Serum homocysteine concentrations in Chinese children with autism

Tu, Wen‐Jun; Yin, Changhao; Guo, Yanqin; Li, Siou; Chen, Hui; Zhang, Yan; Feng, Yong-lu; Long, Bao-hua

doi:10.1515/cclm-2012-0196

Cited by 21 publications

(16 citation statements)

References 15 publications

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“…Elevated plasma levels of Hcy have been previously associated with several neuropsychiatric disorders, including schizophrenia (Kale et al, 2010), and bipolar disorder (Dittmann et al, 2008). Our results are in line with previously reported data that suggested significantly higher levels of serum Hcy in children diagnosed with autism, compared to non‐autistic children (Ali et al, 2011; Tu et al, 2013 Tu et al, 2013). It has been suggested that elevated serum levels of Hcy can be due to both nutritional and genetic factors (Dhonukshe‐Rutten et al, 2009; Wijsman et al, 2011).…”

Section: Discussionsupporting

confidence: 94%

Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders

Han

Dai

et al. 2015

Intl J of Devlp Neuroscience

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Autism spectrum disorder (ASD) is a neurological disorder that presents a spectrum of qualitative impairments in social interaction, communication, as well as restricted and stereotyped behavioral patterns, interests, and activities. Several studies have suggested that the etiology of ASD can be partly explained by oxidative stress. However, the implications of abnormal transsulfuration metabolism and oxidative stress, and their relation with ASD are still unclear. The purpose of this study was to evaluate several transsulfuration pathway metabolites in Chinese participants diagnosed with ASD, to better understand their role in the etiology of this disorder. Fifty children (39 male, 11 female) diagnosed with ASD and 50 age- and gender-matched non-ASD children (i.e., control group) were included in this study. This prospective blinded study was undertaken to assess transsulfuration and oxidative metabolites, including levels of homocysteine (Hcy), cysteine (Cys), total glutathione (tGSH), reduced glutathione (GSH), oxidized glutathione (GSSG), and glutathione ratio (GSH/GSSG). The clinical severity of ASD was evaluated with the Childhood Autism Rating Scale (CARS), and the autistic children's present behavior was measured by the Autism Behavior Checklist (ABC). The results indicated that Hcy and GSSG levels were significantly higher in children diagnosed with ASD, Cys, tGSH and GSH levels as well as the GSH/GSSG ratio showed remarkably lower values in ASD children compared to control subjects. Hcy levels correlated significantly with increasing CARS scores and GSSG levels in children with ASD. Our results suggest that an abnormal transsulfuration metabolism and reduced antioxidant capacity (i.e., hyperhomocysteinemia and increased oxidative stress), and Hcy level appears to have a potentially negative impact on clinical severity of autistic disorder.

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Section: Discussionsupporting

confidence: 94%

Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders

Han

Dai

et al. 2015

Intl J of Devlp Neuroscience

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“…The need to understand the causes of ASD and the underlying pathophysiology has become more acute since the number of diagnosed cases has increased markedly in recent years [14]. In our study, we assessed serum BDNF levels in children with ASD and its correlation with the severity of autism.…”

Section: Discussionmentioning

confidence: 99%

Increased serum levels of brain-derived neurotrophic factor in autism spectrum disorder

Wang

Chen²,

Yu³

et al. 2015

NeuroReport

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The aim of this study was to investigate the potential role of brain-derived neurotrophic factor (BDNF) in children with autism spectrum disorders (ASD) by measuring serum circulating levels of BDNF as well as calcium and comparing them with age-matched and sex-matched normal controls. The study included 75 drug-naive ASD children and 75 age-sex-matched healthy children. The concentration of serum BDNF was determined using the enzyme-linked immunosorbent assay method at baseline. Clinical information was collected. The severity of ASD was assessed at admission using the Childhood Autism Rating Scale total score. The results indicated that the mean serum BDNF levels were significantly (P<0.0001) higher in children with ASD compared with the control cases (17.59±5.55 vs. 11.21±2.79 ng/ml; t=8.902). On the basis of the receiver operating characteristic curve, the optimal cutoff value of serum BDNF levels as an indicator for auxiliary diagnosis of autism was projected to be 12.65 ng/ml, which yielded a sensitivity of 80.8% and a specificity of 70.2%; the area under the curve was 0.840 [95% confidence interval (CI), 0.777-0.904]. In univariate logistic regression analysis, with an unadjusted odds ratio of 9.42 (95% CI, 4.33-25.95; P<0.0001), BDNF of 12.65 ng/ml or more had an association with a diagnosis of ASD. After adjusting for possible covariates, BDNF of 12.65 ng/ml or more is still an independent indicator of ASD, with an adjusted odds ratio of 7.33 (95% CI, 2.98-16.55; P<0.0001). Serum BDNF levels may be associated independently with the severity of ASD, and higher BDNF levels could be considered an independent diagnostic marker of ASD.

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“…It is directly toxic to neurons and blood vessels and can induce DNA strand breakage, oxidative stress, and apoptosis [11]. The role of HCY as a potential and predictive biomarker in Alzheimer's disease [12], cognitive impairment [13], and autism [14] has been well recognized. Studies in other countries report the same dose-response relationship between homocysteine and vascular disease [15,16].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels

et al. 2015

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Inflammatory processes have fundamental roles in depression. The primary purpose of this study was to assess the serum levels of high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) at admission to the presence of poststroke depression (PSD). From December 2012 to December 2013, first-ever acute ischemic stroke patients who were admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Serum levels of Hs-CRP and HCY were tested at admission. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6 months after stroke. Ninety-five patients (42.0%) showed depression (major + minor) at 6 months after admission, and in 69 patients (30.5%), this depression was classified as major. In the 69 patients with major depression, our results showed significantly higher Hs-CRP and HCY levels at admission than patients without major depression. After adjusting all other possible covariates, Hs-CRP and HCY still were independent predicators of PSD with adjusted OR of 1.332 (95% CI, 1.230-1.452; P < 0.001) and 1.138 (95% CI, 1.072-1.274; P < 0.001), respectively. The area under the receiver operating characteristic curve values of Hs-CRP and HCY were 0.765 (95% CI, 0.701-0.9825) and 0.684 (95% CI, 0.610-0.757) for PSD, respectively. The prognostic accuracy of combined model (HCY and Hs-CRP) was higher compared to those biomarkers alone and other markers. Elevated serum levels of Hs-CRP and HCY at admission were found to be associated with depression 6 months after stroke, suggesting that these alterations might participate in the pathophysiology of depression symptoms in stroke patients.

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Serum homocysteine concentrations in Chinese children with autism

Cited by 21 publications

References 15 publications

Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders

Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders

Increased serum levels of brain-derived neurotrophic factor in autism spectrum disorder

Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels

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