Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis

Shu, Jianlong; Sun, Xinping; Li, Ji; Li, Fengzhen; Tang, Jie; Shi, Lianjie

doi:10.1007/s10067-020-05093-5

Cited by 11 publications

(20 citation statements)

References 27 publications

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“…The two vertical axes, vertical middle axis, hollow circles, and two ends of the dotted lines respectively represent 95% confidence interval, overall odd ratio, pooled odd ratios, and 95% confidence interval Fig. 3 Forest plot of 9 studies in HCY levels for AS patients versus controls, based on random effects model reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and anti-citrullinated protein antibody (ACPA) in RA [16]. Our study indicates no significant correlation between HCY levels and AS disease activity.…”

Section: Discussionmentioning

confidence: 99%

“…Out of a total of 15 relevant studies found, 9 original studies met our inclusion criteria and were selected for this meta-analysis. These 9 studies were published between 2005 and 2020 and included 778 AS patients and 522 controls [16,[34][35][36][37][38][39][40][41]. Of the 9 studies, 4 were conducted in Asia, 3 in Asia-Europe (Turkey), 1 in Europe, and 1 in South America.…”

Section: Publication Search and Study Characteristicsmentioning

confidence: 99%

“…Of the 9 studies, 4 were conducted in Asia, 3 in Asia-Europe (Turkey), 1 in Europe, and 1 in South America. As of the controls, 1 study included non-inflammatory low back pain [39], 1 included osteoarthritis or soft tissue rheumatism [41], and the other 7 included healthy controls [16,[34][35][36][37][38]40]. Our methodological quality assessment showed the NOS scores of included studies ranged from 7 to 8.…”

Section: Publication Search and Study Characteristicsmentioning

confidence: 99%

“…Homocysteine (HCY) is a sulfur-containing amino acid formed during the metabolism of methionine to cysteine [8]. HCY levels are elevated in many acquired disorders such as cardiovascular disease, cerebrovascular disease, dementia-type disorders, osteoporosis-associated fractures, chronic renal disease, autoimmune diseases, inflammatory diseases, deficiency of vitamins B6, B12, or folic acid, as well as during anti-folate drug therapy [9][10][11][12][13][14][15][16][17][18][19] Elevated HCY may trigger autoimmune reactions through binding and structurally modifying specific proteins, resulting in the formation of neoantigens that are potentially relevant either in the onset of specific autoimmune diseases or in the progression of the associated cardiovascular damage [20].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies reported high levels of serum/plasma HCY levels in AS patients [34][35][36][37][38]. In contrast, others claimed that HCY levels in AS patients were similar or lower compared with control patients [16,[39][40][41]. Therefore, in this meta-analysis, we aim to determine HCY levels in AS and investigate the correlation between HCY levels and disease activity and medical treatments.…”

Section: Introductionmentioning

confidence: 99%

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Association of homocysteine with ankylosing spondylitis: a systematic review and meta-analysis

Sai

et al. 2021

Adv Rheumatol

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Background Hyperhomocysteinemia is associated with autoimmune diseases such as ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). Current findings regarding plasma/serum homocysteine (HCY) levels in AS patients are inconsistent. This study aims to systematically evaluate the association between circulating HCY levels and AS. Methods Online electronic databases (PubMed, Web of Science, Embase, ScienceDirect, China National Knowledge Infrastructure (CNKI), and Wanfang data) were used to retrieve all relevant articles published up to May 7, 2020. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using the random-effect model, Stata16 software. Results Nine articles containing 778 AS patients and 522 controls were included in this meta-analysis. No significant differences in HCY levels were found between AS and control groups (pooled SMD = 0.46, 95% CI = − 0.30 to 1.23, P = 0.23). However, subgroup analysis suggested that HCY levels were significantly higher (P < 0.05) in the AS group treated with methotrexate (MTX) compared with the control group. In contrast, HCY levels were significantly (P < 0.05) lower in the AS group receiving anti-TNF-α treatment compared with the control group. No significant differences were detected between HCY levels and disease activity scores (Bath AS disease activity index, BASDAI), and methylenetetrahydrofolate reductase (MTHFR) C677T genotype. Conclusion This meta-analysis indicates that HCY levels are similar between AS and controls, and do not correlate with disease activity. However, different medical treatments cause fluctuations of circulating HCY levels in AS patients. Further and larger-scale studies are needed to confirm these findings. Trial registration This study was registered at international prospective register of systematic reviews (PROSPERO), registration number: CRD42020184426.

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Section: Discussionmentioning

confidence: 99%

Section: Publication Search and Study Characteristicsmentioning

confidence: 99%

Section: Publication Search and Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of homocysteine with ankylosing spondylitis: a systematic review and meta-analysis

Sai

et al. 2021

Adv Rheumatol

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Construction of an easy‐to‐use predictive model for ultrasound‐detected tophi to improve the detection of hidden tophi

Liu

Zhao

Zang

et al. 2023

Rheumatology & Autoimmunity

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BackgroundMusculoskeletal ultrasound is used in clinical practice to evaluate gout patients and is an effective imaging tool for the detection of tophi. The aim of this study was to analyze the factors associated with ultrasound‐detected tophi in gout patients and to construct a clinical model to predict its occurrence and improve the detection of hidden tophi.MethodsData of gout patients admitted to Beijing Jishuitan Hospital from January 2015 to December 2021 were collected. The complete and detailed information from gout cases with completed musculoskeletal ultrasound was included in the analysis. Univariate and multivariate analyses were used to identify independent factors associated with ultrasound‐detected tophi. A nomogram was used to visualize the clinical predictive models.ResultsAmong 517 gout patients, rheumatologists found that 67 patients (13.0%) had subcutaneous tophi by visual observation, while musculoskeletal ultrasound revealed that 123 patients (23.8%) had ultrasound‐detected tophi with odds ratio [OR] (95% confidence intervals [CIs]) = 2.20 (1.81–2.67). Disease duration, upper limb joint flare (ULJF), persistent joint pain (PJP), uric acid, and homocysteine levels were independently associated with ultrasound‐detected tophi, and they had ORs (95% CIs) of 1.092 (1.050–1.136), 3.732 (2.312–6.025), 1.864 (1.086–3.200), 1.003 (1.001–1.004), and 1.015 (1.000–1.030), respectively. After balancing the complexity and accuracy of the model, Model 2 (incorporating disease duration, ULJF, PJP, and uric acid) was chosen to create a nomogram to predict the occurrence of ultrasound‐detected tophi. The nomogram had good discrimination (consistency index [C‐index] = 0.774) and excellent calibration, demonstrated by calibration curves.ConclusionUsing easily available indicators, such as disease duration, the nature of the joint pain, and uric acid levels, we successfully developed an easy‐to‐use clinical model to improve the detection of hidden tophi.

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Homocysteine as a trigger and potential therapeutic target for autoimmune diseases

Wang

Zhao

et al. 2023

Autoimmunity Reviews

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Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis

Cited by 11 publications

References 27 publications

Association of homocysteine with ankylosing spondylitis: a systematic review and meta-analysis

Association of homocysteine with ankylosing spondylitis: a systematic review and meta-analysis

Construction of an easy‐to‐use predictive model for ultrasound‐detected tophi to improve the detection of hidden tophi

Homocysteine as a trigger and potential therapeutic target for autoimmune diseases

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