in children with gastrointestinal symptoms

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