Serum hyaluronate level as a predictor of radiologic progression in early rheumatoid arthritis

Paimela, Leena; Heiskanen, Arja; Kurki, Pekka; Helve, T; Leirisalo‐Repo, Marjatta

doi:10.1002/art.1780340706

Cited by 72 publications

(32 citation statements)

References 25 publications

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“…8 Other studies found a lower rate of erosiveness than our study (67% v 37% 9 and 29% 10 ) in patients with a longer period of evolution-that is <12 9 or <24 10 months. There may be several reasons for these different results.…”

Section: Discussioncontrasting

confidence: 53%

Factors related to radiological damage in 61 Spaniards with early rheumatoid arthritis

Richi

2002

Annals of the Rheumatic Diseases

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Objective: To determine whether the presence of radiographic erosions at disease onset in patients with early rheumatoid arthritis (RA) is associated with clinical, serological, or genetic factors of poor outcome and whether patients with erosions only in the feet have a different pattern of presentation. Methods: Sixty one patients with early RA (<6 months of evolution) were studied. Clinical evaluation and serological, radiological, and genetic studies were performed at disease onset and after one year. Results: Forty one (67%) patients showed erosions in their hands or in their feet, or in both. Subjects with erosive RA had a higher number of swollen joints (SJN; 9 (SD 6) v 6 (3), p=0.008), and rheumatoid factor (RF) positivity was more common (80% v 50%, p<0.02) than those without erosions. Seven (17%) of the 41 patients in the group with erosions had erosions only in their feet. This group had a longer duration of morning stiffness (120 (60) v 72 (52) min, p<0.005), better patient's global assessment of general health (34 (22) v 57 (25), p< 0.05), and lower erythrocyte sedimentation rate (32 (22) v 60 (30) mm/1st h, p <0.05) than the rest of the subjects with erosions, and none of them was in remission after one year. Remission after one year was related to a lack of cortical damage at onset and RF negativity. Conclusions: Radiological damage at disease onset is associated with a worse clinical presentation and RF positivity, which are markers of poor outcome. There is a subgroup of patients, with erosions only in their feet, whose clinical presentation is less aggressive. To identify these cases of early erosive RA, radiographs of the feet should be obtained routinely. R heumatoid arthritis (RA) has a highly variable course and different prognosis in each person. It is important to identify risk factors which lead to a worse outcome. Therefore we studied the relation between the presence of early radiological erosions in small joints and those variables previously identified as risk factors.

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Section: Discussioncontrasting

confidence: 53%

Factors related to radiological damage in 61 Spaniards with early rheumatoid arthritis

Richi

2002

Annals of the Rheumatic Diseases

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“…In conclusion, levels of serum HA, which are thought to be a marker of synovial inflammation (21,22) and have been shown to correlate with ongoing joint damage in RA (23), also predict disease progression in established tibiofemoral OA, a disease in which systemic markers of inflammation are usually within the normal range. The only other serum measure that has been reported to be of prognostic significance in OA is insulin-like growth factor 1 (24).…”

Section: Discussionmentioning

confidence: 92%

Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee

Sharif

George

Shepstone

et al. 1995

Arthritis & Rheumatism

165

105

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Objective. To investigate the prognostic value of serum hyaluronic acid (HA) and keratan sulfate (KS) levels in relation to tibiofemoral osteoarthritis (OA) of the knee.Methods. Clinical and demographic data were collected on 94 patients. Radiographs were obtained at study entry and at 5-year followup. Disease progression was defined as 2 mm of joint space narrowing of any tibiofemoral compartment, and/or knee joint surgery during the study period. Serum HA and KS were measured and levels were correlated with entry data and disease progression.Results. At entry, HA levels were significantly related to disease duration (P = 0.036), minimum joint space (P = 0.049), and previous surgery (P = 0.001).After these variables were taken into account, patients whose disease had progressed were shown to have had significantly higher levels of HA at baseline compared with those whose disease had not progressed (P = 0.019). However, there were no significant differences in levels of serum KS between those with and those without disease progression, at entry (P = 0.779) or at subsequent visits.Conclusion. These results suggest that serum HA levels predict disease outcome in OA of the knee and confirm that a single measurement of the serum level of KS is not useful as a prognostic marker in OA.Osteoarthritis (OA) is the most common cause of pain and disability in the elderly (1). Between 2% Supported by the Arthritis and Rheumatism Council.

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“…Another parameter which also correlated with the increase of serum HYA levels was the Ritchie index, indicating that the serum HYA level provides a measure of synovitis mass [12]. Of clinical importance was the observation that high serum HYA levels early in the disease indicate a more aggressive course with progressive erosion [13].…”

Section: Serum Analysis In Rheumatic Diseasesmentioning

confidence: 99%

Hyaluronan in joint disease

Engström‐Laurent

1997

Journal of Internal Medicine

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Engström‐Laurent A (University of Umeå, Umeå, Sweden). Hyaluronan in joint disease (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 57–60. Hyaluronan is a major component of synovial fluid. It is synthesized in the joint and partly degraded in joint capsule and partly carried by lymph to lymph nodes and the general circulation. During various joint disorders, especially inflammatory ones, the amount of hyaluronan in the joint and its turnover rate are increased leading to pathologically high serum levels of the polysaccharide. These levels are a complex function of synovitis mass and the physical activity of the patient. Intra‐articular injection of hyaluronan has been used in the treatment of osteoarthritis. Although it results in a relief of pain, controlled clinical trials have not yet convincingly shown any beneficiary effects of the treatment.

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Serum hyaluronate level as a predictor of radiologic progression in early rheumatoid arthritis

Cited by 72 publications

References 25 publications

Factors related to radiological damage in 61 Spaniards with early rheumatoid arthritis

Factors related to radiological damage in 61 Spaniards with early rheumatoid arthritis

Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee

Hyaluronan in joint disease

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